Benzo[a]pyrene-Induced Developmental Toxicity in Caenorhabditis elegans: Potential Involvement of Insulin/IGF Signaling and Collagen Gene Dysregulation DOI Creative Commons
Jinjin Zhou, Yufang Shi, Yanfeng Zhou

et al.

Toxics, Journal Year: 2025, Volume and Issue: 13(5), P. 384 - 384

Published: May 9, 2025

Benzo[a]pyrene (B[a]P) is a widespread and persistent organic pollutant that poses serious threats to human health. Although its carcinogenic properties have been extensively studied, developmental toxicity underlying mechanisms remain poorly understood. In this study, we employed Caenorhabditis elegans (C. elegans) as model organism investigate the effects of B[a]P exposure during early stages. To comprehensively assess B[a]P-induced toxicity, high-throughput sequencing along with transgenic mutant C. strains. Exposure at concentrations exceeding 1 mg/L significantly reduced larval body size, decreased number adult worms, delayed larval-to-adult development. Furthermore, analyzed expression genes involved in cuticle collagen synthesis key components insulin/insulin-like growth factor signaling (IIS) pathway, including daf-2 daf-16. These findings suggest may be associated dysregulation IIS pathway. Specifically, appears influence activity downstream transcription daf-16, thereby altering collagen-related genes. This disruption contribute development impaired maturation. Our study provides new insights into environmental hazards reveals potential mechanism toxicity. Moreover, our highlight critical role gene regulation serve biomarkers for toxicant exposure, particularly vulnerable populations such children undergoing periods

Language: Английский

Ligusticum chuanxiong: a chemical, pharmacological and clinical review DOI Creative Commons
Yin Wang,

Liuyun Wu,

H. Wang

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 1, 2025

The dried rhizome of Ligusticum chuanxiong S.H.Qiu, Y.Q.Zeng, K.Y.Pan, Y.C.Tang and J.M.Xu (Apiaceae; including the horticultural variety Hort.) [synonym: Conioselinum anthriscoides (H.Boissieu) Pimenov Kljuykov (The taxonomic classification has been adopted by World Checklist Vascular Plants)] is a traditional Chinese botanical drug renowned for its anti-inflammatory antioxidant properties. It widely used to treatment various diseases, particularly cardio-cerebral vascular diseases (CCVDs). This review aims summarize recent advances in (CX) research, chemical composition pharmacological effects, modern clinical applications. A systematic literature search was conducted using keywords such as "Chuanxiong," "traditional medicine," "chemical components," "metabolites," "CCVDs," "pharmacological effects" identify relevant published between 2014 2025. Databases PubMed, Web Science, Google Scholar, CNKI were utilized. Chemical structures SMILES format retrieved from PubChem, two-dimensional generated ChemDraw Ultra 8.0. Classical prescriptions obtained authoritative medicine databases. Over 100 metabolites have isolated identified CX, classified into nine major classes. Key bioactive compounds include senkyunolide A, ligustilide, tetramethylpyrazine (TMP), ligusticum CX polysaccharides (LCP). demonstrates significant effects treating CCVDs, atherosclerosis (AS), myocardial cerebral ischemia-reperfusion injury, hypertension. Its therapeutic mechanisms antiplatelet activity, endothelial cell protection, anti-inflammatory, antioxidant, anti-apoptotic can be administered alone or combination with other medicines (TCMs) drugs, showing efficacy cardiovascular, nervous system, digestive system disorders, well analgesia anticancer activities. holds substantial value multi-system extensive evidence supporting use CCVDs. Further research exploration are warranted fully harness potential.

Language: Английский

Citations

0
Benzo[a]pyrene-Induced Developmental Toxicity in Caenorhabditis elegans: Potential Involvement of Insulin/IGF Signaling and Collagen Gene Dysregulation DOI Creative Commons
Jinjin Zhou, Yufang Shi, Yanfeng Zhou

et al.

Toxics, Journal Year: 2025, Volume and Issue: 13(5), P. 384 - 384

Published: May 9, 2025

Benzo[a]pyrene (B[a]P) is a widespread and persistent organic pollutant that poses serious threats to human health. Although its carcinogenic properties have been extensively studied, developmental toxicity underlying mechanisms remain poorly understood. In this study, we employed Caenorhabditis elegans (C. elegans) as model organism investigate the effects of B[a]P exposure during early stages. To comprehensively assess B[a]P-induced toxicity, high-throughput sequencing along with transgenic mutant C. strains. Exposure at concentrations exceeding 1 mg/L significantly reduced larval body size, decreased number adult worms, delayed larval-to-adult development. Furthermore, analyzed expression genes involved in cuticle collagen synthesis key components insulin/insulin-like growth factor signaling (IIS) pathway, including daf-2 daf-16. These findings suggest may be associated dysregulation IIS pathway. Specifically, appears influence activity downstream transcription daf-16, thereby altering collagen-related genes. This disruption contribute development impaired maturation. Our study provides new insights into environmental hazards reveals potential mechanism toxicity. Moreover, our highlight critical role gene regulation serve biomarkers for toxicant exposure, particularly vulnerable populations such children undergoing periods

Language: Английский

Citations

0