Genomic Features and Antimicrobial Activity of Phaeobacter inhibens Strains from Marine Biofilms DOI Creative Commons

Han Cui,

Jie Lu, Wei Ding

et al.

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(11), P. 492 - 492

Published: Oct. 31, 2024

Members of the genus

Language: Английский

Vibrio alginolyticus AbY-1904: A neotype pathogen and its pathogenic characterization in Haliotis discus hannai DOI

Lirong Chang,

Zhongcheng Wei,

Longfei Lu

et al.

Aquaculture, Journal Year: 2025, Volume and Issue: unknown, P. 742322 - 742322

Published: Feb. 1, 2025

Language: Английский

Citations

0
Multiple toxicological effects of paralytic shellfish toxins and their producing microalgae on diverse aquatic organisms DOI Creative Commons
Xiaoqing Xu, Jiangbing Qiu, Peiyao Li

et al.

Water Biology and Security, Journal Year: 2025, Volume and Issue: unknown, P. 100402 - 100402

Published: April 1, 2025

Language: Английский

Citations

0
Revealing the effects of polystyrene microplastics and di(2-ethylhexyl) phthalate on mussels:An evidence chain of gill-intestine-hemolymph DOI

Yiming Gao,

Xiaopeng Pang, James Kar‐Hei Fang

et al.

Environmental Research, Journal Year: 2025, Volume and Issue: 279, P. 121732 - 121732

Published: May 1, 2025

Language: Английский

Citations

0
Acute nitrite exposure causes gut microbiota dysbacteriosis and proliferation of pathogenic Photobacterium in shrimp DOI Creative Commons
Yongming Wang, Yi Shu, Yue Sun

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 283, P. 116829 - 116829

Published: Aug. 5, 2024

Nitrite exposure has become a significant concern in the aquaculture industry, posing severe threat to aquatic animals such as shrimp. While studies have reported adverse effects of nitrite on shrimp growth, part played by gut microbiota mortality resulting from is poorly understood. Here, bacterial community were investigated using 16S rRNA amplicon sequencing, isolation, genomic analysis, and infection experiments. Compared control_healthy group, changes composition nitrite_dead group associated with reduced abundance specific beneficial bacteria increased certain pathogenic bacteria. Notably, members Photobacterium genus found be significantly enriched group. Genomic analysis representative strain (LvS-8n3) revealed variety genes encoding toxins, including hemolysin, adhesin, phospholipase. Furthermore, it was also that LvS-8n3 exhibits strong pathogenicity, probably due its high production factors ability utilize for proliferation. Therefore, proliferation species appears pivotal driving caused exposure. These findings provide novel insights into disease mechanism under conditions environmental change.

Language: Английский

Citations

3
Bioprospecting of culturable marine biofilm bacteria for novel antimicrobial peptides DOI Creative Commons

Shen Fan,

Peng Qin, Jie Lu

et al.

iMeta, Journal Year: 2024, Volume and Issue: 3(6)

Published: Oct. 17, 2024

Antimicrobial peptides (AMPs) have become a viable source of novel antibiotics that are effective against human pathogenic bacteria. In this study, we construct bank culturable marine biofilm bacteria constituting 713 strains and their nearly complete genomes predict AMPs using ribosome profiling deep learning. Compared with previous approaches, has improved the identification validation small open reading frames (sORFs) for AMP prediction. Among 80,430 expressed sORFs, 341 identified as candidate high probability. Most potential less than 40% similarity in amino acid sequence compared to those listed public databases. Furthermore, these associated bacterial groups not previously known produce AMPs. Therefore, our learning model acquired characteristics unfamiliar Chemical synthesis 60 sequences yields 54 compounds antimicrobial activity, including potent inhibitory effects on various drug-resistant pathogens. This study extends range by investigating microbiomes approach, accelerating discovery.

Language: Английский

Citations

3
Genomic Analysis of Novel Sulfitobacter Bacterial Strains Isolated from Marine Biofilms DOI Creative Commons

Han Cui,

Shen Fan,

Wei Ding

et al.

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(7), P. 289 - 289

Published: June 22, 2024

Bacteria from the genus Sulfitobacter are distributed across various marine habitats and play a significant role in sulfur cycling. However, metabolic features of inhabiting biofilms still not well understood. Here, complete genomes paired metatranscriptomes eight strains, isolated on subtidal stones, have been analyzed to explore their central energy metabolism potential secondary metabolite biosynthesis. Based average nucleotide identity phylogenetic analysis, strains were classified into six novel species two strains. The reconstruction pathways indicated that all had Entner–Doudoroff pathway, pentose phosphate diverse for amino acid metabolism, suggesting presence an optimized carbon metabolism. Pangenome analysis further revealed differences between gene cluster distribution patterns among functional variation. Moreover, total 47 biosynthetic clusters discovered, which 37 families showed low similarity with previously documented clusters. Furthermore, metatranscriptomic expressions key genes involved biosynthesis ribosomal peptides situ biofilms. Overall, this study sheds new light features, adaptive strategies, value genome mining group biofilm-associated bacteria.

Language: Английский

Citations

2
Genomic Features and Antimicrobial Activity of Phaeobacter inhibens Strains from Marine Biofilms DOI Creative Commons

Han Cui,

Jie Lu, Wei Ding

et al.

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(11), P. 492 - 492

Published: Oct. 31, 2024

Members of the genus

Language: Английский

Citations

0