Electrospun-based nanofibers as ROS-scavenging scaffolds for accelerated wound healing: a narrative review DOI

Mohammad Ebrahim Astaneh,

Narges Fereydouni

International Journal of Polymeric Materials, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 33

Published: Dec. 16, 2024

This review delves into the efficacy of electrospun nanofibers as structures capable neutralizing Reactive Oxygen Species (ROS), thereby aiding in acceleration wound repair. ROS occupy a dual position cellular dynamics, being indispensable for intracellular communication, yet they potentially exacerbate oxidative stress which can stall healing trajectory. The method electrospinning synthesizes distinguished by their expansive surface area relative to volume and notable porosity, rendering them optimally suited medical endeavors, particularly frameworks that bolster recuperation. analysis elucidates diverse roles these play, from enhancing clot formation combating microbial invasion mitigating inflammation, fostering proliferation, facilitating angiogenesis—each pivotal component effective mending wounds.

Language: Английский

Chitosan and its derivatives: A novel approach to gut microbiota modulation and immune system enhancement DOI
Great Iruoghene Edo, Alice Njolke Mafe,

Ali B. M. Ali

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 289, P. 138633 - 138633

Published: Dec. 13, 2024

Language: Английский

Citations

9
Nanoparticle-Encapsulated Plant Polyphenols and Flavonoids as an Enhanced Delivery System for Anti-Acne Therapy DOI Creative Commons
Ririn Puspadewi, Tiana Milanda, Muhaimin Muhaimin

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(2), P. 209 - 209

Published: Feb. 4, 2025

This study conducted a literature review by searching for articles related to the treatment of skin infections/wrinkles using nano-delivery systems containing natural compounds. The search was in various databases published last 10 years, with strict inclusion and exclusion criteria. Of 490 found, 40 were considered relevant. Acne vulgaris is common dermatological disorder characterised inflammation sebaceous glands, often resulting development pimples, cysts, scarring. Conventional treatments, including antibiotics topical retinoids, frequently demonstrate limitations such as side effects, resistance, insufficient absorption. Recent advancements nanotechnology have enabled creation innovative drug-delivery that enhance effectiveness reduce adverse effects anti-acne medications. Polyphenols flavonoids, bioactive compounds notable anti-inflammatory, antioxidant, antibacterial properties, are recognised their therapeutic acne treatment. However, practical application hindered solubility, stability, bioavailability. incorporation these into nanoparticle-based delivery has shown promise resolving challenges. Various nanoparticle platforms, lipid-based nanoparticles, polymeric solid lipid evaluated ability improve controlled release, targeted polyphenols flavonoids skin. advent polyphenol flavonoid-loaded nanoparticles marks new therapy era.

Language: Английский

Citations

1
A semi-transparent strong biomimetic wound healing material: zinc oxide and sodium alginate based bi-layer nanofiber membrane DOI Creative Commons
Muzammil Kuddushi, Tanay Kumar, Hongyan Wu

et al.

Advanced Composites and Hybrid Materials, Journal Year: 2025, Volume and Issue: 8(2)

Published: Feb. 20, 2025

Language: Английский

Citations

0
Hydrotalcite Supported on Polycaprolactone:Poly(methyl methacrylate) Fiber Membranes for Chlorogenic Acid Removal DOI Open Access

A. Nascimento,

João Otávio Donizette Malafatti, Maria Luiza Lopes Sierra e Silva

et al.

Water, Journal Year: 2025, Volume and Issue: 17(7), P. 931 - 931

Published: March 22, 2025

Polyphenols are organic molecules extracted from various fruits, such as coffee and citrus, that possess biological activity antioxidant properties. However, the presence of polyphenols in environment is hazardous to water quality living health. Among a variety remediation methods, adsorption remains staple field. Therefore, this work aims develop porous polycaprolactone: poly(methyl methacrylate) (PCL:PMMA) membranes support for hydrotalcite immobilization removal chlorogenic acid polyphenol (CGA) aqueous solutions. Due hydrophilic nature hydrotalcite, adsorbent was functionalized with hexadecyltrimethylammonium bromide (CTAB) increase its affinity CGA, resulting efficiency approximately 96%. Composite fiber were prepared by solution-blowing spinning specific amounts added (i.e., 1 60 wt%). A 3:1 PCL:PMMA blend resulted superior mechanical traction (0.8 MPa) stress deformation (70%) compared pure PCL (0.7 MPa 37%) PMMA (0.1 5%) fibers. 60% LDH-CTAB exhibited CGA rates equal 55% first cycle while maintaining capacity remove 30% after five consecutive reuses. Removal up 90% could also be achieved an appropriate dose (2 g L−1). Adsorption found follow pseudo-second-order kinetics adequately described Langmuir model, saturating active sites four hours. PCL:PMMA:LDH-CTAB composites can considered potential alternative adsorbents remediation.

Language: Английский

Citations

0
Nanofiber Application in Wound Healing DOI
Fatimah Ahmedy,

Nur Syazana Aqila Mhd Sazuli,

Lubna Abdul Kadir

et al.

IGI Global eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 289 - 326

Published: April 11, 2025

Nanofiber technology presents significant potential across various medical applications, with particular emphasis on its role in wound healing. This chapter examines the ability of nanofibers to mimic extracellular matrix, facilitating critical processes such as cell adhesion, migration, nutrient and oxygen delivery, inflammation modulation, controlled release bioactive molecules. These properties position optimal candidates for advanced dressings, biodegradable scaffolds, cell-seeded constructs. Empirical studies substantiate their efficacy mitigating inflammation, preventing infections, minimizing scar formation. However, challenges persist, including issues related scalability, cost-effectiveness, mechanical stability, biocompatibility, regulatory approval. concludes by addressing these outlining research gaps that must be bridged fully harness nanofiber technology, particularly long-term safety, mechanistic insights, adaptation low-resource settings.

Language: Английский

Citations

0
Asoprisnil as a Novel Ligand Interacting with Stress-Associated Glucocorticoid Receptor DOI Creative Commons
Ovinuchi Ejiohuo, Donald Bajia, Joanna Pawlak

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2745 - 2745

Published: Nov. 30, 2024

Background/objective: The glucocorticoid receptor (GR) is critical in regulating cortisol production during stress. This makes it a key target for treating conditions associated with hypothalamic-pituitary-adrenal (HPA) axis dysregulation, such as mental disorders. study explores novel ligands beyond mifepristone their potential to modulate GR improved efficacy and safety. By investigating these interactions, we seek identify new pharmacotherapeutic options stress-related illness. Methods: asoprisnil, campestanol, stellasterol were selected based on structural similarities (reference ligand) evaluated pharmacological ADME (absorption, distribution, metabolism, excretion) properties using the SwissADME database. Molecular docking AutoDock 4.2.6 molecular dynamics simulations performed investigate ligand-protein interactions human receptor, binding free energies calculated MMPBSA. Results: Pharmacokinetic analysis revealed that asoprisnil exhibited high gastrointestinal absorption obeyed Lipinski's rule, while crossed blood-brain barrier. Toxicological predictions showed was active neurotoxicity immunotoxicity, displayed lower toxicity profiles. Asoprisnil demonstrated highest stability simulations, negative energy of -62.35 kcal/mol, when compared mifepristone, stellasterol, -57.08 -49.99 -46.69 respectively. Conclusion: potentially favourable therapeutic candidate mifepristone. However, further validation asoprisnil's interaction, efficacy, safety disorders through experimental studies clinical trials needed.

Language: Английский

Citations

1
Electrospun-based nanofibers as ROS-scavenging scaffolds for accelerated wound healing: a narrative review DOI

Mohammad Ebrahim Astaneh,

Narges Fereydouni

International Journal of Polymeric Materials, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 33

Published: Dec. 16, 2024

This review delves into the efficacy of electrospun nanofibers as structures capable neutralizing Reactive Oxygen Species (ROS), thereby aiding in acceleration wound repair. ROS occupy a dual position cellular dynamics, being indispensable for intracellular communication, yet they potentially exacerbate oxidative stress which can stall healing trajectory. The method electrospinning synthesizes distinguished by their expansive surface area relative to volume and notable porosity, rendering them optimally suited medical endeavors, particularly frameworks that bolster recuperation. analysis elucidates diverse roles these play, from enhancing clot formation combating microbial invasion mitigating inflammation, fostering proliferation, facilitating angiogenesis—each pivotal component effective mending wounds.

Language: Английский

Citations

0