Cosmetics,
Journal Year:
2024,
Volume and Issue:
11(6), P. 213 - 213
Published: Dec. 6, 2024
Given
the
pivotal
role
played
by
microbiome
in
skin
health,
it
is
important
to
understand
how
its
composition
varies
with
age,
sex,
and
body
site
regular
use
of
topical
products.
Four
studies
were
carried
out
determine
effects
long-term
(4-week)
different
dexpanthenol-containing
products
on
a
varied
population
cosmetically
dry
skin.
The
was
assessed
before
after
product
usage.
No
significant
changes
richness
or
diversity
found
for
individual
test
products;
however,
meta-analysis
combined
dataset
did
show
as
function
subject’s
site.
work
presented
here
demonstrates
carefully
formulated
skin,
when
used
way
that
representative
real-life
usage
conditions,
can
respect
microbial
present
across
widely
study
population.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(10), P. 1256 - 1256
Published: Oct. 17, 2024
Environmental
pollution
continues
to
increase
with
industrial
development
and
has
become
a
threat
human
health.
Atmospheric
particulate
matter
(PM)
was
designated
as
Group
1
carcinogen
by
the
International
Agency
for
Research
on
Cancer
in
2013
is
an
emerging
global
environmental
risk
factor
that
major
cause
of
death
related
cardiovascular
respiratory
diseases.
PM
complex
composed
highly
reactive
organic
matter,
chemicals,
metal
components,
which
mainly
excessive
production
oxygen
species
(ROS)
can
lead
DNA
cell
damage,
endoplasmic
reticulum
stress,
inflammatory
responses,
atherosclerosis,
airway
remodeling,
contributing
increased
susceptibility
exacerbation
various
diseases
infections.
effects
health
depending
particle
size,
physical
chemical
characteristics,
source,
exposure
period.
smaller
than
5
μm
penetrate
accumulate
alveoli
circulatory
system,
causing
harmful
skin,
brain.
In
this
review,
we
describe
relationship
mechanism
ROS-mediated
oxidative
responses
caused
organs,
well
comprehensively
discuss
harmfulness
PM.
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
15
Published: Jan. 2, 2025
Total
glucosides
of
paeony
(TGP)
are
a
group
monoterpenes
extracted
from
Paeonia
lactiflora
Pall.
,
primarily
including
metabolites
such
as
paeoniflorin
and
oxypaeoniflorin.
Modern
pharmacological
studies
have
shown
that
TGP
possesses
variety
biological
effects,
immunomodulatory,
anti-inflammatory,
hepatoprotective,
nephroprotective,
antidepressant,
cell
proliferation
regulatory
activities.
In
recent
years,
clinical
research
has
demonstrated
favorable
therapeutic
effects
on
disorders
the
liver,
cardiovascular,
nervous,
endocrine,
skeletal
systems.
Particularly
in
dermatological
treatments,
been
found
to
significantly
improve
symptoms
shorten
course
disease.
However,
there
still
certain
limitations
scientific
rigor
existing
its
application.
To
assess
potential
treating
dermatologic
diseases,
this
article
provides
review
botanical
sources,
preparation
extraction
processes,
quality
control,
major
chemical
metabolites,
well
applications
dermatology.
Additionally,
mechanisms
action,
gaps,
future
directions
for
treatment
diseases
discussed,
offering
valuable
guidance
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(2), P. 438 - 438
Published: Jan. 7, 2025
Epigenetic
mechanisms
are
central
to
the
regulation
of
all
biological
processes.
This
manuscript
reviews
current
understanding
diverse
epigenetic
modifications
and
their
role
in
establishment
maintenance
normal
skin
functions.
In
healthy
skin,
these
allow
for
precise
control
gene
expression,
facilitating
dynamic
balance
between
cell
proliferation
differentiation
necessary
effective
barrier
function.
Furthermore,
as
ages,
alterations
marks
can
lead
impaired
regenerative
capacity
increased
susceptibility
environmental
stressors.
The
interaction
microbiota
will
also
be
explored,
highlighting
how
microbial
communities
influence
health
by
modulating
host
expression.
Future
research
should
focus
on
development
targeted
interventions
promote
development,
resilience,
longevity,
even
an
ever-changing
environment.
underscores
need
integrative
approaches
study
complex
regulatory
networks.
Marine Drugs,
Journal Year:
2025,
Volume and Issue:
23(3), P. 135 - 135
Published: March 20, 2025
Air
pollution-related
skin
damage
has
heightened
the
demand
for
natural
protective
agents.
Hizikia
fusiformis,
a
brown
seaweed
rich
in
fucoidan
and
bioactive
fatty
acids
(α-linolenic
acid,
eicosatetraenoic
palmitic
acid),
possesses
antioxidant
anti-inflammatory
properties.
This
study
investigated
effects
of
H.
fusiformis
ethanol
extract
(HFE)
against
particulate
matter
(PM)-induced
oxidative
stress,
inflammation,
apoptosis
human
keratinocytes.
Antioxidant
activity
was
assessed
using
DPPH
hydroxyl
radical
scavenging
assays,
while
PM-induced
cytotoxicity,
ROS
generation,
inflammatory
markers,
apoptotic
pathways
were
evaluated
WST-8
assay,
DCFH2-DA,
qPCR,
western
blotting,
Hoechst
staining.
HFE
significantly
reduced
levels,
enhanced
enzyme
activity,
mitigated
cytotoxicity.
These
mediated
by
acids,
which
modulated
(NF-κB
MAPK),
stabilized
membranes,
inhibited
(Bcl-2,
Bax,
caspase-3).
Collectively,
these
findings
highlight
HFE’s
potential
as
anti-pollution
skincare
ingredient,
supporting
further
vivo
studies
formulation
development.
Sustainability,
Journal Year:
2025,
Volume and Issue:
17(7), P. 3238 - 3238
Published: April 5, 2025
Urban
heat
island
(UHI)
effect
significantly
influences
the
urban
sustainability
and
health
of
cities
varies
seasonally.
However,
spring
autumn
have
received
less
attention.
Furthermore,
research
on
long-term
seasonal
UHI
changes
impacts
is
insufficient.
This
study
examines
spatiotemporal
dynamics
gradient
characteristics
in
spring,
summer,
autumn,
winter
Changsha,
a
typical
subtropical
“furnace
city”
from
2006
to
2022.
(1)
Spatiotemporal
dynamics:
The
high-temperature
(relatively
zone
zone)
range
expands
most
least
autumn.
Additionally,
migrates
northward
within
area,
proximity
core
results
multiple
effects.
(2)
Gradient
characteristics:
proportion
decreases
varying
degrees
5
km
central
point,
but
increases
6–8
11–13
gradients,
especially
8
aggregation
index
(AI),
contagion
(CONTAG),
largest
patch
(LPI)
decreased,
with
patches
more
affected
by
these
metrics
Overall,
this
offers
new
insights
into
effects
development
UHI,
which
are
crucial
for
addressing
climate
change,
promoting
sustainability,
improving
human
well-being.
Health Science Reports,
Journal Year:
2025,
Volume and Issue:
8(4)
Published: April 1, 2025
ABSTRACT
Background
and
Aims
Human
activities
have
greatly
influenced
global
temperatures,
leading
to
climate
change
warming.
This
narrative
review
aims
explore
the
relationship
between
immune
system,
focusing
on
how
environmental
stressors
can
affect
regulation,
both
hyperactivity
suppression.
Methods
A
comprehensive
search
was
conducted
in
PubMed
Google
Scholar
for
peer‐reviewed
studies
published
up
June
2024.
The
terms
included
“climate
change,”
“human
health,”
“infection,”
“immunity,”
“disease.”
Inclusion
criteria
were
based
relevance,
originality,
accessibility.
Results
Exposure
elevated
temperatures
significantly
impair
system
cells,
an
overproduction
of
signaling
molecules
that
promote
inflammation.
Temperature
fluctuations
been
shown
influence
various
aspects
adaptive
response,
including
cell
mobilization,
antigen
processing
presentation,
lymphocyte
trafficking
activation,
functionality
B
T
cells.
Notably,
some
research
suggests
heat
stress
negatively
impacts
differentiation,
replication,
proportion,
resulting
decreased
immunoglobulin
cytokine
production,
contributing
immunosuppression.
Additionally,
change‐related
exposures
compromise
epithelial
barriers
skin,
lungs,
gut,
microbial
dysbiosis,
dysregulation.
Furthermore,
factors
such
as
temperature
variations,
humidity,
air
pollutant
levels
may
exacerbate
prevalence
infectious
diseases,
measles
HIV,
with
varying
acute,
chronic,
latent
infections,
further
variability.
Conclusion
Climate
change,
particularly
increased
function,
heightened
inflammatory
responses,
Future
should
focus
developing
sustainable
management
strategies
enhance
health
resilience
face
ongoing
climatic
changes.
