Neurotoxicity Following Exposure to Micro and Nanoplastics

OBM Neurobiology, Journal Year: 2025, Volume and Issue: 09(01), P. 1 - 20

Published: March 16, 2025

The pervasive presence and enduring existence of micro nanoplastics in the environment render their exposure to humans aquatic creatures unavoidable. Research indicates these tiny plastic particles can be taken by beings mammals. Once within body, have capability infiltrate brain, although level penetration subsequent neurotoxic effects are not fully explored. Previous studies indicate that metal (oxide) nanoparticles enter brain induce effects. Given chemical resemblances between inert nanoparticles, this review aims summarize existing on implications across various species vitro settings. current evidence, incomplete, suggests may lead oxidative stress, potentially causing cell damage raising risk developing neurological disorders. Moreover, such could inhibit acetylcholinesterase activity alter neurotransmitter levels, contributing observed behavioral changes. There is a notable lack systematic comparison regarding stemming from different particle types, shapes, sizes at concentrations durations exposure. Understanding aspects essential for further evaluating danger associated with nanoplastics.

Language: Английский

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Interactions between intestinal microbiota and metabolites in zebrafish larvae exposed to polystyrene nanoplastics: Implications for intestinal health and glycolipid metabolism

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 472, P. 134478 - 134478

Published: April 30, 2024

Language: Английский

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Subchronic oral exposure to polystyrene microplastics affects hepatic lipid metabolism, inflammation, and oxidative balance in gilthead seabream (Sparus aurata)

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 279, P. 116455 - 116455

Published: May 20, 2024

Microplastics (MPs) pose a clear threat to aquatic organisms affecting their health. Their impact on liver homeostasis, as well the potential onset of nonalcoholic fatty disease (NAFLD), is still poorly investigated and remains almost unknown. The aim this study was evaluate outcomes subchronic exposure polystyrene MPs (PS-MPs; 1–20 μm; 0, 25, or 250 mg/kg b.w./day) lipid metabolism, inflammation, oxidative balance in gilthead seabreams (Sparus aurata Linnaeus, 1758) exposed for 21 days via contaminated food. PS-MPs induced an up-regulation mRNA levels crucial genes associated with synthesis storage (i.e., PPARy, Srebp1, Fasn) without modifications involved catabolism PPARα, HL, Pla2) transport metabolism (Fabp1) liver. increase CSF1R pro-inflammatory cytokines gene expression TNF-α IL-1β) also observed fish dose-dependent manner. These findings were confirmed by hepatic histological evaluations reporting evidence accumulation, necrosis. Moreover, caused impairment antioxidant defense system through alteration its enzymatic (catalase, superoxide dismutase, glutathione reductase) non-enzymatic (glutathione) components, resulting increased production reactive oxygen species (ROS) malondialdehyde (MDA), biomarkers damage. detoxifying enzymes inferred decreased Ethoxyresorufin-O-deethylase (EROD) activity glutathione-S-transferase (GST) at highest PS-MP dose. suggests that affect health seabream. dysfunction damage result from detrimental interplay damage, systems modifications, altering gut-liver axis homeostasis. This scenario suggestive involvement MP-induced effects progression

Language: Английский

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Developmental toxicity and mechanism of polychlorinated biphenyls 126 and nano-polystyrene combined exposure to zebrafish larvae

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 278, P. 116419 - 116419

Published: May 7, 2024

3,3′,4,4′,5-Pentachlorobiphenyl (PCB126) is the most toxic congener of dioxin-like polychlorinated biphenyls (DL PCBs), while nanoplastics (NPs) have recently emerged as significant marine pollutants, both posing threats to aquatic organisms and human health. They coexist in environment, but their comprehensive toxicological effects remain unclear. In this study, zebrafish embryos were simultaneously exposed PCB126 80-nanometer nanoplastyrene (NPS). Researchers utilized fluorescence microscopy, qPCR, histopathological examination, transcriptomic sequencing investigate developmental toxicity different concentrations NPS individually or combination on larvae. Results indicate that chorion significantly impedes accumulation (p < 0.05). It noteworthy barrier effect diminishes upon simultaneous exposure PCB126. experiment, semi-lethal concentration for larvae was determined be 6.33 μg/L. Exposure induces various deformities, primarily mediated through aryl hydrocarbon receptor (AHR). Similarly, also activates AHR, leading impairments. Furthermore, revealed similar gene expression trends larvae, combined exacerbates risk cancer more severe cardiac toxicity. At level, co-exposure adversely affects development This study contributes a deeper understanding vivo DL microplastics actual environments impact fish development.

Language: Английский

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Nanoplastics: Immune Impact, Detection, and Internalization after Human Blood Exposure by Single‐Cell Mass Cytometry

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 24, 2024

Abstract The increasing exposure to nanoplastics (NPs) raises significant concerns for human health, primarily due their potential bioaccumulative properties. While NPs have recently been detected in blood, interactions with specific immune cell subtypes and impact on regulation remain unclear. In this proof‐of‐concept study, model palladium‐doped polystyrene (PS‐Pd NPs) are utilized enable single‐cell mass cytometry (CyTOF) detection. size‐dependent of carboxylate (50–200 nm) is investigated across 15 primary subpopulations using CyTOF. By taking advantage Pd‐doping detecting PS‐Pd NPs, work evaluates immune‐cells at the level following blood exposure. This traces 37 immune‐cell from quantifying palladium atom count per by CyTOF while simultaneously assessing viability, functionality, uptake. These results demonstrate that can interact with, interfere translocate into several after vivo distribution experiments mice further confirmed accumulation cells within liver, spleen, particularly monocytes, macrophages, dendritic cells. findings provide valuable insights health.

Language: Английский

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Efficacy of DHA-enriched phosphatidylserine and its underlying mechanism in alleviating polystyrene nanoplastics-induced hepatotoxicity in mice

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 142, P. 113154 - 113154

Published: Sept. 14, 2024

Language: Английский

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Testicular Toxicity Assessment of Chronic Low-Dose Exposure to Polystyrene Nanoparticles in Multiexposure Models Using Drosophila

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Recent research has underscored the widespread presence of plastic in diverse ecosystems, prompting concerns about its potential long-term impacts on organisms. However, reproductive toxicity polystyrene nanoparticles (PSNPs) is contingent factors, such as drug concentrations, exposure duration, delivery method, and PSNP characteristics. Consequently, evaluation testicular stemming from chronic warrants a systematic investigation. This study extensively probed PSNPs testes using multiexposure models. Three distinct paradigms (adult, gestational, cross-generational exposure) were executed to assess PSNP-induced (80 nm) Drosophila. Nevertheless, spermatogenesis exhibited no discernible alterations following 75, 150, 300 μg/mL adult gestational Furthermore, did not perturb phenotype or offspring fertility F1 F4 generations. These findings imply that consumption low-dose may suffice induce dysfunction, providing fresh insights into dosage duration exposure.

Language: Английский

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Eco-friendly Nanoparticle Phytosynthesis via Plant Extracts: Mechanistic Insights, Recent Advances, and Multifaceted Uses

Nano TransMed, Journal Year: 2025, Volume and Issue: unknown, P. 100080 - 100080

Published: March 1, 2025

Language: Английский

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Metabolomic insights into the synergistic effects of nanoplastics and freeze-thaw cycles on Secale cereale L. seedling physiology

Journal of Environmental Management, Journal Year: 2025, Volume and Issue: 381, P. 125298 - 125298

Published: April 12, 2025

Language: Английский

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LncRNA-miRNA Interplay Regulate Intestinal Regeneration in the Sea Cucumber Apostichopus japonicus

Computational and Structural Biotechnology Journal, Journal Year: 2025, Volume and Issue: 27, P. 1383 - 1393

Published: Jan. 1, 2025

The sea cucumber Apostichopus japonicus, renowned for its remarkable ability to expel and regenerate internal organs within weeks, serves as a model organism regeneration research. However, studies on the role of non-coding RNAs, particularly long RNA (lncRNA), in intestinal remain limited. In this study, we identified performed differential expression analysis lncRNAs both normal intestines at 3 days post evisceration (dpe). A total 2361 were identified, 183 which differentially expressed (DE-lncRNAs). genes targeted by these lncRNAs, either cis- or trans-acting, involved oxidative stress, immune response, extracellular matrix remodeling, energy metabolism during regeneration. Notably, MSTRG.6200/miR-7847-3p MSTRG.18440/miR-4220-5p have been confirmed interacting lncRNA-miRNA pairs. These results suggest that are key regulators A. offering new insights into underlying mechanisms potential targets enhancing

Language: Английский

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