Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1312, P. 138450 - 138450
Published: April 30, 2024
Language: Английский
Journal of Molecular Liquids, Journal Year: 2024, Volume and Issue: 403, P. 124887 - 124887
Published: April 30, 2024
Language: Английский
Citations
3
Journal of Applied Biomaterials & Functional Materials, Journal Year: 2024, Volume and Issue: 22
Published: Jan. 1, 2024
Nanofibrous scaffolds have emerged as promising candidates for localized drug delivery systems in the treatment of cutaneous cancers. In this study, we prepared an electrospun nanofibrous scaffold incorporating 5-fluorouracil (5-FU) and etoposide (ETP) chemotherapy targeting melanoma cancer. The was composed polyvinyl alcohol (PVA) chitosan (CS), via electrospinning process loaded with chemotherapeutic agents. We conducted relevant physicochemical characterizations, assessed cytotoxicity, evaluated apoptosis against A375 cells. 5-FU/ETP co-loaded PVA/CS exhibited nanofibers (NFs) average diameter 321 ± 61 nm, defect-free homogenous morphology. FTIR spectroscopy confirmed successful incorporation chemotherapeutics into scaffold. Additionally, demonstrated a hydrophilic surface, proper mechanical strength, high porosity, efficient liquid absorption capacity. Notably, sustained controlled release observed from Furthermore, significantly increased cytotoxicity (95%) (74%) Consequently, holds promise valuable system eradication tumors mitigation adverse reactions associated chemotherapy.
Language: Английский
Citations
3
Journal of Inorganic and Organometallic Polymers and Materials, Journal Year: 2025, Volume and Issue: unknown
Published: March 27, 2025
Language: Английский
Citations
0
Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(4), P. 531 - 531
Published: April 5, 2025
Background: Antidepressants are a class of pharmaceuticals utilized for the management many psychiatric disorders, including depression. A considerable number antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs), have been documented to demonstrate significant anticancer properties in various cancer cell lines. Objectives: The aim this study was evaluate cytotoxic and apoptotic effects escitalopram oxalate (ES) alone combination with etoposide (ET) on ET-resistant A549 (A549/90E) lung cells. Methods: drugs were determined by CCK-8, trypan blue, neutral red assays. Apoptosis observed Annexin V fluorescein isothiocyanate (FITC)/PI mitochondrial membrane potential (ΔΨm) Moreover, drugs, combination, apoptosis-related proteins, caspase-3, PTEN, resistance-related P-gP ELISA. relationship between protein–protein interaction (PPI) network analysis. Results: Our results revealed that ES significantly exerted both wild-type A549/90E cells compared BEAS-2B IC50 values 48.67 51.6 μg/mL obtained ET ES, respectively, at end 24 h incubation applied reciprocally each together 2xIC50 ½ values. statistically evaluated indices (CIs) using Compusyn synergistic effect analysis program. Combination doses an antagonistic as ES. IC50, + caused 18.37%, 55.19%, 57.55% death cells, whereas they 44.9%, 22.4%, 51.94% respectively. In increased levels caspase-3 (p < 0.01) 0.001), while PTEN remained unchanged. resulted increase 0.001) amounts, alongside decrease mechanism induced found be V-FITC ΔΨm Conclusions: Based our findings, induce activities vitro. therapy is considered effective overcome resistance reducing amount
Language: Английский
Citations
0
Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1312, P. 138450 - 138450
Published: April 30, 2024
Language: Английский
Citations
3