International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
26(1), P. 215 - 215
Published: Dec. 30, 2024
In
recent
years,
awareness
regarding
micro-nanoplastics’
(MNPs)
potential
effects
on
human
health
has
progressively
increased.
Despite
a
large
body
of
evidence
the
origin
and
distribution
MNPs
in
environment,
their
impact
remains
to
be
determined.
this
context,
there
is
major
need
address
carcinogenic
risks,
since
could
hypothetically
mediate
direct
indirect
effects,
latter
mediated
by
particle-linked
chemical
carcinogens.
Currently,
field
scarce
heterogeneous,
but
reported
increased
incidence
malignant
tumors
among
younger
populations,
together
with
ubiquitous
environmental
abundance
MNPs,
are
rising
global
concern
possible
role
development
progression
cancer.
review,
we
provide
an
overview
currently
available
eco-toxicology,
as
well
methods
for
identification
characterization
MNP
particulates
health-associated
focus
addition,
suggest
routes
future
research
order
unravel
carcinogenetic
exposure
understand
prognostic
preventive
implications
intratumoral
MNPs.
Ecotoxicology and Environmental Safety,
Journal Year:
2025,
Volume and Issue:
291, P. 117828 - 117828
Published: Feb. 1, 2025
Microplastics
pollution
has
raised
a
considerable
awareness
due
to
their
extensive
distribution
in
the
environment.
It
potential
side
effects
on
human
health.
can
enter
respiratory
system,
then
deposit
lung,
destroying
structure
of
bronchus
and
alveoli,
causing
pulmonary
inflammation,
mucus
production,
airway
hyperresponsiveness,
leading
aggravation
asthma.
Nevertheless,
underlying
mechanism
remains
elusive.
There
are
several
cytokines
involved
inflammatory
response
Heat
shock
protein
90α(HSP90α)
is
one
involving
inflammation
which
member
HSPs
family.
The
aim
this
study
explore
by
microplastics
influence
secretion
HSP90α
progression
Initially,
we
found
that
were
destroyed
epithelial
barrier,
resulting
inherent
dysfunction
HSP90α.
Then,
proved
activate
PI3K-Akt-mTOR
pathway
prompting
cells
secrete
proliferation
smooth
muscle
cells(ASMCs),
narrowing
hypersensitivity.
1G6-D7
monoclonal
antibody
HSP90,
reverse
infiltration,
hyperresponsiveness(AHR).
Overall,
these
finding
suggested
elicited
via
signaling
stimulated
ASMCs.
Hence,
present
unveils
novel
responsible
for
microplastic-induced
hyperreactivity,
establishing
basis
further
research
risk
evaluations
microplastics.
Inhalation Toxicology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 17
Published: Feb. 11, 2025
In
the
past
decade,
microplastics
(MPs)
have
drawn
significant
attention
as
widespread
environmental
contaminants,
with
research
increasingly
highlighting
their
harmful
effects
on
respiratory
health
in
aquatic
and
terrestrial
organisms.
Findings
revealed
human
lung
tissues,
raising
concerns
about
potential
role
damaging
tissue
integrity
contributing
to
pulmonary
fibrosis-a
chronic
inflammatory
condition
characterized
by
scarring
of
epithelial
tissues
due
accumulated
extracellular
matrix,
triggered
factors
such
alcohol,
pathogens,
genetic
mutations,
pollutants.
this
review,
we
explore
both
well-studied
lesser-studied
mechanisms
signaling
pathways,
aiming
shed
light
how
might
act
mediators
that
activate
distinct,
often
overlooked
cascades.
This
review
searched
PubMed
Google
Scholar
using
keywords
like
"plastic,"
"microplastic,"
"lung
fibrosis,"
"pulmonary
system,"
"exposure
route,"
"signaling
pathways,"
combined
"OR"
"AND"
singular
plural
forms.
These
pathways
could
not
only
induce
damage
but
also
play
a
development
fibrosis.
be
targeted
reduce
microplastic-induced
fibrosis,
opening
new
avenues
for
future
treatments.
Oncology Letters,
Journal Year:
2025,
Volume and Issue:
29(4), P. 1 - 14
Published: Feb. 21, 2025
Microplastics
(MPs)
are
pervasive
in
several
ecosystems
and
have
the
potential
to
infiltrate
multiple
aspects
of
human
life
through
ingestion,
inhalation
dermal
exposure,
thus
eliciting
substantial
concerns
regarding
their
implications
for
health.
Whilst
initial
research
has
documented
effects
MPs
on
disease
development
across
physiological
systems,
may
also
facilitate
tumor
progression
by
influencing
microenvironment
(TME).
This
evolving
focus
underscores
growing
interest
role
tumorigenesis
interactions
within
TME.
In
present
review,
relationship
between
TME
is
comprehensively
assessed,
providing
a
detailed
analysis
with
cells,
stromal
cells
(including
macrophages,
fibroblasts
endothelial
cells),
extracellular
matrix
inflammatory
processes.
Recommendations
future
directions
strategies
address
reduce
microplastic
pollution
proposed.
Frontiers in Medicine,
Journal Year:
2025,
Volume and Issue:
12
Published: Feb. 24, 2025
Respiratory
diseases
rank
among
the
foremost
causes
of
mortality
and
disability
globally,
with
long-term
exposure
to
environmental
pollutants
playing
a
critical
role
in
their
onset
progression.
Despite
this,
underlying
mechanisms
effective
targeted
treatments
for
these
disorders
remain
poorly
understood,
highlighting
an
urgent
need
focused
research.
Cell
death,
programmed
cellular
response
external
harmful
stimuli,
including
ferroptosis-a
recently
identified
form
iron-dependent
cell
death-emerges
as
pivotal
process.
Characterized
by
intracellular
iron
accumulation
lipid
peroxidation,
ferroptosis
appears
intricately
linked
lung
injury
induced
pollutants.
This
review
examines
triggered
factors,
aiming
shed
light
on
its
specific
pathophysiological
potential
therapeutic
target.
By
deepening
our
understanding
interactions
between
pollution,
ferroptosis,
damage,
we
hope
inform
strategies
intervention.
Life,
Journal Year:
2025,
Volume and Issue:
15(3), P. 392 - 392
Published: March 3, 2025
Micro-
and
nano-plastics
(MNPs)
are
small
plastic
particles
that
result
from
the
breakdown
of
larger
plastics.
They
widely
dispersed
in
environment
pose
a
threat
to
wildlife
humans.
MNPs
present
almost
all
everyday
items,
including
food,
drinks,
household
products.
Air
inhalation
can
also
lead
exposure
MNPs.
Research
animals
indicates
once
absorbed,
they
spread
various
organs,
liver,
spleen,
heart,
lungs,
thymus,
reproductive
kidneys,
even
brain
by
crossing
blood–brain
barrier.
Furthermore,
MPs
transport
persistent
organic
pollutants
or
heavy
metals
invertebrates
higher
levels
food
chain.
When
ingested,
additives
monomers
comprise
disrupt
essential
biological
processes
human
body,
thereby
leading
disturbances
endocrine
immune
systems.
During
2019
coronavirus
(COVID-19)
pandemic,
there
was
significant
increase
global
use
polypropylene-based
face
masks,
insufficient
waste
management
exacerbating
pollution.
This
review
examines
existing
research
on
impact
MNP
lung
kidney
health
based
vitro
vivo
studies.
Over
past
decades,
wide
range
studies
suggest
both
tissues
under
healthy
diseased
conditions.
Therefore,
this
emphasizes
need
for
additional
employing
multi-approach
analyses
associated
biomarkers
mechanisms
gain
comprehensive
precise
understanding
health.
