N-heterocyclic carbene catalyzed [2 + 3] annulation reaction for the synthesis of trifluoroethyl 3,2′-spirooxindole γ-lactam DOI Creative Commons

Yiru Pu,

Maolin Wang,

Wanrong Tian

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(26), P. 18453 - 18458

Published: Jan. 1, 2024

Asymmetric catalytic processes promoted by N-heterocyclic carbenes (NHCs) hold great potential for the sustainable preparation of chiral molecules. However, catalyzing reactions manipulating reactive intermediates is challenging. We report herein that known NHC-catalyzed [3 + 2] annulation reaction between ketimine and enal can also be turned into a [2 3] highly enantioselective direct synthesis trifluoroethyl 3,2'-spirooxindole γ-lactams (4) through timely catalysis intermediates. DFT calculations revealed this transformation included key step nucleophilic attack Breslow intermediate M2 derived from NHC (2) to unattacked (1). Our study demonstrates it possible tune desired selectivities dynamic catalysts

Language: Английский

Dual targeting of FR+CD44 overexpressing tumors by self-assembled nanoparticles quantitatively conjugating folic acid-hyaluronic acid to the GSH-sensitively modified podophyllotoxin DOI
Chaozheng Zhang, Yao Chen, Yi Y. Zuo

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159276 - 159276

Published: Jan. 1, 2025

Language: Английский

Citations

3
Aptamer-functionalized triptolide with release controllability as a promising targeted therapy against triple-negative breast cancer DOI Creative Commons
Yao Chen, Ji-Rui Yang,

Chuanqi Wang

et al.

Journal of Experimental & Clinical Cancer Research, Journal Year: 2024, Volume and Issue: 43(1)

Published: July 25, 2024

Targeted delivery and precise release of toxins is a prospective strategy for the treatment triple-negative breast cancer (TNBC), yet flexibility to incorporate both properties simultaneously remains tremendously challenging in X-drug conjugate fields. As critical components conjugates, linkers could flourish achieving optimal functionalities. Here, we pioneered pH-hypersensitive tumor-targeting aptamer AS1411-triptolide (AS-TP) achieve smart toxin targeted therapy against TNBC. The multifunctional acetal ester linker AS-TP site-specifically blocked triptolide toxicity, quantitatively sustained targeting, ensured circulating stability. Furthermore, modification endowed with favorable water solubility bioavailability facilitated endocytosis conjugated by TNBC cells nucleolin-dependent manner. integrated superiorities promoted preferential intra-tumor accumulation xenografted mice triggered in-situ weakly acidic tumor microenvironment, manifesting striking anti-TNBC efficacy virtually eliminated toxic effects beyond clinical drugs. This study illustrated therapeutic potential proposed promising concept development nucleic acid-based anticancer

Language: Английский

Citations

12
A novel LD-targeting cysteine-activated fluorescent probe for diagnosis of APAP-induced liver injury and its application in food analysis DOI
Zhiqiang Yang, Xin Kang, Jia Li

et al.

Food Chemistry, Journal Year: 2024, Volume and Issue: 456, P. 140064 - 140064

Published: June 12, 2024

Language: Английский

Citations

10
SRF/SLC31A1 signaling promotes cuproptosis induced by celastrol in NSCLC DOI
Rui Xue,

Chuling Qin,

Lanyu Li

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 148, P. 114165 - 114165

Published: Jan. 27, 2025

Language: Английский

Citations

0
A robust H2O2-responsive AIEgen with multiple-task performance: Achieving food analysis, visualization of dual organelles and diagnosis of liver injury DOI
Lee Jia, Xin Kang,

Nianjia Liu

et al.

Biosensors and Bioelectronics, Journal Year: 2025, Volume and Issue: 276, P. 117276 - 117276

Published: Feb. 16, 2025

Language: Английский

Citations

0
Nano-Phytoconstituents: Recent Advances, Regulatory Insights, Challenges, and Future Horizons DOI
M H Miran Beygi, Fatemeh Oroojalian, Sercan Karav

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106908 - 106908

Published: April 1, 2025

Language: Английский

Citations

0
Silencing of tropomodulin 1 inhibits acute myeloid leukemia cell proliferation and tumor growth by elevating karyopherin alpha 2–mediated autophagy DOI Creative Commons
Xia Yuan, Dan Wang, Huijie Zhao

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 207, P. 107327 - 107327

Published: July 28, 2024

Evidence shows that tropomodulin 1 (TMOD1) is a powerful diagnostic marker in the progression of several cancer types. However, regulatory mechanism TMOD1 tumor still unclear. Here, we showed was highly expressed acute myeloid leukemia (AML) specimens, and TMOD1-silencing inhibited cell proliferation by inducing autophagy AML THP-1 MOLM-13 cells. Mechanistically, C-terminal region directly bound to KPNA2, TMOD1-overexpression promoted KPNA2 ubiquitylation reduced levels. In contrast, increased levels facilitated nuclear transfer then subsequently induced increasing nucleocytoplasmic transport p53 AMPK activation. KPNA2/p53 inhibitors attenuated silencing Silencing also growth elevating KPNA2-mediated nude mice bearing xenografts. Collectively, our data demonstrated could be novel therapeutic target for treatment.

Language: Английский

Citations

3
Hydroxyl-based acid-hypersensitive acetal ester bond: Design, synthesis and the application potential in nanodrugs DOI

Chuanqi Wang,

Hong Xu, Ying Chen

et al.

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 283, P. 117153 - 117153

Published: Dec. 11, 2024

Language: Английский

Citations

3
Responsive ROS‐Augmented Prodrug Hybridization Nanoassemblies for Multidimensionally Synergitic Treatment of Hepatocellular Carcinoma in Cascade Assaults DOI Creative Commons
Ying‐Jie Zeng,

Yuening Cao,

Senmiao Ren

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: May 5, 2025

Abstract The rapid deterioration and progression of hepatocellular carcinoma (HCC) is intimately associated with copper ion overload, integrating the cuproptosis mechanism for treatment HCC presents a promising prospect. Nevertheless, cell death complexity renders efficient removal all cells insufficient solely relying on pathway. Herein, GSH‐responsive prodrug hybridization nanoassembly CA‐4S 2 @ES‐Cu exploited, which targets delivery ions to mitochondria via Elesclomol, contributing mitochondrial dysfunction evoking cuproptosis. Simultaneously, depletes GSH release CA‐4, disrupting microtubule function suppressing proliferation angiogenesis, realize dual attack against ion‐mediated metastasis HCC. Furthermore, both in mouse model synergistically elicit oxidative stress amplify effect activated immunogenetic initiate vigorous antitumor immune response cascade assault modality. Conclusively, multilevel synergistic penetrates limitations single therapy implements multidimensional targeted

Language: Английский

Citations

0
Characterizing the Membrane Assembly of ASGPR Related to Mediated Endocytosis Using TriGalNAc-Probe-Based Super-Resolution Imaging DOI Creative Commons

Junling Chen,

Jiaqi Wang, Binglin Sui

et al.

JACS Au, Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

Language: Английский

Citations

0