Unmasking the Invisible Threat: Biological Impacts and Mechanisms of Polystyrene Nanoplastics on Cells DOI Creative Commons

Wenxia Bu,

Cui Ye, Yan Jin

et al.

Toxics, Journal Year: 2024, Volume and Issue: 12(12), P. 908 - 908

Published: Dec. 14, 2024

Polystyrene nanoplastics (PS-NPs), a pervasive component of plastic pollution, have emerged as significant environmental and health threat due to their microscopic size bioaccumulative properties. This review systematically explores the biological effects mechanisms PS-NPs on cellular systems, encompassing oxidative stress, mitochondrial dysfunction, DNA damage, inflammation, disruptions in autophagy. Notably, induce multiple forms cell death, including apoptosis, ferroptosis, necroptosis, pyroptosis, mediated through distinct yet interconnected molecular pathways. The also highlights various factors that influence cytotoxicity PS-NPs, such particle size, surface modifications, co-exposure with other pollutants, protein corona formation. These complex interactions underscore extensive potentially hazardous impacts health. findings presented here emphasize need for continued research underlying PS-NP toxicity development effective strategies mitigating effects, thereby informing regulatory frameworks aimed at minimizing risks.

Language: Английский

Abamectin Causes Neurotoxicity in Zebrafish Embryos DOI Open Access
Zhang Hong-ying, Yulong Liu, Yukun Huang

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(1), P. 349 - 349

Published: Jan. 3, 2025

Abamectin is an insecticide, miticide and nematicide that has been extensively used in agriculture for many years. The excessive use of abamectin inevitably pollutes water soil might even cause adverse effects on aquatic biota. However, it currently unclear how exposure causes neurotoxicity organisms. Herein, the early neural system development was assessed zebrafish embryos following exposure. After treatment with a concentration gradient (0.055, 0.0825, 0.11 mg/L), survival rate, average heart pericardial edema area yolk sac were all documented (96 hpf). It found after exposure, embryonic brain impaired, motor behaviors also affected. fluorescence intensity reduced transgenic (Eno2: GFP). activities acetylcholinesterase (AChE) ATPase decreased, expression neurodevelopment-related genes, such as sox10, gap43, grin1b, abat, gad1b, grin2b, nestin glsa, inhibited embryo abamectin. Furthermore, reactive oxygen species (ROS) triggered upon to along accumulation ROS, eventually resulting neuroapoptosis developing brain. In conclusion, neurodevelopmental toxicity caused by oxidative stress-induced apoptosis

Language: Английский

Citations

0
Co-Existing Nanoplastics Further Exacerbates the Effects of Triclosan on the Physiological Functions of Human Serum Albumin DOI Creative Commons
Yan Bao, Yaoyao Wang, Hongbin Liu

et al.

Life, Journal Year: 2025, Volume and Issue: 15(1), P. 112 - 112

Published: Jan. 16, 2025

The potential health risks posed by the coexistence of nanoplastics (NPs) and triclosan (TCS) have garnered significant attention. However, effects underlying mechanisms NPs TCS on key functional proteins at molecular level remain poorly understood. This study reports effect polystyrene (PSNPs) binding to human serum albumin (HSA) using multispectral methods simulation systems. experimental results show that significantly inhibits HSA esterase activity, with exacerbating inhibition in presence PSNPs, which is attributed alteration conformation microenvironment amino acid residues induced PSNPs. Molecular docking site marker competitive studies indicate predominantly binds I subdomain Sudlow II PSNPs does not affect sites. Spectra analyses quenching mechanism between belongs static type change fluorescence type. conformational alterations are further enhanced indicating enhance making more accessible provides valuable information about toxicity case co-exposure.

Language: Английский

Citations

0
Exposure to polystyrene nanoplastics induces lysosomal enlargement and lipid droplet accumulation in KGN human ovarian granulosa cells DOI
Yunbo Zhang, Barbara F. Hales, Bernard Robaire

et al.

Archives of Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Language: Английский

Citations

0
Micro-nanoplastics pollution and mammalian fertility: a systematic review and meta-analysis DOI Creative Commons

Alessandro Marino Volsa,

Eleonora Iacono, Barbara Merlo

et al.

Theriogenology, Journal Year: 2025, Volume and Issue: 238, P. 117369 - 117369

Published: Feb. 26, 2025

Language: Английский

Citations

0
Graphene Oxide Nanosheets Induce Mitochondrial Toxicity in Human Ovarian Granulosa Cells: Implications for Female Reproductive Health DOI Creative Commons

Min Li,

Hedong Lu,

Chunya Ye

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 4461 - 4479

Published: April 1, 2025

Graphene oxide (GO) has promising biomedical applications, but its potential toxicity to the female reproductive system is underexplored. This study investigates short-term effects of a single dose GO nanosheets on human ovarian granulosa cells, focusing mitochondrial damage. First, cell viability was detected by CCK-8 and apoptosis flow cytometry assess cytotoxicity KGN. Second, reactive oxygen species (ROS), membrane (MMP), morphology were observed confocal microscopy, sub-mitochondrial structure transmission electron microscopy (TEM), quantitative analysis ATP complex I enzyme activity luminosity value autophagy KGN cells. The 72h half-maximum effective concentration (EC50) determined be 29.73 μg/mL. induced death in dose-dependent manner, with significant even at low doses (1 μg/mL). Exposure concentrations resulted abnormal function, including breakage, damage, reduced cristae, enhanced autophagy, decreased production, MMP, enzymatic I. Mitochondrial function returned normal levels day 7 after cells left GO-exposed environment. demonstrates that exposure low-dose causes damage highlighting need for further research safety GO, particularly regarding health. However, GO-induced transient highly likely negatively affect reserve which needs verified animal models.

Language: Английский

Citations

0
The potential of microplastics acting as vector for triclosan in aquatic environments DOI
Naveen Chand, Stefan Krause, Sanjeev Kumar Prajapati

et al.

Aquatic Toxicology, Journal Year: 2025, Volume and Issue: 284, P. 107381 - 107381

Published: April 23, 2025

Language: Английский

Citations

0
Insights into the synergistic toxicity mechanisms caused by nano- and microplastics with triclosan using a dose-dependent functional genomics approach in Saccharomyces cerevisiae DOI

Linhao Zong,

Xiaoyang Wang,

Miaomiao Huo

et al.

Chemosphere, Journal Year: 2024, Volume and Issue: 362, P. 142629 - 142629

Published: June 15, 2024

Language: Английский

Citations

1
Unmasking the Invisible Threat: Biological Impacts and Mechanisms of Polystyrene Nanoplastics on Cells DOI Creative Commons

Wenxia Bu,

Cui Ye, Yan Jin

et al.

Toxics, Journal Year: 2024, Volume and Issue: 12(12), P. 908 - 908

Published: Dec. 14, 2024

Polystyrene nanoplastics (PS-NPs), a pervasive component of plastic pollution, have emerged as significant environmental and health threat due to their microscopic size bioaccumulative properties. This review systematically explores the biological effects mechanisms PS-NPs on cellular systems, encompassing oxidative stress, mitochondrial dysfunction, DNA damage, inflammation, disruptions in autophagy. Notably, induce multiple forms cell death, including apoptosis, ferroptosis, necroptosis, pyroptosis, mediated through distinct yet interconnected molecular pathways. The also highlights various factors that influence cytotoxicity PS-NPs, such particle size, surface modifications, co-exposure with other pollutants, protein corona formation. These complex interactions underscore extensive potentially hazardous impacts health. findings presented here emphasize need for continued research underlying PS-NP toxicity development effective strategies mitigating effects, thereby informing regulatory frameworks aimed at minimizing risks.

Language: Английский

Citations

0