SNPs-Panel Polymorphism Variations in GHRL and GHSR Genes Are Not Associated with Prostate Cancer DOI Creative Commons

Nesrine Merabet,

Nicolás Ramoz, Amel Boulmaiz

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(12), P. 3276 - 3276

Published: Dec. 11, 2023

Prostate cancer (PCa) is a major public health problem worldwide. Recent studies have suggested that ghrelin and its receptor could be involved in the susceptibility to several cancers such as PCa, leading their use an important predictive way for clinical progression prognosis of cancer. However, conflicting results single nucleotide polymorphisms (SNPs) with (GHRL) (GHSR) genes were demonstrated different studies. Thus, present case-control study was undertaken investigate association GHRL GHSR sporadic PCa. A cohort 120 PCa patients 95 healthy subjects enrolled this study. Genotyping six SNPs performed: three tag (rs696217, rs4684677, rs3491141) (rs2922126, rs572169, rs2948694) using TaqMan. The allele genotype distribution, well haplotypes frequencies linked disequilibrium (LD), established. Multifactor dimensionality reduction (MDR) analysis used gene-gene interactions between SNPs. Our showed no significant target (p > 0.05). Nevertheless, are often just markers help identify or delimit specific genomic regions may harbour functional variants rather than causing disease. Furthermore, we found one rs2922126, namely TT genotype, significantly more frequent controls = 0.040). These data suggest genotype. MDR analyses revealed rs2922126 rs572169 combination best model, 81.08% accuracy 0.0001) predicting also precision 98.1% < PR-AUC 1.00. findings provide new insights into influence evidence susceptibility, they guide decision-making prevent overtreatment enhance patients' quality life.

Language: Английский

Ghrelin in Focus: Dissecting Its Critical Roles in Gastrointestinal Pathologies and Therapies DOI Creative Commons
Wei Wu, Lei Zhu, Zhimin Dou

et al.

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(1), P. 948 - 964

Published: Jan. 22, 2024

This review elucidates the critical role of ghrelin, a peptide hormone mainly synthesized in stomach various gastrointestinal (GI) diseases. Ghrelin participates diverse biological functions ranging from appetite regulation to impacting autophagy and apoptosis. In sepsis, it reduces intestinal barrier damage by inhibiting inflammatory responses, enhancing GI blood flow, modulating cellular processes like Notably, bowel disease (IBD), serum ghrelin levels serve as markers for distinguishing between active remission phases, underscoring its potential IBD treatment. gastric cancer, acts an early risk marker, due significant increasing proliferation migration cancer cells, ghrelin–GHS-R axis is poised become target The colorectal (CRC) remains controversial; however, analogs have demonstrated substantial benefits treating cachexia associated with CRC, highlighting therapeutic ghrelin. Nonetheless, complex interplay ghrelin’s protective tumorigenic effects necessitates cautious approach application. post-GI surgery scenarios, could be instrumental recovery reducing complications. article accentuates multifunctionality, shedding light on influence mechanisms, including responses progression, examines surgeries disorders, advocating continued research this evolving field.

Language: Английский

Citations

6
Novel chimeric peptides of endomorphin-2 and the active fragments of ghrelin exhibit blood-brain barrier permeability and central antinociceptive effects with reduced opioid-related side effects DOI

Yongling Liu,

Biao Xu,

Songxia Cheng

et al.

Neuropharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 110324 - 110324

Published: Feb. 1, 2025

Language: Английский

Citations

0
Potential Therapeutic Exploitation of G Protein-Coupled Receptor 120 (GPR120/FFAR4) Signaling in Obesity-Related Metabolic Disorders DOI Open Access
Dariusz Szukiewicz

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2501 - 2501

Published: March 11, 2025

The increasing prevalence of overweight and obesity not only in adults but also among children adolescents has become one the most alarming health problems worldwide. Metabolic disorders accompanying fat accumulation during pathological weight gain induce chronic low-grade inflammation, which, a vicious cycle, increases immune response through pro-inflammatory changes cytokine (adipokine) profile. Obesity decreases life expectancy, largely because obese individuals are at an increased risk many medical complications, often referred to as metabolic syndrome, which refers co-occurrence insulin resistance (IR), impaired glucose tolerance, type 2 diabetes (T2D), atherogenic dyslipidemia, hypertension, premature ischemic heart disease. Metabotropic G protein-coupled receptors (GPCRs) constitute numerous diverse group cell surface transmembrane eukaryotes. Among GPCRs, researchers focusing on connection receptor 120 (GPR120), known free fatty acid 4 (FFAR4), with signaling pathways regulating inflammatory sensitivity. This review presents current state knowledge concerning involvement GPR120 anti-inflammatory signaling. Since both inflammation adipose tissue key obesity, there is rationale for development novel, GPR120-based therapies individuals. main associated introducing this treatment into clinical practice discussed.

Language: Английский

Citations

0
Variants in GHRL, RETN and PLIN1 are associated with obesity, diabetes and metabolic syndrome, and influence food consumption in adults with obesity DOI

Marina Aparecida dos Santos,

Raul Hernandes Bortolin, Álvaro Cerda

et al.

Nutrition Research, Journal Year: 2024, Volume and Issue: 134, P. 13 - 23

Published: Dec. 27, 2024

Language: Английский

Citations

0
SNPs-Panel Polymorphism Variations in GHRL and GHSR Genes Are Not Associated with Prostate Cancer DOI Creative Commons

Nesrine Merabet,

Nicolás Ramoz, Amel Boulmaiz

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(12), P. 3276 - 3276

Published: Dec. 11, 2023

Prostate cancer (PCa) is a major public health problem worldwide. Recent studies have suggested that ghrelin and its receptor could be involved in the susceptibility to several cancers such as PCa, leading their use an important predictive way for clinical progression prognosis of cancer. However, conflicting results single nucleotide polymorphisms (SNPs) with (GHRL) (GHSR) genes were demonstrated different studies. Thus, present case-control study was undertaken investigate association GHRL GHSR sporadic PCa. A cohort 120 PCa patients 95 healthy subjects enrolled this study. Genotyping six SNPs performed: three tag (rs696217, rs4684677, rs3491141) (rs2922126, rs572169, rs2948694) using TaqMan. The allele genotype distribution, well haplotypes frequencies linked disequilibrium (LD), established. Multifactor dimensionality reduction (MDR) analysis used gene-gene interactions between SNPs. Our showed no significant target (p > 0.05). Nevertheless, are often just markers help identify or delimit specific genomic regions may harbour functional variants rather than causing disease. Furthermore, we found one rs2922126, namely TT genotype, significantly more frequent controls = 0.040). These data suggest genotype. MDR analyses revealed rs2922126 rs572169 combination best model, 81.08% accuracy 0.0001) predicting also precision 98.1% < PR-AUC 1.00. findings provide new insights into influence evidence susceptibility, they guide decision-making prevent overtreatment enhance patients' quality life.

Language: Английский

Citations

0