Integrated histological, physiological, and transcriptome analysis reveals the post-exposure recovery mechanism of nitrite in Litopenaeus vannamei

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 281, P. 116673 - 116673

Published: July 3, 2024

Nitrite is one of the most common toxic pollutants in intensive aquaculture and harmful to aquatic animals. Recovery mechanisms post exposure nitrite shrimp have rarely been investigated. This study focuses on effect post-exposure recovery histological physiological aspects Litopenaeus vannamei utilizes transcriptome sequencing analyze molecular adaptation exposure. The results showed that histopathological damage hepatopancreas gills caused by short-term resolved with recovery. total antioxidant capacity (T-AOC), superoxide dismutase (SOD), catalase (CAT) were significantly reduced during returned control level after recovery, malondialdehyde (MDA) levels opposite them. Restoration system mitigated oxidative damage. activity immuno-enzymes acid phosphatase (ACP) alkaline (AKP), which can be recovered level. L. adapt regulating Na+/K+-ATPase (NKA) activity. Transcriptome analysis revealed activation glutathione metabolism peroxisomal pathways facilitated mitigation period. Excessive activates apoptosis p53 pathways. Additionally, Sestrin2 STEAP4 may a positive shrimp. These provide evidence for ability vannamei. complement knowledge under

Language: Английский

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Mechanism of blocking the glutamate pathway to exacerbate oxidative stress, ammonia toxicity and metabolic disorders in crucian carp (Carassius auratus) under saline-alkaline exposure

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, Journal Year: 2025, Volume and Issue: 291, P. 110146 - 110146

Published: Feb. 17, 2025

Language: Английский

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Integration of microbiomics and metabolomics reveals energy metabolism imbalance in crucian carp (Carassius auratus) under saline-alkaline exposure

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, Journal Year: 2025, Volume and Issue: 291, P. 110145 - 110145

Published: Feb. 20, 2025

Language: Английский

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α-Ketoglutarate modulates the mechanisms of toxicity in crucian carp kidneys chronically exposed to NaHCO3: Metabolomics insights

Comparative Biochemistry and Physiology Part D Genomics and Proteomics, Journal Year: 2025, Volume and Issue: 55, P. 101466 - 101466

Published: March 4, 2025

Language: Английский

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Polysaccharide‐Induced Immunoregulation, Signaling Pathways, and Stress Mitigation in Aquaculture Animals: A Review

Reviews in Aquaculture, Journal Year: 2025, Volume and Issue: 17(2)

Published: March 1, 2025

ABSTRACT Aquaculture, encompassing the cultivation of diverse saltwater and freshwater fish shellfish species, is rapidly expanding, driven by pressing need for sustainable food production. However, intensified farming practices often lead to significant economic losses due mortality from infectious diseases stress‐related conditions. Consequently, enhancing immune responses farmed species has become vital management. This encouraged a growing interest in natural eco‐friendly bioactive compounds as alternatives synthetic chemicals disease prevention. Among these, polysaccharides various sources have emerged promising candidates, administered through dietary inclusion, intraperitoneal injection, or immersion. As prebiotics, these enhance immunity overall health aquaculture modulating both innate adaptive responses, including lysozyme activity, phagocytosis, cytokine review critically examines latest advances polysaccharide‐induced immunoregulation, highlighting their influence on key signaling pathways, which play pivotal roles modulation. Additionally, potential mitigate stress caused environmental factors discussed, demonstrating ability growth performance resistance. The collective findings underscore value antibiotics, aligning with increasing consumer demand antibiotic‐free products supporting advancement global sustainability.

Language: Английский

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Potential Natural Plant Polysaccharides for Use as Feed Additives in Aquaculture: Structure–Activity Relationship, Benefits, and Restrictions

Reviews in Aquaculture, Journal Year: 2025, Volume and Issue: 17(2)

Published: March 1, 2025

ABSTRACT Some potential natural plant polysaccharides (PNPP) exhibit a diverse array of beneficial biological activities and are increasingly utilized as feed additives in environmentally sustainable aquaculture. This review summarizes the extraction purification methods, well processes involved obtaining polysaccharides. Subsequently, we provide an in‐depth discussion on relationship between structural characteristics PNPP their associated activities. Following this, highlight advantageous effects Astragalus polysaccharides, Lycium barbarum other within aquaculture settings. We also briefly elucidate pathways mechanisms underlying these based properties. Finally, outline limitations currently faced applying to aquatic farming while proposing future directions for development this field. aims enhance understanding offers theoretical foundation forthcoming research applications

Language: Английский

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Effects of Alkalinity Stress on Amino Acid Metabolism Profiles and Oxidative-Stress-Mediated Apoptosis/Ferroptosis in Hybrid Sturgeon (Huso dauricus ♀ × Acipenser schrenckii ♂) Livers

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10456 - 10456

Published: Sept. 27, 2024

Alkaline water is toxic to cultured aquatic animals that frequently live in pH-neutral freshwater. Overfishing and habitat destruction have contributed the decline wild sturgeon population; consequently, domestic hybrid has become an increasingly important commercial species China. Hybrid sturgeons are widely alkaline water, but little known about effects of alkalinity stress on liver tissues. We exposed four concentrations (3.14 ± 0.02 mmol/L, 7.57 0.08 11.78 0.24 mmol/L 15.46 0.48 mmol/L). Histopathology, biochemical index assessment, gene expression level detection metabolomics analysis were used investigate negative functions following exposure NaHCO3. Livers exhibited severe tissue injury clear apoptotic characteristics. With increased concentrations, hepatic superoxide dismutase, catalase, glutathione peroxidase phosphatase activities significantly decreased a dose-dependent manner. NaHCO3 up-regulated transcriptional levels apoptosis/ferroptosis-related genes livers. Similarly, trends interleukin-1β heat shock protein also high-alkalinity environments. However, complement 3 (p < 0.05). Hepatic untargeted revealed alteration conditions various metabolites associated with antioxidant response, ferroptosis process amino acid metabolism (such as beta-alanine metabolism; alanine, aspartate glutamate glycine, serine threonine metabolism). These data provided evidence impaired immune integrity tissues by mediating oxidative-stress-mediated apoptosis ferroptosis. Our results shed light breeding welfare promote economic development fisheries

Language: Английский

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Effects of three naturally extracted polysaccharides on the growth, antioxidant capacity, and intestinal health during early-stage of juvenile lined seahorses (Hippocampus erectus) via trophic transfer

Aquaculture, Journal Year: 2024, Volume and Issue: unknown, P. 741920 - 741920

Published: Nov. 1, 2024

Language: Английский

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