Rutin Alleviates Zearalenone-Induced Endoplasmic Reticulum Stress and Mitochondrial Pathway Apoptosis in Porcine Endometrial Stromal Cells by Promoting the Expression of Nrf2 DOI Creative Commons

Chuangjiang Chen,

Chenlong Wang, Hui Jiang

et al.

Toxins, Journal Year: 2024, Volume and Issue: 17(1), P. 7 - 7

Published: Dec. 26, 2024

Zearalenone (ZEA) is a mycotoxin commonly found in moldy cereals and has range of toxic effects that have seriously affected animal husbandry. Rutin, natural flavonoid with antioxidant activities, been studied for its potential involvement mitigating ZEA-induced apoptosis porcine endometrial stromal cells (ESCs) molecular mechanism, particularly concerning the expression Nrf2. This study investigates pathways by which rutin alleviates ESC apoptosis, focusing on role Experimental data reveal ZEA suppresses Nrf2 nuclear translocation reduces mitochondrial membrane (MMP), leading to oxidative stress, endoplasmic reticulum stress (ERS), pathway-driven apoptosis. Notably, mitigates through activation. These findings highlight as critical factor rutin's protective against offering valuable insights clinical prevention treatment toxicity.

Language: Английский

Mycotoxins in Food: Cancer Risks and Strategies for Control DOI Creative Commons
Alice Njolke Mafe, Dietrich Büsselberg

Foods, Journal Year: 2024, Volume and Issue: 13(21), P. 3502 - 3502

Published: Oct. 31, 2024

Mycotoxins are toxic compounds produced by fungi such as

Language: Английский

Citations

18
Insights into the zearalenone degradation performance and pathway by Gordonia hydrophobica HAU421 and characterization of a novel lactonohydrolase involved DOI
Xiaohong Chen, Zeyun Li,

Xingke Zhang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 296, P. 139631 - 139631

Published: Jan. 9, 2025

Language: Английский

Citations

3
Curcumin: A Potential Detoxifier Against Chemical and Natural Toxicants DOI Open Access
Harsh Kumar, Rajni Dhalaria, Neetika Kimta

et al.

Phytotherapy Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

ABSTRACT The human body gets exposed to a variety of toxins intentionally or unintentionally on regular basis from sources such as air, water, food, and soil. Certain can be synthetic, while some are biological. affect the various parts by activating numerous pro‐inflammatory markers, like oxidative stresses, that tend disturb normal function organs ultimately. Nowadays, people use different types herbal treatments, viz., drinks contain spices for detoxification their bodies. One example is turmeric, most commonly available spice in kitchen used across all kinds households. Turmeric contains curcumin, which natural polyphenol. Curcumin medicinal compound with biological activities, antioxidant, antineoplastic, anti‐inflammatory, antibacterial. Hence, this review gives comprehensive insight into promising potential curcumin heavy metals, carbon tetrachloride, drugs, alcohol, acrylamide, mycotoxins, nicotine, plastics. encompasses diverse animal‐based studies portraying curcumin's role nullifying toxic effects (especially liver, kidney, testicles, brain) enhancing defensive signaling pathways, improving antioxidant enzyme levels, inhibiting markers activities so on. Furthermore, also argues over safety assessment its utilization detoxifying agent.

Language: Английский

Citations

0
Effects of Lactic Acid and Glyceryl Lactate on Growth Performance, Antioxidant Capacity, and Intestinal Health of Piglets DOI Creative Commons
S. Guo,

Huiling Chu,

Bosen Peng

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(4), P. 391 - 391

Published: March 26, 2025

The aim of this study was to evaluate the effects lactic acid and glyceryl lactate on growth performance, antioxidant capacity, intestinal health in piglets. This included 240 castrated male piglets (initial body weight: 7.50 ± 0.54 kg) assigned four groups: CON (basal diet), LA diet + 0.5% acid), GL lactate), LG lactate). Each group had six replicates 10 trial lasted 28 days. Compared with control group, groups showed enhanced performance reduced diarrhea rate decreased chyme pH increased digestive enzyme activities. Moreover, displayed elevated jejunal mRNA levels tight junction protein occludin mucin MUC2, expression Nrf2 signaling pathway genes, activities enzymes GPX CAT, MDA content. Acidifier supplementation also modulated cecal bacterial abundance short-chain fatty (SCFA) Genera such as Faecalibaculum, Nocardiopsis, Collinsella, CAG269, Allobaculum, Enterococcus were affected. In conclusion, its combination improved piglet by enhancing barrier function, microbial community structure, SCFA production.

Language: Английский

Citations

0
Zearalenone causes ovarian damage and abnormal estradiol secretion in meat rabbits by inducing oxidative stress and inflammatory responses DOI Creative Commons
Fengyang Wu, Fengxia Wang,

Zhaohong Tang

et al.

Frontiers in Veterinary Science, Journal Year: 2025, Volume and Issue: 12

Published: April 10, 2025

Zearalenone (ZEA), a prevalent mycotoxin in animal feeds, is known to disrupt normal ovarian development and function due its estrogenic activity. This study investigates the toxic effects of ZEA on ovaries meat rabbits explores underlying mechanisms. Ninety healthy 41-day-old Hyla male were randomly assigned into three groups. The control group received basal diet, while experimental groups fed diets supplemented with 300 600 μg/kg ZEA, respectively. Each consisted 30 replicates, one rabbit per replicate, period lasted 42 days. results showed that, compared group, index was significantly increased supplementation ( p < 0.05). In addition, tissue exhibited pathological changes, including follicular dilatation, thinning granulosa, punctate necrosis granulosa cells, deep stained cytosolic nuclei, nuclear fragmentation. Compared elevated blood levels gonadotropin-releasing hormone, luteinizing estradiol, malondialdehyde (MDA), interleukin 1β (IL-1β) Conversely, total antioxidant power (TAOC) glutathione peroxidase (GSH-Px) activities reduced this level MDA GSH-Px TAOC Moreover, expression hormone receptor mRNA, heat shock protein 70 tumor factor-α IL-1β mRNA increased, whereas copper zinc superoxide dismutase decreased conclusion, induces oxidative stress inflammatory responses by modulating related genes. These development, cause impair secretion reproductive hormones. first report provides preliminary insights

Language: Английский

Citations

0
Curcumin-Loaded Silver-Based Metal–Organic Frameworks: Efficient Antibacterial and Antioxidant Properties against Escherichia coli and Staphylococcus aureus for Promoting Infected Wound Healing DOI

Jinyan Du,

Jiwei Hou,

S.M. Liu

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 8, 2025

Slow or noticeably delayed wound healing is frequently intimately linked to bacterial infection and excessive reactive oxygen species (ROS), while the inappropriate usage of antibiotics fuels rise resistance. The innovative materials are desperately needed eliminate bacteria effectively accelerate healing. In this work, a curcumin-loaded silver-based metal-organic framework (Cur/Ag-MOF) composite nanomaterial was developed, which exhibited good antimicrobial activity, biocompatibility, drug Meanwhile, surface-loaded curcumin can excess free radicals promote due its antioxidative ROS scavenging properties. Additionally, it discovered that application Cur/Ag-MOF site skin trauma significantly sped up process closure in mice used as subjects. These findings highlighted great potential for treating infection-induced injuries aiding reconstruction tissues.

Language: Английский

Citations

0
Curcumin Attenuates Fumonisin B1-Induced Cell Apoptosis by Upregulating Mir-1249 Expression to Inhibit the Ire1/Mkk7/Jnk/Caspase3 DOI
Jia Chen,

yiting liao,

yuhang yang

et al.

Published: Jan. 1, 2024

Fumonisin B1 (FB1) is a toxic metabolite produced by fungi of the Fusarium genus. FB1 common contaminant grains and their derived feed products, posing global concerns for environmental pollution food safety. Curcumin (Cur), natural polyphenolic compound, has anti-inflammatory, antioxidant, free radical scavenging properties. Although studies have explored apoptotic mechanisms FB1, underlying mitigation FB1-induced toxicity Cur are not fully understood, limiting its potential application as novel additive to prevent toxicity. In this study, porcine kidney cells (PK-15) were used experimental model, utilizing mRNA miRNA transcriptome technologies. The results revealed that upregulated miR-1249 inhibits target gene Ern1 in PK-15 cells, thereby suppressing IRE1/MKK7/JNK/CASPASE3 endoplasmic reticulum (ER) stress pathway alleviating cell apoptosis. Cell transfection experiments confirmed effectively attenuated apoptosis induced ER following with inhibitor. Similarly, mimic alleviated cells. findings indicate mitigates significantly reduces damage

Language: Английский

Citations

0
Rutin Alleviates Zearalenone-Induced Endoplasmic Reticulum Stress and Mitochondrial Pathway Apoptosis in Porcine Endometrial Stromal Cells by Promoting the Expression of Nrf2 DOI Creative Commons

Chuangjiang Chen,

Chenlong Wang, Hui Jiang

et al.

Toxins, Journal Year: 2024, Volume and Issue: 17(1), P. 7 - 7

Published: Dec. 26, 2024

Zearalenone (ZEA) is a mycotoxin commonly found in moldy cereals and has range of toxic effects that have seriously affected animal husbandry. Rutin, natural flavonoid with antioxidant activities, been studied for its potential involvement mitigating ZEA-induced apoptosis porcine endometrial stromal cells (ESCs) molecular mechanism, particularly concerning the expression Nrf2. This study investigates pathways by which rutin alleviates ESC apoptosis, focusing on role Experimental data reveal ZEA suppresses Nrf2 nuclear translocation reduces mitochondrial membrane (MMP), leading to oxidative stress, endoplasmic reticulum stress (ERS), pathway-driven apoptosis. Notably, mitigates through activation. These findings highlight as critical factor rutin's protective against offering valuable insights clinical prevention treatment toxicity.

Language: Английский

Citations

0