American Journal of Industrial Medicine, Journal Year: 2025, Volume and Issue: unknown
Published: May 8, 2025
ABSTRACT Objectives Nonalcoholic fatty liver disease (NAFLD) is a major public health problem and the most common chronic today. In Korea, prevalence incidence of NAFLD are currently very high, causing serious social burden. Perfluoroalkyl substances (PFAS) have been consistently implicated as potential cause NAFLD, but research in Koreans limited. Methods Using data from 4th Korean National Environmental Health Survey (KoNEHS, n = 2859), we investigated association between PFAS blood levels NAFLD. Multivariable logistic regression models were used to calculate odds ratios (ORs) for effects PFAS. A mediation analysis was also conducted examine mediating effect obesity. Finally, weighted quantile sum (WQS) G‐computation methods implemented evaluate joint mixtures. Hepatic steatosis index diagnostic tool Results Through multivariable regression, statistically significant associations with observed perfluorooctanoic acid (PFOA) (OR 1.09–1.39), perfluorooctansulfonate (PFOS) (1.09–1.40), perfluorohexanesulfonic (PFHxS) (1.04–1.22), perfluorononanoic (PFNA) (1.12–1.42), total (1.21–1.81). We found that obesity mediator PFOA, PFNA, The ORs obtained by WQS adjusted model 1.10–1.46 1.08–1.32, respectively. Conclusions This study confirmed some increased Excessive exposure might explain high Koreans. Long‐term cohort studies needed assess geographic occupational exposures population.
Language: Английский