Toxic and essential metals: metabolic interactions with the gut microbiota and health implications

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: July 29, 2024

Human exposure to heavy metals, which encompasses both essential and toxic varieties, is widespread. The intestine functions as a critical organ for absorption metabolism of metals. Gut microbiota plays crucial role in metal absorption, metabolism, related processes. Toxic metals (THMs), such arsenic (As), mercury (Hg), lead (Pb), cadmium (Cd), can cause damage multiple organs even at low levels exposure, it emphasize their potential high toxicity. Nevertheless, certain trace elements, including iron (Fe), copper (Cu), manganese (Mn), play vital roles the biochemical physiological organisms concentrations but exert effects on gut higher levels. Some potentially micronutrients, chromium (Cr), silicon (Si), nickel (Ni), were considered be intermediate terms essentiality toxicity, had different metabolites. Bidirectional relationships between have been found. Heavy disrupts influences its functions, contributing metabolic other disorders. Furthermore, by serving physical barrier against modulating pH, oxidative balance, detoxification enzymes or proteins involved metabolism. interactions might positive negative according valence states, concentrations, forms same metal. This paper reviews 10 common with health implications. collated information could provide novel insights into disruption intestinal caused factor human diseases.

Language: Английский

Impacts of elevated lead levels on oxidative stress, hemodynamic, and biochemical indicators in goats

Italian Journal of Animal Science, Journal Year: 2025, Volume and Issue: 24(1), P. 813 - 826

Published: March 18, 2025

Language: Английский

Dietary Fiber Intake Improves Osteoporosis Caused by Chronic Lead Exposure by Restoring the Gut–Bone Axis

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1513 - 1513

Published: April 29, 2025

Background: Lead (Pb), a pervasive environmental toxicant with specific toxicity to bone, has been recognized as significant etiological factor in the pathogenesis of osteoporosis. While dietary fiber (DF) demonstrates anti-osteoporotic potential, its protective role against Pb-induced bone loss remains unexplored. Methods: This study analyzed association between fiber, blood lead, and osteoporosis based on NHANES database, validated it by constructing lead exposed mouse model. Micro CT was used evaluate microstructure, ELISA detect markers, q-PCR/Western blot measure intestinal tight junction protein, flow cytometry analyze Treg cells colon/bone tissue, GC-MS short chain fatty acids, 16S rRNA sequencing changes gut microbiota. The regulatory mechanism metabolism barrier mice systematically evaluated. Results: Based data analysis, found that can reduce risk populations. Animal experiments have shown intervention significantly increases density, improves microstructure metabolic indicators, repairs damage caused exposure, regulates immune balance mice. At same time, promotes generation acids proliferation beneficial Conclusions: These findings indicate DF mitigates through restoration, SCFA-mediated immunomodulation, microbiota-driven cell expansion along gut–bone axis.

Language: Английский