Irish Journal of Medical Science (1971 -), Journal Year: 2022, Volume and Issue: 192(4), P. 1779 - 1784
Published: Sept. 17, 2022
Language: Английский
F&S Reviews, Journal Year: 2023, Volume and Issue: 4(2), P. 152 - 173
Published: March 12, 2023
Objective To evaluate whether the use of assisted reproductive techniques (ARTs) affected gonadal function offspring. Numerous concerns have emerged over years about ARTs and their effects on health Evidence Review Data were extracted through extensive searches in PubMed Scopus databases from establishment until August 2022. Meta-analysis was performed following Preferred Reporting Items for Systematic Meta-Analysis Protocols guidelines. All eligible studies selected according to Population, Exposure, Comparison/Comparator, Outcomes, Study design model. that analyzed pubertal development testicular ovarian offspring conceived using included. The quality assessed Cambridge Quality Checklists. For different outcomes, standardized mean difference (SMD), difference, odds ratio evaluated. Cochran-Q I2 statistics used statistical heterogeneity. Differences development, hormone levels, sperm ART-conceived subjects compared with spontaneously (SC) control subjects. Results Children ART do not appear impaired or achievement milestones. From an endocrine point view, males showed lower sex hormone-binding globulin levels than group (SMD = −0.25 [−0.44, −0.05]; 29%) a tendency testosterone −0.16 [−0.32, 0.01]; 0). Lower inhibin B, other hand, present only intracytoplasmic injection-born −0.24 −0.04]; In females, higher luteinizing found 0.33 [0.06, 0.59]; 17%). contrast, 17ß-estradiol observed injection girls SC −0.39 [−0.74, −0.03]; However, no definitive conclusions can be drawn considering heterogeneity hormonal assessments females. Finally, young adults born had reduced concentration −0.34 [−0.57, −0.11]; 0), total count −0.28 [−0.51, normal morphology −0.35 [−0.58, −0.13]; 0) those SC. Conclusion A slight alteration male germinal epithelium appears associated ART, as shown by B altered parameters.
Language: Английский
Citations
1
Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)
Published: Oct. 26, 2023
Abstract The mechanisms underlying male infertility are poorly understood. Most mammalian spermatozoa have two centrioles: the typical barrel-shaped proximal centriole (PC) and atypical fan-like distal (DC) connected to axoneme (Ax). These structures essential for fertility. However, relationship between quality subfertility (reduced fertility) is not well established. Here, we tested hypothesis that assessing sperm can identify cattle subfertility. By comparing from 25 fertile 6 subfertile bulls, all with normal semen analyses, found unexplained lower sire conception rates (pregnancy rate artificial insemination in cattle) correlate abnormal centriolar biomarker distribution. Fluorescence-based Ratiometric Analysis of Sperm Centrioles (FRAC) only four bulls (4/25, 16%) had positive FRAC tests (having one or more mean ratios outside distribution range a group’s high-quality population), whereas (6/6, 100%) ( P = 0.00008). most sensitive was acetylated tubulin, which novel labeling pattern DC Ax. data suggest tubulin bull remains undetected by current methods may provide insight into mechanism
Language: Английский
Citations
1
Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown
Published: Aug. 4, 2023
Abstract The mechanisms underlying male infertility are poorly understood. Most mammalian spermatozoa have two centrioles: the typical barrel-shaped proximal centriole (PC) and atypical fan-like distal (DC) connected to axoneme (Ax). These structures essential for fertility. However, relationship between quality subfertility (reduced fertility) is not well established. Here, we tested hypothesis that assessing sperm can identify cattle subfertility. By comparing from 25 fertile 6 subfertile bulls, all with normal semen analyses, found unexplained lower sire conception rates (pregnancy rate artificial insemination in cattle) corelate abnormal centriolar biomarker distribution. Fluorescence-based Ratiometric Analysis of Sperm Centrioles (FRAC) only four bulls (4/25, 16%) had positive FRAC tests (having one or more mean ratios outside distribution range a group’s high-quality population), whereas (6/6 , 100%) (P=0.00008). most sensitive was Acetylated Tubulin, which novel labeling pattern DC Ax. data suggest Tubulin bull remains undetected by current methods may provide insight into mechanism
Language: Английский
Citations
0
Deleted Journal, Journal Year: 2023, Volume and Issue: 18(4), P. 65 - 73
Published: Dec. 30, 2023
An estimated 12–20% of couples struggle with infertility, which is described as not becoming pregnant after a year trying. About one-third these are infertile because female factors, and another third male factors. A combination the two may be experienced by in remaining one-third. Its distributed into groups: primary secondary. There were total 60 participants, 30 whom older women (>35) younger (<35). In this study, results was statistically highly significant positive correlation between GH both serum follicular fluid (FF), FSH (0.84, 0.81 mIU/ML), LH (0.76, 0.74 mIU/ML) AMH (0.89, 0.86 there number retrieval Oocyte (0.47, 0.46 negatively found abortions (-0.10, -0.14 mIU/ML). Notably, vast majority assessments hormone levels revealed FSH, LH, AMH, frequency miscarriages, oocytes, infertility duration. These findings imply strong fertility. As result, much research required to assess estimate importance on women's fertility get an early level assessment before beginning GH-containing therapy program.
Language: Английский
Citations
0
Irish Journal of Medical Science (1971 -), Journal Year: 2022, Volume and Issue: 192(4), P. 1779 - 1784
Published: Sept. 17, 2022
Language: Английский
Citations
0