Associations between phenol and paraben exposure and the risk of developing breast cancer in adult women: a cross-sectional study

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 3, 2025

Increasing evidence suggests that endocrine-disrupting chemicals (EDCs) have adverse effects on breast cancer (BC). The aim of this study was to assess the association between exposure prevalent EDCs—phenols and parabens—and risk developing BC. Data urinary bisphenol A (BPA), triclosan (TRS), benzophenone-3 (BP3), methyl paraben (MPB), ethyl (EPB), propyl (PPB), butyl (BUP) were obtained from 2005–2014 National Health Nutrition Examination Survey. total 4455 subjects included in cross-sectional study. results weighted multivariable regression models indicated elevated concentrations TRS increased BC by 2.33 (Q2: 95% CI = 1.45–3.75, p < 0.001) 1.94 times (Q3: 1.21–3.09, 0.006), respectively. nonlinear statistically significant (P 0.007), with restricted cubic splines (RCS) curve exhibiting an inverted U shape. more pronounced among overweight individuals (BMI ≥ 25 kg/m2), those aged 60 years, white individuals. Weighted quantile sum (WQS) Bayesian Kernel Machine Regression (BKMR) analysis revealed no overall mixtures phenol metabolites risk. However, most influential, higher (both continuous categorical) significantly associated risk, particularly

Language: Английский

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Association between Biological Aging and Cardiovascular Health: Combined Evidence based on Cross-sectional and Prospective Study

Archives of Gerontology and Geriatrics, Journal Year: 2025, Volume and Issue: 132, P. 105785 - 105785

Published: Feb. 15, 2025

Language: Английский

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The Mediating Role of Body Mass Index in the Association Between Dietary Index for Gut Microbiota and Biological Age: A Study Based on NHANES 2007–2018

Nutrients, Journal Year: 2024, Volume and Issue: 16(23), P. 4164 - 4164

Published: Nov. 30, 2024

The dietary index for gut microbiota (DI-GM) is a newly proposed metric assessing diet quality, and its relationship with biological age unclear. We hypothesize that consuming foods conducive to healthy environment may decelerate aging.

Language: Английский

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Associations of Exposure to 56 Serum Trace Elements with the Prevalence and Severity of Acute Myocardial Infarction: Omics, Mixture, and Mediation Analysis

Biological Trace Element Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Language: Английский

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Environmental exposure to perchlorate, nitrate, and thiocyanate in relation to biological aging in U.S. adults, a cross-sectional NHANES study

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: March 18, 2025

Few studies have investigated the associations between perchlorate, nitrate, and thiocyanate (PNT) biological aging. This study aimed to assess association PNT aging among U.S. adults. Utilizing multivariable linear regression restricted cubic splines (RCS), we analyzed urinary levels' impact on phenotypic age age. Subgroup sensitivity analyses were also conducted. Weighted Quantile Sum (WQS) Bayesian Kernel Machine Regression (BKMR) models examined mixtures. 8,368 participants analyzed. Mean was 43.05 ± 0.48 years, mean 47.08 0.4 years. Multivariable showed significant negative higher levels (perchlorate β = -0.6, 95% CI: -0.93 -0.27; nitrate -0.81, -1.19 -0.42; -0.56, -0.77 -0.34) after covariates adjusted. RCS demonstrated nonlinear relationships exposure (nonlinear p values: 0.002, <0.001, <0.001), with stable results in analyses. Nitrate a (β -0.78, -1.13 -0.44), indicating consistent relationship observed through remaining across WQS revealed mixture both positive directions, direction. BKMR analysis mixtures age, identified as primary predictors of No found Individual or combined are negatively associated High is reduced showcasing outcomes.

Language: Английский

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Irisin mitigates osteoporotic-associated bone loss and gut dysbiosis in ovariectomized mice by modulating microbiota, metabolites, and intestinal barrier integrity

BMC Musculoskeletal Disorders, Journal Year: 2025, Volume and Issue: 26(1)

Published: April 16, 2025

Language: Английский

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Associations between phthalate metabolites and two novel systemic inflammatory indexes: a cross-sectional analysis of NHANES data

Annals of Medicine, Journal Year: 2025, Volume and Issue: 57(1)

Published: April 24, 2025

The potentially risky effects of metabolites phthalates (mPAEs) on inflammation and immune function have attracted much attention in recent years. However, direct studies the relationship between these systemic inflammatory index (SII) response (SIRI) are limited. This cross-sectional study used generalized linear regression models (GLM), restricted cubic splines (RCS), weighted quantile sum (WQS), Bayesian kernel-machine (BKMR) to analyze data from 2,763 U.S. adults aged 20 80 years, obtained National Health Nutrition Examination Survey (NHANES) conducted 2013 2018. aimed investigate urine samples nine mPAEs levels SII/SIRI a single, nonlinear, mixed explored robustness findings under single using two sensitivity analyses for completeness. In addition, six variables (age, sex, BMI, percentage total daily energy intake ultra-processed foods (UPFs), vegetable intake, dietary supplements) association results were through subgroup identify important confounders. exposure analyses, mono-n-butyl phthalate (MnBP), mono-ethyl (MEP), monobenzyl (MBzP) positively associated with SII/SIRI. demonstrated positive collective concentrations SII/SIRI, MBzP being identified as significant contributor urinary mPAEs. analysis exposures show that is more females, overweight/obese populations, young/middle-aged populations high UPFs. Positive associations was determined most impact. significantly influenced by female groups, young middle-aged overweight obese individuals, well those higher

Language: Английский

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Assessing the toxicological effects and mechanism of plasticizer exposure on inflammatory bowel disease based on network toxicology and molecular docking

Food and Chemical Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 115543 - 115543

Published: May 1, 2025

Language: Английский

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Association of serum 25(OH)D3 and cognitive levels with biological aging in the elderly: a cross-sectional study

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: May 12, 2025

Background Biological aging, a fundamental process affecting health and longevity, is pivotal to understanding the physiological decline associated with aging. Serum vitamin D3 deficiency cognitive impairment are common issues among older adults. However, joint associations of serum D levels biological aging remain poorly understood. This study aims evaluate independent combined in Methods cross-sectional included adults aged 60 years from 2011–2014 National Health Nutrition Examination Survey (NHANES). was measured using Phenotypic Age calculated biomarkers. Cognitive performance assessed Centre for Establishment Registry Alzheimer’s Disease (CERAD) test, Animal Fluency test (AFT), Digit Symbol Substitution (DSST). Multivariable regression restricted cubic spline models were used examine relationships between 25(OH)D3 levels, performance, Results After adjusting all covariates, individuals highest quartile had reduced risk compared those lowest (CERAD: OR 0.91; 95% CI, 0.57–1.46; AFT: 0.48; 0.29–0.82; DSST: 0.43; 0.24–0.77). A U-shaped relationship observed Combined analyses revealed that both low across tests 1.43; 1.02–1.98; 1.70; 1.24–2.32; 1.67; 1.22–2.27). Notably, DSST, normal showed reduction by 2.40 ( p &lt; 0.01). Conclusion In adults, strongly an increased

Language: Английский

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Association of biological aging and the prevalence of nonalcoholic fatty liver disease: a population-based study

BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 13, 2025

To examine the relationship between biological aging and prevalence of NAFLD. We used recommended sampling weights to account for complex survey design NHANES. The analysis, utilizing data from 2005 2016, aimed investigate impact on NAFLD using various statistical methods. A restricted cubic spline (RCS) model was applied explore dose-response relationship, while logistic regression examined linear associations. robustness association across different subgroups also tested. study included 2786 participants. found significant associations following metrics: AL score (OR (95%CI) = 1.1932 (1.0597 ~ 1.3435), P 0.0035), HD 1.2092 (1.0565 1.3839), 0.0058), PA 1.7564 (1.1949 2.5818), 0.0042). All metrics were identified as independent predictors. most associated with persisted subgroups. aging, emphasizing importance addressing potential health risks related aging.

Language: Английский

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