Sulfonamide derivatives as potential anti-cancer agents and their SARs elucidation

European Journal of Medicinal Chemistry, Journal Year: 2021, Volume and Issue: 226, P. 113837 - 113837

Published: Sept. 8, 2021

Language: Английский

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Applications of Sesquiterpene Lactones: A Review of Some Potential Success Cases

Applied Sciences, Journal Year: 2020, Volume and Issue: 10(9), P. 3001 - 3001

Published: April 25, 2020

Sesquiterpene lactones, a vast range of terpenoids isolated from Asteraceae species, exhibit broad spectrum biological effects and several them are already commercially available, such as artemisinin. Here the most recent impactful results in vivo, preclinical clinical studies involving selection ten sesquiterpene lactones (alantolactone, arglabin, costunolide, cynaropicrin, helenalin, inuviscolide, lactucin, parthenolide, thapsigargin tomentosin) presented discussed, along with some their derivatives. In authors’ opinion, these compounds have been neglected compared to others, although they could be great use developing important new pharmaceutical products. The selected sesquiterpenes show promising anticancer anti-inflammatory effects, acting on various targets. Moreover, antifungal, anxiolytic, analgesic, antitrypanosomal activities. Several discussed here clearly potential that combination therapy, sensitizing agents facilitate enhance action drugs use. derivatives greater pharmacological value since better pharmacokinetics, stability, potency, and/or selectivity. All natural properties invite further research by scientific community.

Language: Английский

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Current scenario of indole derivatives with potential anti-drug-resistant cancer activity

European Journal of Medicinal Chemistry, Journal Year: 2020, Volume and Issue: 200, P. 112359 - 112359

Published: April 27, 2020

Language: Английский

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Electrospun Nanofibers of Polycaprolactone/Collagen as a Sustained-Release Drug Delivery System for Artemisinin

Pharmaceutics, Journal Year: 2021, Volume and Issue: 13(8), P. 1228 - 1228

Published: Aug. 9, 2021

The application of artemisinin (ART) in the treatment malaria has been restricted to a certain degree due its inherent limitations, such as short half-life, poor solubility, limited bioavailability, and re-crystallization. Electrospun nanofibers loaded with ART provide an excellent solution these limitations yield sustained drug release well inhibition In this study, ART-loaded polycaprolactone (PCL)/collagen (Col) different proportions polymers were prepared. PCL/Col characterized, further anti-crystallization behaviors studied. SEM was used observe morphology nanofibers. X-ray diffraction (XRD) characterize physical state Fourier transform infrared spectroscopy (FTIR), water contact angle measurement, weight loss, swelling, experiments can verify differences performance polymer ratios. curve analyzed by kinetics, showing for up 48 h, followed Fickian mechanism, which shown diffusion index value obtained from Korsmeyer-Peppas equation.

Language: Английский

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The Effect of Dual Bioactive Compounds Artemisinin and Metformin Co-loaded in PLGA-PEG Nano-particles on Breast Cancer Cell lines: Potential Apoptotic and Anti-proliferative Action

Applied Biochemistry and Biotechnology, Journal Year: 2022, Volume and Issue: 194(10), P. 4930 - 4945

Published: June 8, 2022

Language: Английский

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Multitargeted molecular docking and dynamics simulation of thymol-based chalcones against cancer protein markers: Synthesis, characterization, and computational study

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1317, P. 139116 - 139116

Published: June 27, 2024

Language: Английский

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Thymol-1,2,3-triazole derivatives: Network Pharmacology, Molecular Simulations and Synthesis Targeting Breast Cancer

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: unknown, P. 140060 - 140060

Published: Sept. 1, 2024

Language: Английский

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Navigating the Synthesis of Quinoline Hybrid Molecules as Promising Anticancer Agents

ChemistrySelect, Journal Year: 2020, Volume and Issue: 5(33), P. 10187 - 10199

Published: Sept. 1, 2020

Abstract The emergence of drug resistance and low specificity with side effects are the significant challenges in pharmaceutical sectors for control cancer nowadays. Notwithstanding, this is an imperative prerequisite to develop novel anticancer agents through mainstream medicinal chemistry approaches. intriguing quinoline its derivatives have demonstrated as building blocks locating new promising agents. Consequently, moiety addition suitable congeners would offer a strategy development potential candidates. This present review article summarizes recent advances (2018‐2020) hybrids their activity. mechanism action plausible structure‐activity relationship discussed.

Language: Английский

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Antimalarial and anticancer properties of artesunate and other artemisinins: current development

Monatshefte für Chemie - Chemical Monthly, Journal Year: 2021, Volume and Issue: 152(4), P. 387 - 400

Published: March 30, 2021

Language: Английский

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Cinnamic acid hybrids as anticancer agents: A mini‐review

Archiv der Pharmazie, Journal Year: 2022, Volume and Issue: 355(7)

Published: April 14, 2022

Abstract Cancer, as a long‐lasting and dramatic disease, affects almost one‐third of human beings globally. Chemotherapeutics play an important role in cancer treatment, but multidrug resistance severe adverse effects have already become the main causes failure tumor chemotherapy. Therefore, it is urgent need to develop novel chemotherapeutics. Cinnamic acid contains ubiquitous α,β‐unsaturated moiety presenting potential therapeutic treatment these derivatives could act on cells by diverse mechanisms action. Accordingly, cinnamic are critical scaffolds discovering anticancer agents. This review provides comprehensive overview hybrids The structure–activity relationship, well action, also discussed, covering articles published from 2012 2021.

Language: Английский

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