Metabolomics’ Change Under β-Cypermethrin Stress and Detoxification Role of CYP5011A1 in Tetrahymena thermophila

Metabolites, Journal Year: 2025, Volume and Issue: 15(3), P. 143 - 143

Published: Feb. 20, 2025

Background: β-cypermethrin (β-CYP) exhibits high toxicity to aquatic organisms and poses significant risks ecosystems. Tetrahymena thermophila, a protozoa widely distributed in environments, can tolerate concentrations of β-cypermethrin. However, the comprehensive detoxification mechanisms remain poorly understood Tetrahymena. Methods: Untargeted metabolomics was used explore T. thermophila under β-CYP stress. Results: Trehalose, maltose, glycerol, D-myo-inositol were upregulated exposure Furthermore, expression level CYP5011A1 treatment. knockout mutants resulted decreasing proliferation rate The valine–leucine isoleucine biosynthesis glycine–serine threonine metabolism significantly affected, with changed amino acids including serine, isoleucine, valine. Conclusions: These findings confirmed that develops tolerance by carbohydrate reprogramming Cyp5011A1 improves cellular adaptations influencing acid metabolisms. Understanding these inform practices aimed at reducing adverse effects agricultural chemicals on microbial environmental health.

Language: Английский

The Sub‐Acute Potential Risk of Oxamyl in Male Albino Rats

Environmental Toxicology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 28, 2024

ABSTRACT The current study aimed to investigate the sub‐acute effects of oxamyl on male Albino rats following oral administration either 0.031 or 0.31 mg/kg/day for 14 consecutive days. findings demonstrated that produced a significant impact most examined blood profile and biomarkers, along with progressive discernible alterations in histology organs. According results obtained, potential mechanisms by which causes its toxic are identified as inflammation indices, inhibition transaminases, alkaline phosphatase, antioxidant enzymes, well production thiobarbituric acid reactive substances (TBARs) organs treatment based histopathological examinations. Due substantial genetic similarities between humans, it is therefore anticipated will have comparable detrimental humans.

Language: Английский

Effects of GroMore® Program on Rice Yield and GHG Emissions in a Korean Paddy Rice

Agronomy, Journal Year: 2024, Volume and Issue: 14(10), P. 2448 - 2448

Published: Oct. 21, 2024

The agronomic benefits of pesticides combined with amino acid application to increase rice production have been recognized, but they are still not well-known for greenhouse gas (GHG) emissions and mitigation in irrigated paddy fields. Thus, this study was conducted investigate the effects pesticide on yield methane (CH4) a Korean paddy. A field experiment five levels: none (no application, T1), different conventional practices (combined insecticides fungicide, T2 T3), GroMore® programs insecticides, fungicides, acids, T4 T5). Rice grain components were obtained using measurements. To determine intensity (GHGI) each treatment, CH4 measured throughout growing period. Results showed that chemical applications combination acids higher number panicles per plant compared T1, T2, T3, while T5 no difference filled spikelets except T2. T3 lower respective cumulative by 30% 32% during entire season, (T1). Meanwhile, N2O negligible all treatments because flooded most season. results impact relatively GHG presented. In conclusion, GHGI values.

Language: Английский