2-Trifluoromethyl-2H-chromene ethers: The dual triumph of anti-inflammation and analgesia with minimal ulcer threat DOI
Nan Cai, Xiang Gao, Ling Jia

et al.

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 154, P. 108050 - 108050

Published: Dec. 13, 2024

Language: Английский

Discovery of novel NSAID hybrids as cPLA2/COX-2 dual inhibitors alleviating rheumatoid arthritis via inhibiting p38 MAPK pathway DOI
Nan Cai, Xiang Gao, Yang Li

et al.

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 267, P. 116176 - 116176

Published: Jan. 24, 2024

Language: Английский

Citations

4
Discovery of novel deoxyvasicinone derivatives with benzenesulfonamide substituents as multifunctional agents against Alzheimer's disease DOI

Shuanghong Dong,

Jucheng Xia,

Fang Wang

et al.

European Journal of Medicinal Chemistry, Journal Year: 2023, Volume and Issue: 264, P. 116013 - 116013

Published: Nov. 30, 2023

Language: Английский

Citations

9
f25, a novel synthetic quinoline derivative, inhibits tongue cancer cell invasion and survival by the PPAR pathway in vitro and vivo DOI
Tuo Liu, Lili Yang, Zeng Li

et al.

Chemico-Biological Interactions, Journal Year: 2024, Volume and Issue: 391, P. 110891 - 110891

Published: Jan. 24, 2024

Language: Английский

Citations

2
Novel trifluoromethyl ketone derivatives as oral cPLA2/COX-2 dual inhibitors for resolution of inflammation in rheumatoid arthritis DOI
Nan Cai, Xiang Gao, Wenjing Li

et al.

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 148, P. 107453 - 107453

Published: May 14, 2024

Language: Английский

Citations

2
Discovery of novel CXCR4 inhibitors for the treatment of inflammation by virtual screening and biological evaluation DOI
Fang Wang, Jie Ma, Lili Yang

et al.

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 275, P. 116605 - 116605

Published: June 15, 2024

Language: Английский

Citations

2
3-(2-Trifluoromethyl-3-aryl-4H-chromen-4-yl)-1H-indoles: Mastering anti-inflammation and analgesia while mitigating gastrointestinal side effects DOI
Nan Cai, Xiang Gao, Ling Jia

et al.

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 153, P. 107805 - 107805

Published: Sept. 5, 2024

Language: Английский

Citations

2
Anti-inflammatory effect of glycyrrhetinic acid in IL-1β-induced SW982 cells and adjuvant-induced arthritis DOI Creative Commons
Yang Song, Xinyu Xing,

Jing Shen

et al.

Heliyon, Journal Year: 2023, Volume and Issue: 9(5), P. e15588 - e15588

Published: April 28, 2023

Influences of Glycyrrhetinic acid on expression inflammatory factors in interleukin (IL)-1β-induced SW982 cells and its anti-inflammatory effects were discussed this study. MTT results showed that (≤80 μmol·L-1) almost has no toxicity cells. The ELISA real-time PCR (10, 20 40 μmol · L-1) can significantly inhibit the such as IL-6, IL-8 matrix metalloproteinase-1 (MMP-1). Western blot analysis remarkably blocked NF-κB signaling pathway vitro. Molecule docking could bind to active site (NLS Polypeptide) p65. Furthermore, observation rat foot swelling proved had a significant therapeutic effect adjuvant-induced arthritis (AIA) rats vivo. Collectively, all these findings suggested might be promising lead compound worthy further pursuit anti-inflammation agent.

Language: Английский

Citations

3
Occurrence of Quinoline in the Environment and Its Advanced Treatment Technologies DOI
Parmita Chawley,

Alok Kumar Suman,

Sheeja Jagadevan

et al.

Energy, environment, and sustainability, Journal Year: 2023, Volume and Issue: unknown, P. 213 - 233

Published: Jan. 1, 2023

Language: Английский

Citations

2
COF‐SO3H‐Catalyzed Synthesis of Pyrazoline‐Pyridine Hybrids with Dual Antioxidant and Anti‐Inflammatory Activity Targeting PDE4B DOI
Nida Khan, Mohd Kamil Hussain, Mohammad Faheem Khan

et al.

Chemistry & Biodiversity, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 11, 2024

Abstract This study explores new anti‐inflammatory agents by synthesizing pyrazoline‐pyridine hybrids with N‐butylsulfonated covalent organic framework (COF‐SO 3 H) as a recyclable catalyst, achieving excellent yields in just one minute. The protocol was successfully scaled up to multi‐gram scale, highlighting its robustness and efficiency, it operates without the need for column chromatography. Among synthesized hybrids, compound 5d , hybrid bearing an indole moiety, emerged potent antioxidant agent. It effectively inhibited PDE4B activation IC 50 value of 99.38 nM, adversely affecting HEK cells. Compound demonstrated dual activity significantly reducing ROS production restoring mitochondrial health LPS‐stimulated A549 cells, while also downregulating IL‐1β NF‐ĸB/p65 expression In silico studies confirmed ’s strong binding PDE4B, stable RMSD RMSF values, indicating potential effective inhibitor. exhibited favorable physicochemical properties, met drug‐likeness criteria, showed low toxicity predicted silico. These findings suggest that has significant therapeutic agent inflammatory diseases due activities.

Language: Английский

Citations

0
2-Trifluoromethyl-2H-chromene ethers: The dual triumph of anti-inflammation and analgesia with minimal ulcer threat DOI
Nan Cai, Xiang Gao, Ling Jia

et al.

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 154, P. 108050 - 108050

Published: Dec. 13, 2024

Language: Английский

Citations

0