The dual roles of human PYHIN family proteins in cancer: mechanisms and therapeutic implications DOI Creative Commons
Shuyan Zeng, Zhiyong Zhou, Yi Li

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 2, 2025

The human PYHIN family proteins, including AIM2, IFI16, IFIX, and MNDA, which are crucial cytosolic nucleic acid sensors. These proteins share a common structural feature, signature N-terminal PYD domain C-terminal HIN-200 domain, enable them to recognize intracellular acids assemble inflammasomes, triggering inflammatory responses programmed cell death. Over the last decade, it has emerged that play multifaceted roles in cancer biology, with dualistic due tumor heterogeneity microenvironment’s plasticity through dependent or independent of inflammasome mechanisms. Here, we discuss their ability function as both suppressor promoter progression emphasizes need for further research delineate precise mechanisms by these operate various contexts. Understanding dynamics could pave way novel therapeutic approaches harness dual nature members improve treatment outcomes.

Language: Английский

The dual roles of human PYHIN family proteins in cancer: mechanisms and therapeutic implications DOI Creative Commons
Shuyan Zeng, Zhiyong Zhou, Yi Li

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 2, 2025

The human PYHIN family proteins, including AIM2, IFI16, IFIX, and MNDA, which are crucial cytosolic nucleic acid sensors. These proteins share a common structural feature, signature N-terminal PYD domain C-terminal HIN-200 domain, enable them to recognize intracellular acids assemble inflammasomes, triggering inflammatory responses programmed cell death. Over the last decade, it has emerged that play multifaceted roles in cancer biology, with dualistic due tumor heterogeneity microenvironment’s plasticity through dependent or independent of inflammasome mechanisms. Here, we discuss their ability function as both suppressor promoter progression emphasizes need for further research delineate precise mechanisms by these operate various contexts. Understanding dynamics could pave way novel therapeutic approaches harness dual nature members improve treatment outcomes.

Language: Английский

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