Effect of Fluoride on Gut Microbiota: A Systematic Review DOI Creative Commons
Momina Yasin, Fatemeh Vida Zohoori, Elizabeth Adjoa Kumah

et al.

Nutrition Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

Fluoride can prevent dental caries by inhibiting demineralization and promoting remineralization of teeth while affecting the physiology oral microbiota, thus cellular enzymes. However, effect systemic fluoride on gut microbiota is unknown. To explore impacts composition abundance associated functions such as gene metabolic regulation. A systematic database search was conducted MEDLINE, Web Science, Scopus, PubMed, CINAHL, Embase to find articles studies reporting effects microbiota. Forty-nine were included (n = 42 in animals, 4 humans, 3 vitro studies) after screening for title, abstract, full text using Covidence check against eligibility criteria. Data extracted study quality assessed Mixed Method Appraisal Tool 2 reviewers independently. Two human fluorosis 1 patients with breast cancer (intestinal fluorine-18 fluorodeoxyglucose uptake) showed significant differences microbial composition, increased relative Acidobacteria Proteobacteria, decreased Firmicutes Bacteroidetes. An ex vivo feces indicated that ≤ mg L-1 NaF might boost "health-associated" taxa, but concentrations (≥ 10 NaF) could increase ratio some unhealthy microbes 24 hours. The animal examined high doses water diet (50-1200 long-term (1-6 months) short-term (6 hours 7 days) exposure, all showing a disturbance Bacteroidota ratio. In potentially may be detrimental microbiome, whereas had positive effects. Similarly, ≥ 50 unsafe, 25 harmless PROSPERO registration No. CRD42022347357.

Language: Английский

Gut microbiota in health and disease: advances and future prospects DOI Creative Commons
Y J Zhang, Hong Wang, Yingpeng Sang

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(12)

Published: Nov. 20, 2024

Abstract The gut microbiota plays a critical role in maintaining human health, influencing wide range of physiological processes, including immune regulation, metabolism, and neurological function. Recent studies have shown that imbalances composition can contribute to the onset progression various diseases, such as metabolic disorders (e.g., obesity diabetes) neurodegenerative conditions Alzheimer's Parkinson's). These are often accompanied by chronic inflammation dysregulated responses, which closely linked specific forms cell death, pyroptosis ferroptosis. Pathogenic bacteria trigger these death pathways through toxin release, while probiotics been found mitigate effects modulating responses. Despite insights, precise mechanisms influences diseases remain insufficiently understood. This review consolidates recent findings on impact immune‐mediated inflammation‐associated conditions. It also identifies gaps current research explores potential advanced technologies, organ‐on‐chip models microbiome–gut–organ axis, for deepening our understanding. Emerging tools, single‐bacterium omics spatial metabolomics, discussed their promise elucidating microbiota's disease development.

Language: Английский

Citations

8
The NRF2/HO- 1 Pathway: a Potential Regulatory Factor in Fluoride-Induced Colonic Injury under Estrogen Deficiency DOI
Meng Gao, Sai Zhang, Jing Zhao

et al.

Biological Trace Element Research, Journal Year: 2025, Volume and Issue: unknown

Published: May 3, 2025

Language: Английский

Citations

0
Effect of Fluoride on Gut Microbiota: A Systematic Review DOI Creative Commons
Momina Yasin, Fatemeh Vida Zohoori, Elizabeth Adjoa Kumah

et al.

Nutrition Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

Fluoride can prevent dental caries by inhibiting demineralization and promoting remineralization of teeth while affecting the physiology oral microbiota, thus cellular enzymes. However, effect systemic fluoride on gut microbiota is unknown. To explore impacts composition abundance associated functions such as gene metabolic regulation. A systematic database search was conducted MEDLINE, Web Science, Scopus, PubMed, CINAHL, Embase to find articles studies reporting effects microbiota. Forty-nine were included (n = 42 in animals, 4 humans, 3 vitro studies) after screening for title, abstract, full text using Covidence check against eligibility criteria. Data extracted study quality assessed Mixed Method Appraisal Tool 2 reviewers independently. Two human fluorosis 1 patients with breast cancer (intestinal fluorine-18 fluorodeoxyglucose uptake) showed significant differences microbial composition, increased relative Acidobacteria Proteobacteria, decreased Firmicutes Bacteroidetes. An ex vivo feces indicated that ≤ mg L-1 NaF might boost "health-associated" taxa, but concentrations (≥ 10 NaF) could increase ratio some unhealthy microbes 24 hours. The animal examined high doses water diet (50-1200 long-term (1-6 months) short-term (6 hours 7 days) exposure, all showing a disturbance Bacteroidota ratio. In potentially may be detrimental microbiome, whereas had positive effects. Similarly, ≥ 50 unsafe, 25 harmless PROSPERO registration No. CRD42022347357.

Language: Английский

Citations

0