Next generation risk assessment of biocides (PHMG-p and CMIT/MIT)-induced pulmonary fibrosis using adverse outcome pathway-based transcriptome analysis

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 476, P. 134986 - 134986

Published: June 20, 2024

Next-generation risk assessment (NGRA) has emerged as a promising alternative to non-animal studies owing the increasing demand for of inhaled toxicants. In this study, NGRA was used assess inhalation risks two biocides commonly humidifier disinfectants: polyhexamethylene guanidine phosphate (PHMG-p) and chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT). Human bronchial epithelial cell transcriptomic data were processed based on adverse outcome pathways establish transcriptome-based points departure (tPODs) each biocide. tPOD values 0.00500–0.0510 μg/cm2 0.0342–0.0544 PHMG-p CMIT/MIT, respectively. tPODs may provide predictive power comparable that traditional animal-based PODs (aPODs). The tPOD-based determined both CMIT/MIT present high risk. Moreover, identified posed higher than children more susceptible population compared adults. This finding is consistent with observations from actual exposure events. Our findings suggest transcriptomics offers reliable approach specific disinfectant biocides, while acknowledging limitations current models in vitro systems, particularly regarding uncertainties pharmacokinetics (PK) pharmacodynamics (PD). study utilizes Risk Assessment evaluate common disinfectants. Transcriptomic human cells employed (tPODs), revealing posing CMIT/MIT. Children population, real-world research identifies these hazardous due their potential respiratory health impacts provides using transcriptomics, contributing addressing environmental concerns over biocide exposure.

Language: Английский

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Emission characteristics, environmental impact, and occupational health risks assessment of volatile organic compounds (VOCs) in the hairdressing sector

Atmospheric Pollution Research, Journal Year: 2025, Volume and Issue: unknown, P. 102471 - 102471

Published: Feb. 1, 2025

Language: Английский

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Exposure to polluted environments rich in inhalable aerosols: A study on transport and deposition patterns of aerosol particles in the human respiratory tract

Journal of Aerosol Science, Journal Year: 2025, Volume and Issue: unknown, P. 106581 - 106581

Published: March 1, 2025

Language: Английский

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Insights Into Formation and Aging of Secondary Organic Aerosol From Oxidation Flow Reactors: A Review

Current Pollution Reports, Journal Year: 2024, Volume and Issue: 10(3), P. 387 - 400

Published: April 16, 2024

Language: Английский

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Influence of ozone pollution on the mixing state and formation of oxygenated organics containing single particles

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 926, P. 171880 - 171880

Published: March 26, 2024

Language: Английский

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Analysis of gaseous emission and particle number size distributions in metal casting processes with binder jetting moulds

Building and Environment, Journal Year: 2024, Volume and Issue: 252, P. 111297 - 111297

Published: Feb. 12, 2024

Language: Английский

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Characteristics of secondary aerosol formation during shortened multiday reaction experiments in a smog chamber: Effects of relative humidity and ammonia

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 954, P. 176740 - 176740

Published: Oct. 8, 2024

Shortened multiday reaction experiments were conducted using the KIST chamber for atmospheric processes simulation (K-CAPS) to characterize effects of ammonia (NH

Language: Английский

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