Correlation Between Fecal Microbiota and Corticosteroid Responsiveness in Primary Immune Thrombocytopenia: an Exploratory Study

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Corticosteroids (CSs) are the initial therapy for immune thrombocytopenia (ITP); however, their efficacy is not adequately predicted. As a novel biomarker, composition of gut microbiota non-invasively tested and altered in patients with ITP. This study aims to develop predictive model that leverages microbiome data predict CS response ITP within four weeks treatment. Metagenomic sequencing performed on fecal samples from 212 ITP, 152 whom underwent treatment follow-up. Predictive models trained using six machine-learning algorithms, integrating clinical indices data. The support vector machine (SVM) algorithm-based has highest accuracy (AUC = 0.80). utilized comprehensive feature set combined (including sex, age, duration, platelet count, bleeding scales) selected microbial species Bacteroides ovatus, xylanisolvens, Parabacteroides gordonii), alpha diversities, KEGG pathways, modules. will provide new ideas prediction efficacy, enabling informed decision-making regarding initiation or personalized

Language: Английский

Dermatologic toxicities related to cancer immunotherapy

Toxicology Reports, Journal Year: 2025, Volume and Issue: unknown, P. 102021 - 102021

Published: April 1, 2025

Language: Английский

Autoimmune-related adverse events induced by immune checkpoint inhibitors

Current Opinion in Immunology, Journal Year: 2025, Volume and Issue: 94, P. 102556 - 102556

Published: April 11, 2025

Language: Английский