Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1528 - 1528

Published: Dec. 13, 2024

Aflatoxins (AFTs) are a form of mycotoxins mainly produced by Aspergillus flavus and parasiticus, which common contaminants in various agricultural sources such as feed, milk, food, grain crops. Aflatoxin B1 (AFB1) is the most toxic one among all AFTs. AFB1 undergoes bioactivation into AFB1-8,9-epoxide, then leads to diverse harmful effects neurotoxicity, carcinogenicity, hepatotoxicity, reproductive toxicity, nephrotoxicity, immunotoxicity, with specific molecular mechanisms varying different pathologies. The detoxification great importance for safeguarding health animals humans has increasingly attracted global attention. Recent research shown that melatonin supplementation can effectively mitigate AFB1-induced multiple effects. protection involve inhibition oxidative stress, upregulation antioxidant enzyme activity, reduction mitochondrial dysfunction, inactivation apoptotic pathway, blockade inflammatory responses, attenuation cytochrome P450 enzymes’ expression activities. In summary, this review sheds new light on potential role detoxifying agent against AFB1. Further exploration precise clinical efficacy promising treatment urgently needed.

Language: Английский