The Association Between Per- and Polyfluoroalkyl Substances Exposure and Thyroid Hormones in Men and Non-Pregnant Women: A Systematic Review and Meta-Analysis DOI Creative Commons
Bin Zhang, Miao Zhao,

Xiangru Cong

et al.

Toxics, Journal Year: 2025, Volume and Issue: 13(3), P. 214 - 214

Published: March 14, 2025

Studies have shown that per- and polyfluoroalkyl substances (PFAS) may impact thyroid function in human health. While the consistency between PFAS exposure health effects pregnant women has been validated, on men non-pregnant remains inconclusive. To address this, a meta-analysis was carried out this paper, with 14 eligible studies retrieved from Embase, PubMed, Web of Science were published up to 2 June 2024, focusing relationship its effect hormone levels body. The indexes analyzed included stimulating (TSH), triiodothyronine (T3), thyroxine (T4), free T3 (FT3), T4 (FT4). estimated value (β) corresponding confidence interval (95% CI) extracted literature. A heterogeneity test out, sensitivity analysis publication bias using Stata 18.0. results revealed women, PFOA positively correlated FT3 (β = 0.011, 95% CI 0.001, 0.02, I2 13.4). However, no significant associations found other hormones. subgroup further indicated correlations more adolescents, both America Europe.

Language: Английский

The Association Between Per- and Polyfluoroalkyl Substances Exposure and Thyroid Hormones in Men and Non-Pregnant Women: A Systematic Review and Meta-Analysis DOI Creative Commons
Bin Zhang, Miao Zhao,

Xiangru Cong

et al.

Toxics, Journal Year: 2025, Volume and Issue: 13(3), P. 214 - 214

Published: March 14, 2025

Studies have shown that per- and polyfluoroalkyl substances (PFAS) may impact thyroid function in human health. While the consistency between PFAS exposure health effects pregnant women has been validated, on men non-pregnant remains inconclusive. To address this, a meta-analysis was carried out this paper, with 14 eligible studies retrieved from Embase, PubMed, Web of Science were published up to 2 June 2024, focusing relationship its effect hormone levels body. The indexes analyzed included stimulating (TSH), triiodothyronine (T3), thyroxine (T4), free T3 (FT3), T4 (FT4). estimated value (β) corresponding confidence interval (95% CI) extracted literature. A heterogeneity test out, sensitivity analysis publication bias using Stata 18.0. results revealed women, PFOA positively correlated FT3 (β = 0.011, 95% CI 0.001, 0.02, I2 13.4). However, no significant associations found other hormones. subgroup further indicated correlations more adolescents, both America Europe.

Language: Английский

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