Microwave-Assisted Green Synthesis, In Silico Study, and Plant Growth Stimulant Activity of Novel 3-(2-Arylidenehydrazinyl)-6-chloropyridazines

Russian Journal of General Chemistry, Journal Year: 2025, Volume and Issue: 95(3), P. 704 - 714

Published: March 1, 2025

Language: Английский

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A concise and focused overview upon arylglyoxal monohydrates-based one-pot multi-component synthesis of fascinating potentially biologically active pyridazines

Journal of Molecular Structure, Journal Year: 2021, Volume and Issue: 1251, P. 131742 - 131742

Published: Oct. 19, 2021

Language: Английский

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N,N,N’,N’-Tetramethylethylenediamine-Enabled Photoredox-Catalyzed C–H Methylation of N-Heteroarenes

The Journal of Organic Chemistry, Journal Year: 2021, Volume and Issue: 86(17), P. 11905 - 11914

Published: Aug. 3, 2021

Aiming at the valuable methylation process, readily available and inexpensive N,N,N',N'-tetramethylethylenediamine (TMEDA) was first identified as a new methyl source in photoredox-catalyzed transformation this work. By virtue of simple methylating reagent, facile practical protocol for direct C-H N-heteroarenes developed, featuring mild reaction conditions, broad substrate scope, scalability. Mechanistic studies disclosed that sequential photoredox, base-assisted proton shift, fragmentation, tautomerization process essentially involved.

Language: Английский

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Bacterial Hydrazine Biosynthetic Pathways Featuring Cupin/Methionyl tRNA Synthetase‐like Enzymes

ChemBioChem, Journal Year: 2024, Volume and Issue: 25(9)

Published: March 9, 2024

Nitrogen-Nitrogen (N-N) bond-containing functional groups in natural products and synthetic drugs play significant roles exerting biological activities. The mechanisms of N-N bond formation organic molecules have garnered increasing attention over the decades. Recent advances illuminated various enzymatic nonenzymatic strategies, our understanding construction is rapidly expanding. A group didomain proteins with zinc-binding cupin/methionyl-tRNA synthetase (MetRS)-like domains, also known as hydrazine synthetases, generates amino acid-based hydrazines, which serve key biosynthetic precursors diverse functionalities such hydrazone, diazo, triazene, pyrazole, pyridazinone groups. In this review, we summarize current knowledge on pathways employing unique bond-forming machinery.

Language: Английский

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Synthesis and biological evaluation of novel benzo[a]pyridazino[3,4-c]phenazine derivatives

Bioorganic & Medicinal Chemistry Letters, Journal Year: 2021, Volume and Issue: 43, P. 128054 - 128054

Published: April 22, 2021

Language: Английский

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