At the nucleus of cancer: how the nuclear envelope controls tumor progression

MedComm, Journal Year: 2025, Volume and Issue: 6(2)

Published: Jan. 24, 2025

Abstract Historically considered downstream effects of tumorigenesis—arising from changes in DNA content or chromatin organization—nuclear alterations have long been seen as mere prognostic markers within a genome‐centric model cancer. However, recent findings placed the nuclear envelope (NE) at forefront tumor progression, highlighting its active role mediating cellular responses to mechanical forces. Despite significant progress, precise interplay between NE components and cancer progression remains under debate. In this review, we provide comprehensive up‐to‐date overview how composition affect mechanics facilitate malignant transformation, grounded latest molecular functional studies. We also review research that uses advanced technologies, including artificial intelligence, predict malignancy risk treatment outcomes by analyzing morphology. Finally, discuss progress understanding has paved way for mechanotherapy—a promising approach exploits differences cancerous healthy cells. Shifting perspective on diagnostic potential therapeutic targets, calls further investigation into evolving cancer, innovative strategies transform conventional therapies.

Language: Английский

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Design, Synthesis, Computational Studies and Evaluation of Novel 2, 4, 5-Trisubstituted Pyrimidine Derivatives for Anticancer Activity against MCF-7 and A549 Cell Lines

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: unknown, P. 140987 - 140987

Published: Dec. 1, 2024

Language: Английский

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VRK2 kinase pathogenic pathways in cancer and neurological diseases

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Journal Year: 2025, Volume and Issue: unknown, P. 119949 - 119949

Published: April 1, 2025

Language: Английский

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