Design, synthesis, and biological evaluation of novel capsaicin-tacrine hybrids as multi-target agents for the treatment of Alzheimer's disease

Bioorganic Chemistry, Journal Year: 2023, Volume and Issue: 143, P. 107026 - 107026

Published: Dec. 13, 2023

Language: Английский

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Current Pharmaceutical Aspects of Synthetic Quinoline Derivatives

Mini-Reviews in Medicinal Chemistry, Journal Year: 2020, Volume and Issue: 21(10), P. 1152 - 1172

Published: Dec. 15, 2020

Quinoline derivatives are considered broad-spectrum pharmacological compounds that exhibit a wide range of biological activities. Integration quinoline moiety can improve its physical and chemical properties also behavior. Due to pharmaceutical applications, it is very popular compound design new drugs for the treatment multiple diseases like cancer, dengue fever, malaria, tuberculosis, fungal infections, AIDS, Alzheimer's disease diabetes. In this review, our major focus pay attention activities in these such as anti-viral, anti-cancer, anti-malarial, antibacterial, anti-fungal, anti-tubercular anti-diabetic.

Language: Английский

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Synthesis, molecular docking and molecular dynamics studies of novel tacrine-carbamate derivatives as potent cholinesterase inhibitors

Bioorganic Chemistry, Journal Year: 2021, Volume and Issue: 115, P. 105225 - 105225

Published: July 30, 2021

Language: Английский

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Multi-Target-Directed Ligands as an Effective Strategy for the Treatment of Alzheimer’s Disease

Current Medicinal Chemistry, Journal Year: 2021, Volume and Issue: 29(10), P. 1757 - 1803

Published: May 12, 2021

Abstract: Alzheimer’s disease (AD) is a complex neurological disorder and multiple pathological factors are believed to be involved in the genesis progression of dis-ease. A number hypothesis including Acetylcholinesterase, Monoamine oxidase, β-Amyloid, Tau protein etc. have been proposed for initiation disease. At present, acetylcholine esterase inhibitors memantine (NMDAR antago-nist) only approved therapy symptomatic management AD. Most these single-target drugs miserably failed treatment or halting Multi-factorial diseases like AD require strategies that involve simultaneous modulation network interacting targets. Since last few years, Multi-Target-Directed Ligands (MTDLs) strategy, can simultaneously hit mul-tiple targets, being explored as an effective therapeutic approach In current review article, authors briefly described various pathogenic pathways associated with Importance their design recently reported articles discussed detail. Potent leads identified through structure-activity relationship studies drug char-acteristics described. Recently developed promising compounds summa-rized article. Some MTDLs balanced activity profile against different targets potential candidates

Language: Английский

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Design, synthesis, and biological evaluation of diosgenin-indole derivatives as dual-functional agents for the treatment of Alzheimer’s disease

European Journal of Medicinal Chemistry, Journal Year: 2021, Volume and Issue: 219, P. 113426 - 113426

Published: April 3, 2021

Language: Английский

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