Evaluation of the Reversibility of Cadmium-Induced Testicular Toxicity Following Recovery Alone or with Zinc Supplementation DOI Open Access

Jihane Ait Benbella,

Samy Housbane, Youness Kadil

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2025, Volume and Issue: 22(3), P. 454 - 454

Published: March 20, 2025

Cadmium (Cd) is a toxic heavy metal that disrupts spermatogenesis and steroidogenesis due to its long half-life. This study evaluated the impact of recovery alone or with zinc (Zn) supplementation on Cd-induced testicular toxicity. A total 42 pubertal male Wistar rats were divided into seven groups six each. The control group (1) received NaCl (0.9%). Groups 2, 3, 4 treated Cd 10 μg/kg/d by intraperitoneal injection for 1, 3 months respectively. Group 5 period 1 month; 6 was exposed months, followed 1-month combined Zn supplementation. (0.5 mg/kg/d). last at dose 0.5 mg/kg/day one month. results showed decreased body weight, epididymal dimensions, sperm parameters, along accumulation in testes. caused damage reduced serum testosterone levels, more pronounced effects 3-month treatment group. Recovery did not significantly reverse Cd’s effects, whereas mitigated most damage. effective correcting toxicity than alone.

Language: Английский

Non-occupational exposure to cadmium and breast cancer: A comprehensive and critical review DOI
Radomir Aničić, Milica Zeković,

M. Kocić

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 298, P. 118331 - 118331

Published: May 14, 2025

Language: Английский

Citations

0
Evaluation of the Reversibility of Cadmium-Induced Testicular Toxicity Following Recovery Alone or with Zinc Supplementation DOI Open Access

Jihane Ait Benbella,

Samy Housbane, Youness Kadil

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2025, Volume and Issue: 22(3), P. 454 - 454

Published: March 20, 2025

Cadmium (Cd) is a toxic heavy metal that disrupts spermatogenesis and steroidogenesis due to its long half-life. This study evaluated the impact of recovery alone or with zinc (Zn) supplementation on Cd-induced testicular toxicity. A total 42 pubertal male Wistar rats were divided into seven groups six each. The control group (1) received NaCl (0.9%). Groups 2, 3, 4 treated Cd 10 μg/kg/d by intraperitoneal injection for 1, 3 months respectively. Group 5 period 1 month; 6 was exposed months, followed 1-month combined Zn supplementation. (0.5 mg/kg/d). last at dose 0.5 mg/kg/day one month. results showed decreased body weight, epididymal dimensions, sperm parameters, along accumulation in testes. caused damage reduced serum testosterone levels, more pronounced effects 3-month treatment group. Recovery did not significantly reverse Cd’s effects, whereas mitigated most damage. effective correcting toxicity than alone.

Language: Английский

Citations

0