The Impact of a Yoga-Based Mindfulness Intervention versus Psycho-Educational Session for Older Adults with Mild Cognitive Impairment: The Protocol of a Randomized Controlled Trial DOI Open Access
Maryam Farhang, Graciela Rojas, Pablo Martínez

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(22), P. 15374 - 15374

Published: Nov. 21, 2022

Background: There is a global agreement in the medical community that significant proportion of dementia cases could be prevented or postponed. One factors behind this comes from scientific evidence showing mind-body interventions such as mindfulness and yoga for elderly have been related to range positive outcomes, including improved cognition performance seniors with mild cognitive impairment (MCI). Objective: This study aims evaluate effectiveness yoga-based intervention (YBM) versus psychoeducational sessions older adults MCI attending Hospital Clinic Universidad de Chile Santiago. Method: Two-arm, individually randomized controlled trial (RCT) will carried out at Clinical Older people over 60 years any type using score < 21 Montreal Cognitive Assessment (MoCA) test 0.05 Dementia Rating (CDR) Scale; preserved activities daily living randomly assigned an allocation ratio 1:1 either active control group based on psycho-educational program. People who performed and/or last 6 months or/and psychiatric clinical diagnosis excluded study. Assessment, Lawton Instrumental Activities Daily Living Scale (IADL), Barthel Index (BI), Pemberton happiness index, Geriatric Anxiety Inventory (GAI) well Depression (GDS-5) administered by blinded outcomes assessors before random assignment (Pre-test), week following session (post-test), then after 3- 6-months follow-up. Results: The YBM protocol video recording has adapted designed. first RCT examine effects improving physical functions mental health Chilean diagnosed MCI. It expected implemented acceptable effective non-pharmacological option Conclusion: Providing evidence-based programs preventive therapy Alzheimer’s disease relevant implications public services Chile.

Language: Английский

Empagliflozin Improves the MicroRNA Signature of Endothelial Dysfunction in Patients with Heart Failure with Preserved Ejection Fraction and Diabetes DOI Open Access
Pasquale Mone, Angela Lombardi, Urna Kansakar

et al.

Journal of Pharmacology and Experimental Therapeutics, Journal Year: 2022, Volume and Issue: 384(1), P. 116 - 122

Published: July 25, 2022

Endothelial dysfunction represents a key mechanism underlying heart failure with preserved ejection fraction (HFpEF), diabetes mellitus (DM), and frailty. However, reliable biomarkers to monitor endothelial in these patients are lacking. In this study, we evaluated the expression of panel circulating microRNAs (miRs) involved regulation function frail older adults HFpEF DM that were treated for 3 months empagliflozin, metformin, or insulin. We identified unique pattern miRs significantly regulated compared healthy controls after treatment SGLT2 inhibitor empagliflozin. Three downregulated (miR-126, miR-342-3p, miR-638) two upregulated (miR-21 miR-92) controls. Strikingly, reduced 3-month empagliflozin whereas no significant differences profile miRNAs detected metformin Significance Statement have first time signature microRNA functionally is diabetes. The caused modification some direction was opposite what observed patients, indicating rescue function. Our findings relevant inasmuch as novel disease well response therapy been established.

Language: Английский

Citations

66
Frailty biomarkers under the perspective of geroscience: A narrative review DOI
Rafaella Silva dos Santos Aguiar Gonçalves, Álvaro Campos Cavalcanti Maciel, Yves Rolland

et al.

Ageing Research Reviews, Journal Year: 2022, Volume and Issue: 81, P. 101737 - 101737

Published: Sept. 23, 2022

Language: Английский

Citations

43
Insulin resistance drives cognitive impairment in hypertensive pre-diabetic frail elders: the CENTENNIAL study DOI
Pasquale Mone,

Stefano De Gennaro,

Divina Moriello

et al.

European Journal of Preventive Cardiology, Journal Year: 2023, Volume and Issue: 30(12), P. 1283 - 1288

Published: May 17, 2023

Abstract Aims Pre-diabetes is a condition that confers an increased cardiovascular risk. Frailty very common in hypertensive patients, and insulin resistance has been linked to frailty older adults with diabetes. On these grounds, our aim was evaluate the association between cognitive impairment pre-diabetic frail adults. Methods results We studied consecutive elders presenting at Avellino local health authority of Italian Ministry Health (ASL AV) from March 2021 2022. All them fulfilled following inclusion criteria: previous diagnosis hypertension no clinical or laboratory evidence secondary causes, confirmed pre-diabetes, age &gt;65 years, Montreal Cognitive Assessment (MoCA) Score &lt;26, frailty. enrolled 178 which 141 successfully completed study. observed strong inverse correlation (r = −0.807; P &lt; 0.001) MoCA Homeostatic Model for Insulin Resistance (HOMA-IR). The were by linear regression analysis using as dependent variable, after adjusting several potential confounders. Conclusion Taken together, data highlight first time global function pre-diabetes.

Language: Английский

Citations

33
Hyperglycemia drives the transition from pre-frailty to frailty: The Monteforte study DOI
Pasquale Mone,

Stefano De Gennaro,

Salvatore Frullone

et al.

European Journal of Internal Medicine, Journal Year: 2023, Volume and Issue: 111, P. 135 - 137

Published: Jan. 10, 2023

Language: Английский

Citations

23
Frail hypertensive older adults with prediabetes and chronic kidney disease: insights on organ damage and cognitive performance - preliminary results from the CARYATID study DOI Creative Commons

Gaetano Santulli,

Valeria Visco, Michele Ciccarelli

et al.

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: April 10, 2024

Abstract Background Hypertension and chronic kidney disease (CKD) pose significant public health challenges, sharing intertwined pathophysiological mechanisms. Prediabetes is recognized as a precursor to diabetes often accompanied by cardiovascular comorbidities such hypertension, elevating the risk of pre-frailty frailty. Albuminuria hallmark organ damage in hypertension amplifying pre-frailty, frailty, cognitive decline older adults. We explored association between albuminuria impairment frail adults with prediabetes CKD, assessing levels based on estimated glomerular filtration rate (eGFR). Methods conducted study involving consecutive patients recruited from March 2021 2023 at ASL (local unit Italian Ministry Health) Avellino, Italy, followed up after three months. Inclusion criteria comprised age over 65 years, prior diagnosis without secondary causes, prediabetes, frailty status, Montreal Cognitive Assessment (MoCA) score < 26, CKD eGFR > 15 ml/min. Results 237 completed study. examined MoCA Score, revealing inverse correlation (r: 0.8846; p 0.0001). Subsequently, we compared Score eGFR, observing difference ( These findings were further supported multivariable regression analysis, dependent variable. Conclusions Our represents pioneering effort establish function hypertensive afflicted CKD.

Language: Английский

Citations

14
Extended-release metformin improves cognitive impairment in frail older women with hypertension and diabetes: preliminary results from the LEOPARDESS Study DOI Creative Commons
Pasquale Mone,

Giuseppe Martinelli,

Angela Lucariello

et al.

Cardiovascular Diabetology, Journal Year: 2023, Volume and Issue: 22(1)

Published: April 21, 2023

Abstract Background Women have a high risk of frailty independently age and menopause state. Diabetes hypertension increase the cognitive impairment. Metformin has been employed in post-menopausal women some reports shown encouraging effects terms attenuated frailty. However, impact on performance recently introduced extended-release formulation metformin never explored. Methods We studied consecutive frail hypertensive diabetic older presenting at ASL (local health authority Italian Ministry Health) Avellino, Italy, from June 2021 to August 2022, who were treated or not with metformin. included control group males diabetes regular Results A total 145 patients successfully completed study. At end 6-month follow-up, we observed significantly different compared baseline (p: 0.007). Then, follow-up groups significant differences between vs. untreated 0.041), men 0.016), 0.048). confirmed crucial role applying multivariable logistic analysis adjust for potential confounders. Conclusions evidenced, first time best our knowledge, favorable impairment hypertension.

Language: Английский

Citations

16
Montreal Cognitive Assessment Hearing Impairment (MoCA-H): cross-cultural adaptation to Brazilian Portuguese DOI Creative Commons
Rochele Martins Machado, Karina Carlesso Pagliarin, Fernanda Soares Aurélio Patatt

et al.

CoDAS, Journal Year: 2025, Volume and Issue: 37(1)

Published: Jan. 1, 2025

ABSTRACT Purpose This study aimed to adapt the Montreal Cognitive Assessment Hearing Impaired (MoCA-H) into Brazilian Portuguese (BP). Methods was a descriptive, cross-sectional, quantitative, and qualitative involving participants selected by convenience. The instrument adapted from its original version, in six-stage process consisting of following: Stage 1 - Translation back translation MoCA-H; 2 Stimulus analysis selection; 3 Semantic stimuli; 4 Analysis non-expert judges, part 1; 5 2; 6 Pilot study. following statistical methods were used this study: parametric T-test, Gwet’s first-order Agreement Coefficient (AC1), Content Validity Ratio (CVR). Results Cultural linguistic adaptations made as well changes administration procedures improve respondent comprehension. Participants with without hearing loss had some comprehension difficulties visualspatial/executive domain task. observed not only but also beginning adaptation process. Conclusion yielded an satisfactory content validity.

Language: Английский

Citations

0
The Acute Effects of Motor Imagery Combined With Action Observation Breathing Exercise on Cardiorespiratory Responses, Brain Activity, and Cognition: A Randomized, Controlled Trial DOI Creative Commons
Ebrar Atak, Amine Ataç

Cardiovascular Therapeutics, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Breath and brain activity have been integral to daily life since time immemorial. Cognition cardiorespiratory responses are closely interlinked, necessitating further investigation into their dynamics. The potential benefits of combining motor imagery (MI) action observation (AO) based breathing exercises in rehabilitation not fully explored. This study was aimed at assessing the acute effects MI combined with AO on cognitive function responses. Thirty‐three healthy adults were randomized (MI+AO), active respiratory exercise (ARE), control groups, equal distribution across groups. Electroencephalography (EEG) data collected using a Muse EEG headband, assessed Montreal Cognitive Assessment (MoCA) while imagining activities measured via Kinesthetic Visual Imagery Questionnaire (KVIQ). Significant improvements Timed Up Go (TUG) test systolic blood pressure observed ARE group ( p < 0.05), alongside MoCA KVIQ scores 0.05). revealed significant decreases delta theta power temporoparietal (TP) location These findings suggest that AO, when exercises, may serve as effective passive strategies support cognition function, particularly individuals who struggle actively participate pulmonary rehabilitation. Trial Registration: ClinicalTrials.gov identifier: NCT06099483

Language: Английский

Citations

0
Functional role of miR-34a in diabetes and frailty DOI Creative Commons
Pasquale Mone, Antonio De Donato, Fahimeh Varzideh

et al.

Frontiers in Aging, Journal Year: 2022, Volume and Issue: 3

Published: July 18, 2022

Emerging evidence has shown that microRNAs (miRNAs) play critical role in the pathogenesis of several disorders. In present minireview, we focus our attention on functional a specific miRNA, namely miR-34a, pathophysiology frailty and diabetes mellitus. Based current literature, speculate this miRNA may serve as potential biomarker diabetic older adults. Additionally, its actions oxidative stress might represent druggable target to obtain new potentials treatments.

Language: Английский

Citations

16
L-Arginine Improves Cognitive Impairment in Hypertensive Frail Older Adults DOI Creative Commons
Pasquale Mone,

Antonella Pansini,

Stanislovas S. Jankauskas

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2022, Volume and Issue: 9

Published: April 12, 2022

Cognitive impairment is a prevailing event in hypertensive patients and frail older adults. Endothelial dysfunction has been shown to underlie both hypertension cognitive dysfunction. Our hypothesis that L-Arginine, which known ameliorate endothelial dysfunction, could counteract high-risk population of We designed clinical trial verify the effects 4-weeks oral supplementation L-Arginine on global function patients. The study was successfully completed by 35 elderly assigned 37 placebo. At follow-up, we found significant difference Montreal Assessment (MoCA) test score between treated group placebo (p: 0.0178). Moreover, demonstrated significantly attenuates Angiotensin II-induced mitochondrial oxidative stress human cells. In conclusion, our findings indicate for first time improves adults.www.ClinicalTrials.gov, identifier: NCT04962841.

Language: Английский

Citations

14