Spectroscopy, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 19, 2024
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1734 - 1734
Published: Feb. 18, 2025
The human body is known as a responsive healing machine, but sometimes, broken bones do not heal, especially if bacterial infection present. present study describes the fabrication and characterization of nanocomposite hydrogel patch incorporated with silicon nitride magnesium oxide (MgO) deposited on halloysite nanotube (HNT) surface using facile inexpensive electrodeposition coating process. Scanning electron microscopy (SEM) was used to observe morphology MgO/HNT patch. Material characterization, including SEM, contact angle, pore size analysis, tensile properties, performed determine composite's structure material properties. E. coli S. aureus cultures were test antimicrobial Cellular response MgO/HNTs studied mouse embryonic fibroblasts. discovered possess inherent properties when tested against cultures, it found enhance fibroblast cell migration proliferation. also showed sustained drug release. Materials involved in helped swelling by which has approximately 400% its initial weight during test.
Language: Английский
Citations
1
International Journal of Biological Sciences, Journal Year: 2024, Volume and Issue: 20(14), P. 5779 - 5792
Published: Oct. 21, 2024
The escalation of plastic pollution represents a global environmental and health problem. Important toxic effects have been attributed to the increasing diffusion microplastics (MPs) nanoplastics (NPs) derived from degradation plastics. These particles ubiquitously observed in environment, with humans being continuously exposed via ingestion, inhalation skin contact. Nonetheless, cellular homeostasis imbalance induced by micro- nano- plastics (MNPs) human has only recently shown, while most evidence molecular mechanisms studies
Language: Английский
Citations
5
Applied Sciences, Journal Year: 2024, Volume and Issue: 14(16), P. 7280 - 7280
Published: Aug. 19, 2024
Nanoplastics (NPs) represent an escalating hazard to both humans and the ecosystem due their pervasive presence. This review delves into (i) widespread occurrence of NPs across different environmental matrices, including food; (ii) routes estimates for human exposure; (iii) mechanisms blood–brain barrier (BBB) crossing; (iv) implications health, with a specific focus on molecular features associated neurotoxicity neurodegenerative processes. The impact central nervous system, ability cross BBB underpinning mechanisms, potential initiate by fostering β-amyloid aggregation, interactions metallo-enzymes (such as superoxide dismutase) are elucidated. analysis transcriptomics epigenomic results, microRNA dysregulation, unveil how could contribute neurological disorders. need considering overlaps among diverse pathogenetic when probing effects is discussed. Additional urgent needs development reliable in vitro models studies able mimic complexity system exposure such more environmentally relevant NPs. Finally, extremely sensitive detection methodologies quantify biological matrices pressing priority.
Language: Английский
Citations
3
Mundo Nano Revista Interdisciplinaria en Nanociencia y Nanotecnología, Journal Year: 2024, Volume and Issue: 18(34), P. 1e - 26e
Published: Sept. 20, 2024
Los microplásticos y nanoplásticos representan una amenaza para la salud humana el medio ambiente. Estos fragmentos a escala nanométrica micrométrica provienen de diversas fuentes generación, todas ellas resultado actividades humanas productos fabricados por hombre. Las repercusiones ambiente son preocupantes debido su naturaleza química, estos presentan desafíos significativos detección eliminación poder actuar como vectores transferencia contaminantes químicos biológicos. En cuanto los métodos identificación eliminación, actualmente se exploran enfoques físicos, biotecnológicos. Sin embargo, aún necesita investigar profundidad, mejorar eficacia viabilidad estas técnicas en necesaria abordar problema. La gestión representa un desafío multifacético, cual requiere acción coordinada mitigar sus impactos negativos. presente revisión aborda daño potencial causado micro al equilibrio medioambiental, las fisicoquímicos posibles rutas eliminación.
Citations
3
Cells, Journal Year: 2025, Volume and Issue: 14(4), P. 241 - 241
Published: Feb. 7, 2025
Brain ischemia, a condition in which the brain is deprived of blood flow, can lead to stroke due blocked or unstable vessels. Global cerebral ischemia (GCI), characterized by an interruption deprives oxygen and nutrients, producing reactive species (ROS) that trigger cell death, kills nerve cells. Microplastics (MPs), tiny environmental pollutants, enter human body through contaminated food, water, disposable items, cosmetics, more. Once brain, MPs increase neuroinflammation overstimulating inflammatory factors such as microglia. also damage neurons scratching myelin microtubules, slowing signal transduction, causing cognitive impairment, leading neuronal death. Furthermore, microtubule may result release phosphorylated tau proteins, potentially linked Alzheimer's disease. We hypothesized could exacerbate destruction after GCI, increased To test this hypothesis, we administered (0.5 µm) orally at dose 50 mg/kg before inducing GCI. Staining techniques Fluoro-Jade B (FJB), ionized calcium-binding adaptor molecule 1 (Iba-1), cluster differentiation 68 (CD68), basic protein (MBP), microtubule-associated 2 (MAP2) were used, along with Western blot analysis for interleukin-6 (IL-6), TNF-α, tau-5, phospho-tau (S396) evaluate effects on neuroinflammation, destruction. The results showed MP accumulation significantly disruption, death GCI-MP group compared GCI-vehicle group. Therefore, study suggests daily life contribute exacerbation disease, severe
Language: Английский
Citations
0
Toxics, Journal Year: 2025, Volume and Issue: 13(3), P. 224 - 224
Published: March 19, 2025
Micro(nano)plastics (MNPs) pose a significant threat to both ecological environments and human health. This review systematically examines the developmental toxicity of MNPs in mammals, with particular focus on impact maternal paternal exposure offspring. Evidence indicates that can cross placental barriers, inducing abnormal development embryos, fetuses, placentas. disruption leads range adverse outcomes, including neurodevelopmental abnormalities, behavioral disorders, reproductive system damage, etc., Through comprehensive analysis existing literature, this aims provide foundation for future research highlight urgent need action mitigate detrimental effects health ecosystem integrity.
Language: Английский
Citations
0
Spectroscopy, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 19, 2024
Language: Английский
Citations
0