Environmental Chemistry Letters, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 30, 2024
Language: Английский
Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: 73(9), P. 5526 - 5536
Published: Feb. 21, 2025
Silicon dioxide particles (SiO2) have been widely used in food additives. Increasing data demonstrate that SiO2 can cause multisystem damage through oxidative stress. Quercetin (Que) is one of the most popular nutritional antioxidants. Ferroptosis reduces level angiogenesis. However, whether Que alleviates inhibition testicular angiogenesis by relieving SiO2-induced ferroptosis via ROS/PPARγ unclear. Based on this, we established SiO2-exposed mice and C166 cell models added stress activators Sanguinarine chloride (SAN), PPARγ inhibitor GW9662, activator Erastin to vitro. The results showed exposure group had antioxidant dysfunction; was significantly downregulated; levels were increased; reduced. treatment alleviate these changes. addition SAN, reduced effects activating stress, inhibiting PPARγ, ferroptosis, respectively. In general, ROS/PPARγ, thus restoring mice.
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: May 5, 2025
Pulmonary fibrosis is a disease that severely affects the patients' life quality, characterized by lung tissue remodeling and functional impairment. Recent research has found NLRP3 inflammasome plays an important role in pathogenesis of pulmonary fibrosis. Although existing researches have revealed potential fibrosis, many mysteries still remain regarding its specific mechanisms clinical applications. This article aims to review action related signaling pathways, latest progress on as therapeutic target, hopes providing new ideas directions for future treatment.
Language: Английский
Citations
0
Life Sciences, Journal Year: 2024, Volume and Issue: 352, P. 122811 - 122811
Published: June 9, 2024
Macrophages play key roles in atherosclerosis progression, and an imbalance M1/M2 macrophages leads to unstable plaques; therefore, macrophage polarization-targeted treatments may serve as a new approach the treatment of atherosclerosis. At present, there is little research on nanotechnology. Proteolysis-targeting chimera (PROTAC) technology, targeted protein degradation mediates target proteins has been widely promoted preclinical clinical applications novel therapeutic modality. This review summarizes recent studies nanotechnology, focusing mechanism advantages PROTACs polarization for
Language: Английский
Citations
3
Chemosphere, Journal Year: 2025, Volume and Issue: 382, P. 144470 - 144470
Published: May 15, 2025
Language: Английский
Citations
0
Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 120061 - 120061
Published: May 1, 2025
Language: Английский
Citations
0
Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)
Published: Dec. 5, 2024
Pyroptosis, an inflammatory regulated cell death (RCD) mechanism, is characterized by cellular swelling, membrane rupture, and subsequent discharge of contents, exerting robust proinflammatory effects. Recent studies have significantly advanced our understanding pyroptosis, revealing that it can be triggered through inflammasome- caspase-independent pathways, interacts intricately with other RCD pathways (e.g., necroptosis, ferroptosis, cuproptosis). The pathogenesis pulmonary fibrosis (PF), including idiopathic (IPF) interstitial lung diseases, involves a multifaceted interplay factors such as pathogen infections, environmental pollutants, genetic variations, immune dysfunction. This chronic progressive disease persistent inflammation, extracellular matrix (ECM) accumulation, fibrotic alveolar wall thickening, which potentially contribute to deteriorated function. Despite recent advances in the mechanisms regulates PF are not entirely elucidated, effective strategies improve clinical outcomes remain unclear. review strives deliver comprehensive overview biological functions molecular exploring its roles PF. Furthermore, examines potential biomarkers therapeutic agents for anti-fibrotic treatments.
Language: Английский
Citations
2
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 14(4)
Published: Oct. 9, 2024
Silicosis is a severe lung disease characterized by diffuse pulmonary fibrosis, for which there currently no effective treatment. Pirfenidone (PFD) shows great antifibrotic potential but clinically hindered low bioavailability and gastrointestinal side effects. To address these limitations, this study develops PFD delivery system (PFD-Exo) using J774A.1 macrophage-derived exosomes. Firstly, loaded via sonication, then PFD-Exo Raman spectral imaging UV absorption spectroscopy. Finally, in vitro vivo silicosis models are established to evaluate its Results show that outperforms free inhibiting TGF-β1-induced transdifferentiation of primary fibroblasts vitro. In mouse model silicosis, found be accumulated the lungs following intratracheal administration significantly ameliorates inflammation fibrosis while minimizing Mechanistic studies reveal modulates TGF-β signaling pathway downregulating SMAD3 upregulating SMAD7 NOGGIN. conclusion, provides first evidence exosomes as an treatment offers promising strategy other refractory diseases.
Language: Английский
Citations
1
Toxicology Letters, Journal Year: 2024, Volume and Issue: 398, P. 49 - 54
Published: June 12, 2024
Language: Английский
Citations
0
Phytomedicine, Journal Year: 2024, Volume and Issue: 135, P. 156092 - 156092
Published: Sept. 28, 2024
Language: Английский
Citations
0
Environmental Chemistry Letters, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 30, 2024
Language: Английский
Citations
0