The potential mechanisms underlying phthalate-induced hypospadias: a systematic review of rodent model studies DOI Creative Commons

Youtian Zhang,

Jian Wang, Hongchao Yang

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 4, 2024

Maternal exposure to environmental endocrine disruptors, such as phthalates, during pregnancy is a significant risk factor for the development of hypospadias. By consolidating existing research on mechanisms by which phthalates induce hypospadias in rodent models, this systematic review aims organize and analyze discovered their potential connections.

Language: Английский

The role of di-(2-ethylhexyl) phthalate in cancer initiation and progression: Mechanisms and health implications DOI
Xinrui Zhou, Ye Wei, Jiapeng Xu

et al.

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 959, P. 178285 - 178285

Published: Jan. 1, 2025

Language: Английский

Citations

0
Combined Molecular Toxicity Mechanism of Phthalate Mixtures DOI Open Access
Yiyun Liu, De‐Sheng Pei

Published: Jan. 14, 2025

Phthalates (PAEs) are one of the most widely used compounds in polymer products, commonly as additives food packaging, personal care insecticides, and agricultural films. In plastic industry, they mainly plasticizers to increase flexibility durability polyvinyl chloride (PVC) plastics. Due noncovalent binding PAEs with can migrate from interior product through wear leaching, gradually continuously releasing into environment, causing widespread pollution environmental media such atmosphere, water, soil, sediment, leading increasing exposure risk human. Some research has shown that have a chemical structure similar sex hormones endocrine-disrupting effects, affecting fertility reproductive health both females males. addition, neurotoxicity, hepatotoxicity, carcinogenicity been reported, so classified harmful chemicals (EDCs) emerging pollutants. However, challenge is appearance these does not exist single compound, typically exposed people form mixtures. Because instability PAEs, even be metabolized by organisms produce more toxic metabolites. Although extensive studies on several there limited understanding their interactions. Therefore, this chapter introduces combined toxicological cases PAE co-exposure.

Language: Английский

Citations

0
Do emerging alternatives pose similar soil ecological risks as traditional plasticizers? A multi-faceted analysis using earthworms as a case study DOI

Huijuan Lv,

Baoyan Mu,

Haixia Xu

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 487, P. 137298 - 137298

Published: Jan. 20, 2025

Language: Английский

Citations

0
The potential mechanisms underlying phthalate-induced hypospadias: a systematic review of rodent model studies DOI Creative Commons

Youtian Zhang,

Jian Wang, Hongchao Yang

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 4, 2024

Maternal exposure to environmental endocrine disruptors, such as phthalates, during pregnancy is a significant risk factor for the development of hypospadias. By consolidating existing research on mechanisms by which phthalates induce hypospadias in rodent models, this systematic review aims organize and analyze discovered their potential connections.

Language: Английский

Citations

0