Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(18), P. 5232 - 5277
Published: Jan. 1, 2024
This
review
describes
recent
advances
in
the
generation
of
aryl
radicals
using
light
and
electricity.
Such
modern
techniques
allow
for
efficient
energy
resource
utilization,
thus
providing
more
sustainable
radical
arylation
methods.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(5), P. 2441 - 2511
Published: Feb. 21, 2024
Boron-containing
compounds
(BCC)
have
emerged
as
important
pharmacophores.
To
date,
five
BCC
drugs
(including
boronic
acids
and
boroles)
been
approved
by
the
FDA
for
treatment
of
cancer,
infections,
atopic
dermatitis,
while
some
natural
are
included
in
dietary
supplements.
Boron's
Lewis
acidity
facilitates
a
mechanism
action
via
formation
reversible
covalent
bonds
within
active
site
target
proteins.
Boron
has
also
employed
development
fluorophores,
such
BODIPY
imaging,
carboranes
that
potential
neutron
capture
therapy
agents
well
novel
diagnostics
therapy.
The
utility
synthetic
become
multifaceted,
breadth
their
applications
continues
to
expand.
This
review
covers
many
uses
targets
boron
medicinal
chemistry.
Pharmaceuticals,
Journal Year:
2022,
Volume and Issue:
15(3), P. 264 - 264
Published: Feb. 22, 2022
In
this
review,
the
history
of
boron's
early
use
in
drugs,
and
boron
functional
groups
medicinal
chemistry
applications
are
discussed.
This
includes
diazaborines,
boronic
acids,
benzoxaboroles,
clusters,
carboranes.
Furthermore,
critical
developments
from
these
highlighted
along
with
recent
developments,
which
exemplify
potential
prospects.
Lastly,
application
form
a
prodrug,
softdrug,
as
nanocarrier
discussed
to
showcase
emergence
into
new
exciting
fields.
Overall,
we
emphasize
evolution
organoboron
therapeutic
agents
privileged
structures
outline
impact
that
has
had
on
drug
discovery
development.
European Journal of Organic Chemistry,
Journal Year:
2021,
Volume and Issue:
2021(47), P. 6478 - 6510
Published: Sept. 8, 2021
Abstract
Current
medicinal
chemistry
relies
heavily
on
the
quality
of
building
blocks,
i.
e.
reagents
used
to
introduce
chemical
diversity
into
target
molecules.
The
last
decade
witnessed
an
emergence
many
novel
(or
well‐overlooked
old)
chemotypes
for
drug
discovery,
which
is
related
adapting
new
synthetic
methodologies,
designing
sp
3
‐enriched
bioisosteres,
paying
attention
previously
underrated
even
unwanted)
structural
motifs,
or
combination
thereof.
In
this
review
with
532
references,
a
survey
selected
that
emerged
recently
in
provided,
focus
synthesis
corresponding
blocks.
Thus,
saturated
(hetero)aliphatic
boronates,
sulfonyl
fluorides,
sulfinates,
non‐classical
benzene
isosteres,
bicyclic
morpholine/piperidine/piperazine
analogs,
as
well
gem
‐difluorinated
cycloalkanes
(as
example
emerging
fluorinated
motifs)
are
discussed.
Cancers,
Journal Year:
2021,
Volume and Issue:
14(1), P. 87 - 87
Published: Dec. 24, 2021
Hematological
malignancies,
also
referred
to
as
blood
cancers,
are
a
group
of
diseases
involving
abnormal
cell
growth
and
persisting
in
the
blood,
lymph
nodes,
or
bone
marrow.
The
development
new
targeted
therapies
including
small
molecule
inhibitors,
monoclonal
antibodies,
bispecific
T
engagers,
antibody-drug
conjugates,
recombinant
immunotoxins,
and,
finally,
Chimeric
Antigen
Receptor
(CAR-T)
cells
has
improved
clinical
outcomes
for
cancers.
In
this
review,
we
summarized
52
drugs
that
were
divided
into
macromolecule
agents,
approved
by
Food
Drug
Administration
(FDA)
period
between
2011
2021
treatment
hematological
malignancies.
Forty
them
have
been
European
Medicines
Agency
(EMA).
We
analyzed
FDA-approved
investigating
both
their
structures
mechanisms
action.
It
should
be
emphasized
number
was
significantly
higher
(46
drugs)
than
chemotherapy
agents
(6
drugs).
highlight
recent
advances
design
used
treat
which
make
more
effective
less
toxic.
Chemistry - A European Journal,
Journal Year:
2021,
Volume and Issue:
27(62), P. 15277 - 15326
Published: Sept. 9, 2021
Abstract
This
review
discusses
recent
advances
in
the
chemistry
of
saturated
boronic
acids,
boronates,
and
trifluoroborates.
Applications
title
compounds
design
boron‐containing
drugs
are
surveyed,
with
special
emphasis
on
α‐amino
derivatives.
A
general
overview
as
modern
tools
to
construct
C(sp
3
)−C
)‐heteroatom
bonds
is
given,
including
developments
Suzuki‐Miyaura
Chan‐Lam
cross‐couplings,
single‐electron‐transfer
processes
metallo‐
organocatalytic
photoredox
reactions,
transformations
boron
“ate”
complexes.
Finally,
an
attempt
summarize
current
state
art
synthesis
trifluoroborates
made,
a
brief
mention
“classical”
methods
(transmetallation
organolithium/magnesium
reagents
species,
anti‐Markovnikov
hydroboration
alkenes,
modification
alkenyl
compounds)
focus
methodologies
(boronation
alkyl
(pseudo)halides,
derivatives
carboxylic
alcohols,
primary
amines,
boronative
C−H
activation,
novel
approaches
alkene
hydroboration,
1,2‐metallate‐type
rearrangements).
Proceedings of the National Academy of Sciences,
Journal Year:
2021,
Volume and Issue:
118(34)
Published: Aug. 17, 2021
Significance
Boronic
acids
are
one
of
the
most
useful
functional
groups
in
organic
chemistry
and
can
be
used
as
intermediates
synthesis
or
key
motifs
medicines.
This
work
describes
an
extremely
simple
economical
way
to
use
electrochemistry
convert
carboxylic
acids,
through
intermediacy
redox-active
esters,
boronic
acids.
The
scope
this
reaction
is
broad,
mechanism
has
been
thoroughly
studied,
it
easily
scaled
up.
Finally,
application
a
complex
polycyclopropane
natural
product
demonstrated.