Advanced Synthesis & Catalysis,
Journal Year:
2023,
Volume and Issue:
365(18), P. 3063 - 3068
Published: March 15, 2023
Abstract
We
presented
a
cascade
transformation
of
N
,
‐diallylamines
and
fluoroalkyl
iodides
into
various
functionalized
fluoroalkylated
pyrrolidines
through
visible
light‐induced
synthetic
process
in
the
solvent‐free
conditions.
In
this
reaction
system,
substrate
N,
‐diallylamine
acted
both
as
base
electron
donor.
further
demonstrated
practicality
protocol
by
direct
modification
amino
acids
pharmaceutical
molecules.
ChemistrySelect,
Journal Year:
2025,
Volume and Issue:
10(3)
Published: Jan. 1, 2025
Abstract
An
efficient
method
offering
high
convenience
and
sustainability,
showcasing
the
potential
for
green
synthesis
strategies
has
been
developed.
The
protocol
presents
a
straightforward,
environmentally
friendly
approach
construction
of
substituted
3,4‐dihydro‐2
H
pyrroles
in
an
aqueous
ethanol
that
describes
one‐pot
multistep
reaction
sequence,
initiated
with
Claisen–Schmidt
Condensation,
followed
by
Michael
addition
nitro
methane
to
chalcone,
next
line
being
reduction
intramolecular
cyclization
steps
yield
desired
product
moderate
higher
yields.
Underscoring
effectiveness
biological
activities
also
evaluated
compounds.
Preliminary
studies
indicating
promising
antibacterial
antifungal
properties,
make
these
compounds
significant
further
pharmaceutical
development.
use
as
solvent
pyrroline
process
underscores
importance
solvents,
significantly
reducing
environmental
impact
aligning
principles
sustainable
chemistry.
synthetic
strategy
combined
notable
demonstrates
dual
benefit
this
research,
contributing
both
field
chemistry
therapeutic
drug
discovery.
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 21, 2025
Ring
contraction
in
skeletal
reorganization
strategies
is
one
of
the
most
intriguing
yet
surprisingly
challenging
transformations.
Herein,
we
report
for
first
time
a
ring
tandem
sulfonation
between
saturated
six-membered
N-heterocyclic
nitroxides
and
sulfonyl
hydrazides
to
access
sulfonated
pyrrolidine
derivatives
by
an
electrochemical
redox
cascade
under
redox-neutral
metal-free
conditions,
which
unavailable
via
conventional
synthetic
approaches.
This
benign
approach
has
been
further
demonstrated
gram-scale
preparation
pharmaceutical
molecule
synthesis
mild
conditions.
Organic Chemistry Frontiers,
Journal Year:
2022,
Volume and Issue:
9(21), P. 5955 - 5961
Published: Jan. 1, 2022
We
reported
an
electrocatalytic
direct
C3-hydroxyalkylation
of
quinoxalin-2(1
H
)-ones
to
construct
3-hydroxyalkylquinoxalin-2(1
)-one
derivatives,
which
uses
unprotected
and
aliphatic
aldehydes
as
substrates.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(4), P. 2494 - 2504
Published: Feb. 7, 2024
We
report
the
atom-economic
and
sustainable
synthesis
of
biologically
important
3,4-dihydro-2H-1,2,4-benzothiadiazine-1,1-dioxide
(DHBD)
derivatives
from
readily
available
aromatic
primary
alcohols
2-aminobenzenesulfonamide
catalyzed
by
nickel(II)-N∧N∧S
pincer-type
complexes.
The
synthesized
nickel
complexes
have
been
well-studied
elemental
spectroscopic
(FT-IR,
NMR,
HRMS)
analyses.
solid-state
molecular
structure
complex
2
has
authenticated
a
single-crystal
X-ray
diffraction
study.
Furthermore,
series
(24
examples)
utilizing
3
mol
%
Ni(II)
catalyst
through
acceptorless
dehydrogenative
coupling
benzyl
with
benzenesulfonamide.
Gratifyingly,
catalytic
protocol
is
highly
selective
yield
up
to
93%
produces
eco-friendly
water/hydrogen
gas
as
byproducts.
control
experiments
plausible
mechanistic
investigations
indicate
that
in
situ
generated
aldehyde
benzenesulfonamide
leads
desired
product.
In
addition,
large-scale
one
thiadiazine
unveils
synthetic
usefulness
current
methodology.
ChemistrySelect,
Journal Year:
2023,
Volume and Issue:
8(16)
Published: April 24, 2023
Abstract
Azetidine
substituent
group
has
a
wide
range
of
application
in
organic
chemistry
and
medical
field.
In
this
study,
novel
azetidine
derivative
its
reaction
mechanism
been
reported.
Using
quantum
chemical
method
spectroscopic
analysis
other
parameters
such
as
electronic
thermodynamic
properties
were
studied
to
understand
the
physical
well
behavior
reported
compound.
Additionally,
study
antiviral
activity,
molecular
docking
studies
carried
out
against
Hepatitis
virus
C
(HCV)
NS5B
genotype
Norovirus
target
protein.
order
validate
results
dynamic
(MD)
simulation
Molecular
Mechanics‐Poisson‐Boltzmann
Surface
Area
(MM‐PBSA)
calculated
at
90
ns.
The
RMSD
was
obtained
within
0.75
Å
1.5
binding
energies
(ΔG
bind
)
for
two
complexes
found
be
−18.34
kJ/mol
−16.10
each
respective
targets.It
that
compound
can
act
potential
inhibitor
HCVand
Norovirus.
European Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
27(4)
Published: Dec. 6, 2023
Abstract
Isatin,
also
known
as
indoline‐2,3‐dione,
is
a
fused,
N
‐heterocyclic
aromatic
compound
first
isolated
and
purified
in
1841.
Since
then,
isatin
its
derivatives
emerged
hot
research
topic
for
the
scientific
community.
The
number
of
publications
on
justifies
their
popularity.
Researchers
explored
isatins
potential
candidates
multidisciplinary
areas,
including
medicinal
chemistry,
synthetic
organic
polymer
science.
Synthetic
chemists’
perspective
tailoring
family
members
led
to
more
efficient
synthesis
strategies
which
ring‐opening
reactions
were
particularly
significant
due
product's
importance.
Our
investigation
aims
group
different
types
cascade
ring
expansion
synthesise
fused
heterocyclic
compounds
such
quinolines,
quinazolinones,
acridines,
acridones,
few
spiro
compounds,
all
highlight
an
inevitable
role
field
chemistry.
