International Journal of Environmental Research and Public Health,
Journal Year:
2024,
Volume and Issue:
21(12), P. 1615 - 1615
Published: Dec. 2, 2024
This
Preferred
Reporting
Items
for
Systematic
Reviews
and
Meta-Analyses
(PRISMA)
systematic
review
synthesized
effects
of
background
levels
per-
polyfluorylalkyl
substance
(PFAS)
on
reproductive
health
outcomes
in
the
general
public:
fertility,
preterm
birth,
miscarriage,
ovarian
health,
menstruation,
menopause,
sperm
utero
fetal
growth.
The
inclusion
criteria
included
original
research
(or
primary)
studies,
human
subjects,
investigation
interest
following
non-occupational
exposures.
It
drew
from
four
databases
(Web
Science,
PubMed,
Embase
Health
Environmental
Research
Online
(HERO))
using
a
standardized
search
string
all
studies
published
between
1
January
2017
13
April
2022.
Risk
bias
was
assessed
by
two
independent
reviewers.
Data
were
extracted
reviewed
multiple
Each
study
summarized
under
its
outcome
terms
methodology
results
placed
context,
with
recommendations
future
research.
Of
1712
records
identified,
30
eligible,
total
27,901
participants
(33
datasets,
as
three
outcomes).
There
no
effect
PFAS
fertility.
weakly
to
moderately
increased
odds
birth
higher
perfluorooctane
sulfonic
acid
(PFOS)
levels;
same
miscarriage
perfluorooctanoic
(PFOA)
levels.
limited
yet
suggestive
evidence
link
early
menopause
primary
insufficiency;
menstrual
cycle
characteristics
inconsistent.
PCOS-
endometriosis-related
infertility,
respectively.
Sperm
motility
DNA
impaired
PFAS.
Fetal
growth
findings
may
be
used
inform
forthcoming
drinking
water
standards
policy
initiatives
regarding
compounds
water.
Future
reviews
would
benefit
more
recent
studies.
Larger
these
areas
are
warranted.
should
plan
large
cohorts
open
access
data
availability
capture
small
serve
public.
Funding:
Great
Lakes
Water
Authority
(Detroit,
MI),
Erb
Family
Foundation
through
Healthy
Urban
Waters
at
Wayne
State
University
CLEAR
Superfund
(NIH
P42ES030991).
Environmental Science & Technology,
Journal Year:
2024,
Volume and Issue:
58(31), P. 13624 - 13635
Published: July 25, 2024
Cohorts
of
pregnant
women
in
2018
and
2020
were
selected
to
explore
prenatal
exposure
perfluoroalkyl
polyfluoroalkyl
substances
(PFAS).
Maternal
serum
during
the
whole
pregnancy
(first
third
trimesters)
matched
cord
collected
for
analysis
50
PFAS.
Perfluorooctanoic
acid
(PFOA),
perfluorooctanesulfonic
(PFOS),
6:2
fluorotelomer
sulfonic
(6:2
FTS)
dominant
PFAS
both
maternal
serum.
The
median
∑PFAS
concentration
was
14.18
ng/mL,
observed
decline
from
first
trimester
trimester.
transplacental
transfer
efficiencies
(TTE)
29
comprehensively
assessed,
a
"U"-shaped
trend
TTE
values
with
increasing
molecular
chain
length
carboxylic
(PFCA)
this
study.
Moreover,
concentrations
9-chlorohexadecafluoro-3-oxanonane-1-sulfonic
Cl-PFESA),
perfluorononanoic
(PFNA),
perfluorodecanoic
(PFDA),
perfluoroundecanoic
(PFUdA),
perfluorododecanoic
(PFDoA),
PFOS,
hexafluoropropylene
oxide
dimer
(HFPO-DA)
cohort
significantly
lower
than
those
cohort,
declining
by
about
23.85-43.2%
(
Journal of Hazardous Materials,
Journal Year:
2024,
Volume and Issue:
485, P. 136780 - 136780
Published: Dec. 5, 2024
Per-
and
polyfluoroalkyl
substances'
(PFAS)
extreme
persistence
has
been
linked
to
many
adverse
effects
on
human
health
including
increased
risk
of
certain
cancers.
This
study
presents
the
development
validation
a
new,
highly
sensitive
method
for
quantification
32
PFAS
in
serum
using
online
solid-phase
extraction
(SPE)
coupled
with
ultra-high
performance
liquid
chromatography-high
resolution
mass
spectrometry
(UHPLC-HRMS).
Legacy
emerging
were
targeted.
Main
steps
sample
pretreatment
include
protein
precipitation
(PP),
pellet
rinsing,
centrifugation,
preconcentration
through
solvent
evaporation,
SPE
weak
anion-exchange
polymeric
sorbent.
The
PP
pellet-rinsing
procedures
optimized
comprehensive
exploration
combinations.
Following
this,
that
offers
best
compromise
targeted
was
identified
principal
component
analysis.
demonstrated
excellent
linearity
(R²
=
0.977-0.997)
limits
ranging
from
8.9
27
ng/L,
5
15
times
lower
than
previous
methods.
Precision
(intraday
2.6-14.0
%
interday
1.3-11.0
relative
standard
deviation)
accuracy
(recoveries
72.7-106
%)
robust.
validated
accordance
ISO/IEC
17025
successfully
applied
five
samples,
confirming
its
suitability
high-throughput
profiling
biomonitoring
studies.
is
first
use
simultaneous
determination
broad
range
PFAS,
ether
congeners
such
as
perfluoro(2-ethoxyethane)
sulfonic
acid
Nafion
byproduct
2.
Furthermore,
control
charts
employed
assess
instrument
during
routine
analysis
implement
necessary
actions.
The Science of The Total Environment,
Journal Year:
2024,
Volume and Issue:
915, P. 170096 - 170096
Published: Jan. 14, 2024
Per-
and
polyfluoroalkyl
substances
(PFAS)
are
a
group
of
synthetic
chemicals
with
potential
adverse
health
effects.
Information
concerning
PFAS
concentrations
in
relation
to
pregnancy
is
scarce
South
America
non-existent
Argentina.
International Journal of Hygiene and Environmental Health,
Journal Year:
2025,
Volume and Issue:
264, P. 114522 - 114522
Published: Jan. 21, 2025
Per-
and
poly-fluoroalkyl
Substances
(PFAS)
have
been
used
for
decades
in
countless
households
industrial
products.
Many
PFAS
do
not
degrade
are
thus
ubiquitous
the
environment
within
organisms.
Humans
primarily
exposed
to
through
ingestion
inhalation,
such
exposure
has
associated
with
several
health
effects.
Some
accumulate
top
layer
of
seawater
seafoam
up
100,000
times
concentration
bulk
seawater.
No
studies
investigated
whether
or
aerosols
by
surfing
other
water
activities
is
a
higher
burden.
This
study
aimed
measure
concentrations
blood
34
Danish
surfers
investigate
effect
annual
hours
on
these
concentrations.
A
cross-sectional
questionnaire-based
from
West
Coast
Denmark
was
conducted
possible
association
between
serum
including
PFOA,
PFOS,
PFNA,
PFDA
PFHxS.
All
had
measurable
their
blood.
However,
were
increased
Unadjusted
subgroup
analyses
showed
statistically
significant
associations
male
sex
consumption
meat
free-ranging
animals
blood,
although
might
be
driven
factors.
descriptively
explored
distribution
different
subgroups
based
potential
risk
factors
exposure.
Even
though
no
found,
suspected
To
prevent
exposures
that
lead
adverse
effects,
further
needed.
Alzheimer s & Dementia,
Journal Year:
2025,
Volume and Issue:
21(5)
Published: May 1, 2025
Abstract
Per‐
and
polyfluoroalkyl
substances
(PFAS)
are
ubiquitous
persistent
organic
pollutants.
The
neurotoxic
cardiometabolic
effects
of
PFAS
well
documented,
leading
to
the
hypothesis
that
exposure
increases
dementia
risk.
However,
empirical
data
on
in
relation
cognitive
impairment
weak,
limited,
inconsistent.
This
report
reviews
literature
provides
a
rationale
overview
VascCog
Longitudinal
Study,
new
study
using
population‐based
Northern
Manhattan
Study
cohort,
prospectively
examine
serum
concentrations
13
lipids,
carotid
atherosclerosis,
impairment,
dementia.
We
hypothesize
deleteriously
impact
cognition
through
pathway
involving
hyperlipidemia
atherosclerosis.
Rigorous
examination
is
needed
inform
public
health
policies
PFAS‐containing
products,
support
regulations
reduce
community
exposure,
provide
avenues
protect
at
individual
levels.
Highlights
risk
factors
neurotoxicity.
Data
controversial.
mechanistic
can
policy.
