Placental Ferroptosis May Be Involved in Prenatal Arsenic Exposure Induced Cognitive Impairment in Offspring

Biological Trace Element Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Language: Английский

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Astaxanthin Inhibits Ferroptosis of Hippocampal Neurons in Kainic Acid‐Induced Epileptic Mice by Activating the Nrf2/GPX4 Signaling Pathway

CNS Neuroscience & Therapeutics, Journal Year: 2025, Volume and Issue: 31(2)

Published: Feb. 1, 2025

ABSTRACT Background Epilepsy, a prevalent neurological disorder, is distinguished by episodic abnormal discharges of neurons within the brain, resulting in transient brain dysfunction. Prior research has identified novel form cell death termed ferroptosis, which intricately linked to initiation and progression epilepsy. It been demonstrated that astaxanthin (AST) can inhibit ferroptosis enhancing activity nuclear factor erythroid 2‐related 2 (Nrf2), thereby providing cytoprotection. Therefore, this study aims investigate whether AST alleviate neuronal epilepsy activating Nrf2/GPX4 pathway, exerting neuroprotective effect. Methods By constructing kainic acid (KA)‐induced mouse model KA‐induced HT22 model, we employed behavioral testing, Western blot analysis, quantitative real‐time reverse transcription qRT‐PCR, ferroptosis‐related assay kits, immunofluorescence staining, other methods. These methodologies were utilized protective effects underlying mechanisms on epileptic mice neurons. Results Our results demonstrate pretreatment alleviates behaviors cognitive impairments mitigates indicators such as lipid peroxidation mitochondrial morphological alterations. This effect appears be mediated activation signaling axis. In vitro studies further revealed confers neuroprotection against death, an abrogated Nrf2 inhibitor. Hence, properties are significantly associated with modulation Nrf2‐mediated corroborated bioinformatics analyses. Conclusion The effectively inhibits both vivo models via pathway. finding suggests holds promise potential therapeutic agent for treatment

Language: Английский

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The Keap1/Nrf2/ARE/HO-1 axis in epilepsy: Crosstalk between oxidative stress and neuroinflammation

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 153, P. 114304 - 114304

Published: March 20, 2025

Language: Английский

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Regulation Progression on Ellagic Acid Improving Poultry Production Performance by Regulating Redox Homeostasis, Inflammatory Response, and Cell Apoptosis

Animals, Journal Year: 2024, Volume and Issue: 14(20), P. 3009 - 3009

Published: Oct. 17, 2024

It has been approximately 2000 years since the medicinal homologous theory, which primarily holds that food same therapeutic value as medicine in order to improve health of both humans and animals. In recent years, this theory also proposed be used poultry breeding. Ellagic acid (EA), a natural compound extracted from foods such raspberries pomegranates, is reported have incomparable advantages improving production performance disease resistance due its pharmacological properties, regulate processes redox homeostasis, inflammatory response, cell apoptotic death. However, application research EA are still initial stage, potential mechanisms biological functions affecting animal not clearly identified, requires more attention worldwide. This mini-review collects latest 10-year achievements on effects health, aiming promote practical maintaining formulating corresponding targeted strategies.

Language: Английский

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Arsenic contamination in rice and drinking water: An insight on human cognitive function

Journal of Hazardous Materials Advances, Journal Year: 2024, Volume and Issue: unknown, P. 100543 - 100543

Published: Nov. 1, 2024

Language: Английский

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