Fish oil supplementation in relation to the risk of chronic kidney disease among patients with diabetes DOI
Ao Yang,

Hao Ye,

Xiaohui Liu

et al.

Diabetes Obesity and Metabolism, Journal Year: 2024, Volume and Issue: 26(11), P. 5283 - 5292

Published: Aug. 27, 2024

Abstract Aim To investigate the association between fish oil supplementation and subsequent risk of chronic kidney disease (CKD) among patients with diabetes, further evaluate mediation effect typical glycolipid inflammatory biomarkers. Methods In total, 24 497 diabetes from UK Biobank were included. Cox proportional hazards regression models used to estimate hazard ratios (HRs) 95% confidence intervals (CIs) for CKD risk, rate advancement period was calculated quantify communicate impact upon that risk. addition, we also analysis assess mediating role plasma Results Overall, 7122 reported taking supplements. During a mean 11.3 years follow‐up, 3533 cases occurred. fully adjusted model, use inversely associated incidence (HR 0.90; CI: 0.83, 0.97), which mediated by serum levels HbA1c (4.7%), C‐reactive protein (CRP) (3.4%) high‐density lipoprotein cholesterol (HDL‐C) (2.3%). Participants who took supplements displayed same events, but delayed approximately 2.79 compared non‐users oil. Conclusions Our findings advocate beneficial in preventing may be HbA1c, CRP HDL‐C, support public health policies aiming promote prevention complications.

Language: Английский

The association of fasting triglyceride variability with renal dysfunction and proteinuria in medical checkup participants DOI Creative Commons
Natsumi Matsuoka‐Uchiyama, Haruhito A. Uchida,

Tomohiko Asakawa

et al.

Clinical and Experimental Nephrology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

Language: Английский

Citations

0
Lipid abnormality in diabetic kidney disease and potential treatment advancements DOI Creative Commons

Qian Tu,

Hui Jin,

Xiu Hong Yang

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: March 18, 2025

Numerous studies have shown that dyslipidemia increases the risk of atherosclerotic cardiovascular disease (ASCVD) and significantly impacts occurrence progression diabetic kidney (DKD). Early interventions for lipid metabolism disorders in DKD may improve renal function. This article reviews clinical characteristics dyslipidemia, mechanisms lipid-induced injury, advances lipid-lowering therapy DKD. We searched PubMed, Web Science, EMBASE to identify relevant articles, using keywords such as "diabetic disease", nephropathy", "diabetes", "dyslipidemia", "kidney", "cardiovascular "lipid therapy". High triglyceride (TG) low high-density lipoprotein (HDL) are associated with increased risks albuminuria estimated glomerular filtration rate (eGFR) decline. Abnormal damage podocytes tubular epithelial cells via ectopic deposition, eventually impairing function increasing urinary albumin excretion. Lipid-lowering therapies can ameliorate accumulation, downregulate inflammatory mediator expressions, alleviate fibrosis. Fibrate statin applications exhibit beneficial effects, reducing slowing eGFR decline early However, long-term effects statins fibrates on outcomes remain controversial. Pro-protein convertase subtilisin/kexin 9 (PCSK9)-targeted minimal side kidneys seem effective inflammation improving impairment compared fibrates. In addition, LDL apheresis (LDL-A) double plasmapheresis (DFPP) promising patients severe hypercholesterolemia or drug intolerance.

Language: Английский

Citations

0
The Effect of Increased Plant Protein Intake on the Lipid Profile of Chronic Kidney Disease Patients: A Meta-Analysis of Controlled Clinical Trials DOI Open Access

Ioanna Papaodyssea,

Areti Lagiou, Ioanna Tzoulaki

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1408 - 1408

Published: April 23, 2025

Background/Objectives: Chronic kidney disease (CKD) is associated with increased mortality, cardiovascular (CVD) being the primary cause of death. Proper lipid regulation may reduce CVD risk and slow CKD progression. While there evidence that a higher plant protein intake could ameliorate levels in general population, effects this dietary regimen within population remain uncertain, studies providing conflicting results. We aim to investigate impact on patients. Methods: Two electronic databases (PubMed, Scopus) were reviewed for controlled clinical trials assessing effect versus usual animal-based diet patients, published until June 2024. Results: Eleven trials, encompassing 248 included meta-analysis. Overall, compared usually recommended diet, was statistically significant reductions total cholesterol (−24.51 mg/dL, 95% CI −40.33, −8.69), low-density lipoprotein (LDL) (−21.71 −38.32, −5.1), triglycerides (− 21.88 −35.34, −8.40), Apolipoprotein B (−11.21 −18.18, −4.25). No changes observed high-density (HDL) (0.09 −1.82, 1.99) A (0.04 −7.14, 7.21). Conclusions: Increased intake, mainly from soy, reduces cholesterol, LDL, triglycerides, ApoB adult Further research needed assess these dialysis patients explore non-soy sources.

Language: Английский

Citations

0
Beneficial Effect of Fenofibrate in Combination with Silymarin on Parameters of Hereditary Hypertriglyceridemia-Induced Disorders in an Animal Model of Metabolic Syndrome DOI Creative Commons
Jan Soukop, Ludmila Kazdová, Martina Hüttl

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(1), P. 212 - 212

Published: Jan. 16, 2025

Background: Hypertriglyceridemia has serious health risks such as cardiovascular disease, type 2 diabetes mellitus, nephropathy, and others. Fenofibrate is an effective hypolipidemic drug, but its benefits for ameliorating disorders associated with hypertriglyceridemia failed to be proven in clinical trials. Methods: To search possible causes of this situation possibilities their favorable influence, we tested the effect FF monotherapy combination fenofibrate silymarin on metabolic a unique model hereditary hypertriglyceridemic rats (HHTg). Results: treatment (100 mg/kg BW/day four weeks) significantly decreased serum levels triglyceride, (−77%) free fatty acids (−29%), hepatic accumulation triglycerides, expression genes encoding transcription factors involved lipid metabolism (Srebf2, Nr1h4. Rxrα, Slco1a1). In contrast, hypertriglyceridemia-induced ectopic storage lipids muscles, heart, kidneys reduced glucose utilization muscles was not affected. addition, activity antioxidant system, including Nrf2 (−35%) increased lipoperoxidation liver and, lesser extent, heart. Adding (micronized form, 600 BW/day) therapy synthesis glycogen (+36%) hyperinsulinemia (−34%). liver, it PON-1 expression, formation lipoperoxides. The beneficial parameters oxidative stress also observed, heart kidneys. Conclusions: Our results suggest potential use SLM disorders.

Language: Английский

Citations

0
The vicious circle of chronic kidney disease and hypertriglyceridemia: what is first, the hen or the egg? DOI Creative Commons
Thiago Medeiros da Costa Daniele, Laura De Marchis,

Larouche Miriam

et al.

Atherosclerosis, Journal Year: 2025, Volume and Issue: 403, P. 119146 - 119146

Published: Feb. 24, 2025

Chronic kidney disease (CKD) is documented to cause alterations in lipid metabolism, and this was considered a potent driver of increased cardiovascular risk. Among the diverse alteration traits CKD, research endeavours have predominantly concentrated on low-density lipoproteins (LDL) view pro-atherogenic role these lipoprotein particles demonstration protective effect reducing LDL. However, few studies focused metabolism triglyceride-rich even fewer their causing damage. Therefore, comprehensive description impact hypertriglyceridemia (HTG) CKD pathophysiology remains largely undetermined. This reflects difficulty disentangling independent triglycerides (TG) complex, bidirectional relationship between TG disease. Abnormal neutral accumulation intrarenal vasculature renal cells eventually due HTG may also promote glomerular injury, throughout mechanisms including oxidative stress, mitochondrial dysfunction proinflammatory responses. While epidemiological experimental evidence suggests potential damage, causal clinical relevance remain unclear, representing significant area for future investigation. review aims highlight intricate interplay disease, shedding light through which influence functionality.

Language: Английский

Citations

0
The effect of metabolic factors on the association between hyperuricemia and chronic kidney disease: a retrospective cohort mediation analysis DOI

Hua Lin,

Shuo Geng, Libo Yang

et al.

International Urology and Nephrology, Journal Year: 2024, Volume and Issue: 56(7), P. 2351 - 2361

Published: Feb. 21, 2024

Language: Английский

Citations

2
Hypertriglyceridemia: Molecular and Genetic Landscapes DOI Open Access
Pietro Scicchitano, Francesca Amati, Marco Matteo Ciccone

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(12), P. 6364 - 6364

Published: June 8, 2024

Lipid disorders represent one of the most worrisome cardiovascular risk factors. The focus on impact lipids cardiac and vascular health usually concerns low-density lipoprotein cholesterol, while role triglycerides (TGs) is given poor attention. literature provides data higher plasma concentrations in TGs system and, therefore, outcomes comorbidities patients. for coronary heart diseases varies from 57 to 76% patients with hypertriglyceridemia. Specifically, TGs, incidence prevalence death, myocardial infarction, stroke. Nevertheless, metabolism exact physiopathologic mechanisms which try explain relationship between are not completely understood. aims this narrative review were as follows: provide a comprehensive evaluation possible suggestion understanding targets counteracting hypertriglyceridemia; describe inner physiopathological background damages derived TGs; outline need promoting further insights therapies reducing levels.

Language: Английский

Citations

2
Fish oil supplementation in relation to the risk of chronic kidney disease among patients with diabetes DOI
Ao Yang,

Hao Ye,

Xiaohui Liu

et al.

Diabetes Obesity and Metabolism, Journal Year: 2024, Volume and Issue: 26(11), P. 5283 - 5292

Published: Aug. 27, 2024

Abstract Aim To investigate the association between fish oil supplementation and subsequent risk of chronic kidney disease (CKD) among patients with diabetes, further evaluate mediation effect typical glycolipid inflammatory biomarkers. Methods In total, 24 497 diabetes from UK Biobank were included. Cox proportional hazards regression models used to estimate hazard ratios (HRs) 95% confidence intervals (CIs) for CKD risk, rate advancement period was calculated quantify communicate impact upon that risk. addition, we also analysis assess mediating role plasma Results Overall, 7122 reported taking supplements. During a mean 11.3 years follow‐up, 3533 cases occurred. fully adjusted model, use inversely associated incidence (HR 0.90; CI: 0.83, 0.97), which mediated by serum levels HbA1c (4.7%), C‐reactive protein (CRP) (3.4%) high‐density lipoprotein cholesterol (HDL‐C) (2.3%). Participants who took supplements displayed same events, but delayed approximately 2.79 compared non‐users oil. Conclusions Our findings advocate beneficial in preventing may be HbA1c, CRP HDL‐C, support public health policies aiming promote prevention complications.

Language: Английский

Citations

1