Organoselenium compounds beyond antioxidants DOI
Ritu Mamgain, Garima Mishra,

Saumya Kriti

et al.

Future Medicinal Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 23

Published: Dec. 22, 2024

Organoselenium chemistry has become a significant field due to its role in synthesizing numerous biologically active and therapeutic compounds. In early phase, researchers focused on designing organoselenium compounds with antioxidant properties were quite successful. last two decades, synthetic chemists shifted their focus toward synthesis of biological properties, moving beyond traditional properties. The review includes study organo-selenium as anticancer, antimicrobial, antiviral, antidiabetic, antithyroid, anti-inflammatory therapies, contributing disease treatment. This covers the medicinal applications over past 10 years, thus making it valuable resource for chemistry.

Language: Английский

Spiroindoline quinazolinedione derivatives as inhibitors of P-glycoprotein: potential agents for overcoming multidrug resistance in cancer therapy DOI
Fatemeh Moosavi,

Masoumeh Divar,

Soghra Khabnadideh

et al.

Molecular Diversity, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Language: Английский

Citations

1
Optimized ebselen derivatives as novel potent Escherichia coli β-glucuronidase covalent allosteric inhibitors DOI

Ti‐Ti Ying,

Haoqiang Hu,

Xiaowen Wu

et al.

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 117571 - 117571

Published: March 1, 2025

Language: Английский

Citations

0
Selective Synthesis of 3-Selenoindoles via Selenation of Indoles under Catalyst-Free Condition DOI

Dengpeng Xia,

Qi Wu, Zhihua Cai

et al.

Chinese Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: 45(1), P. 349 - 349

Published: Jan. 1, 2025

Language: Английский

Citations

0
Discovery of new tricyclic spiroindole derivatives as potent P-glycoprotein inhibitors for reversing multidrug resistance enabled by a synthetic methodology-based library DOI
Tao Yu, Rong Zeng, Yu Guan

et al.

RSC Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 15(5), P. 1675 - 1685

Published: Jan. 1, 2024

Based on synthetic methodology-based library, a new class of tricyclic spiroindole derivatives as potent P-glycoprotein inhibitors with excellent tumor multidrug resistance reversal activity was discovered.

Language: Английский

Citations

2
Discovery of novel pyrazolo[1,5-a]pyrimidine derivatives as potent reversal agents against ABCB1-mediated multidrug resistance DOI

Xiang-Jing Fu,

Na Li,

Ji Wu

et al.

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 277, P. 116761 - 116761

Published: Aug. 13, 2024

Language: Английский

Citations

2
In‐Silico Design of Novel Indole‐Selenide Derivatives as Potential P‐Glycoprotein Inhibitors Against Multi‐Drug Resistance in MCF‐7/ADR Cells: 2D‐QSAR, Molecular Docking, and Dynamics Simulations DOI Open Access

Abdelmadjid Guendouzi,

Lotfi Belkhırı, Houari Brahim

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(41)

Published: Oct. 28, 2024

Abstract In this work, a set of thirty‐one novel indole‐selenide derivatives ( C1 – C31 ), reported recently as P‐glycoprotein inhibitors against multi‐drug resistance in MCF‐7/ADR cells, have been computationally investigated for the first time by in‐silico approaches, combining 2D‐quantitative structure‐activity relationship based virtual screening (2D‐QSAR‐VS) model, molecular docking, and dynamics simulations. The study aims to design new potent molecules with higher anticancer inhibitory activity than observed in‐vitro assays. 2D‐QSAR model is built using multiple linear regression (MLR) techniques, cross‐validated internal external parameters, applicability domain (AD) analysis, Y‐randomization tests, corroborating Golbreikh Tropsha criteria. Subsequently, was performed on generated database, considering pIC50 values most effective in‐vivo C27 inhibitor. docking simulations were applied selected higher‐scoring ligands showing best interactions PHE643, TYR745, PRO571 amino acids P‐gp receptor (7 A6E), predicting dynamically stable complexes at time‐scale 200 ns. outcomes indicate that shown promising future anti‐cancer therapies, perspective validating studies.

Language: Английский

Citations

1
Indoles as promising Therapeutics: A review of recent drug discovery efforts DOI

Naik Jui Pravin,

Rohini S. Kavalapure, Shankar G. Alegaon

et al.

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 154, P. 108092 - 108092

Published: Dec. 25, 2024

Language: Английский

Citations

1
Selenium(II)‐Nitrogen Exchange (SeNEx) Chemistry: A Good Chemistry Suitable for Nanomole‐Scale Parallel Synthesis, DNA‐encoded Library Synthesis, and Bioconjugation DOI
Wei Hou,

Shaoneng Hou,

Yuang Gu

et al.

ChemBioChem, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 9, 2024

The continuous development of click reactions with new connecting linkage is crucial for advancing the frontiers chemistry. Selenium-nitrogen exchange (SeNEx) chemistry, a versatile chemistry in represents an all-encompassing term nucleophilic substitution events that replace nitrogen at electrophilic selenium(II) center, enabling flexible and efficient assembly linkages around Se(II) core. Several SeNEx chemistries have been developed inspired by biochemical reaction between Ebselen cysteine residue, demonstrated significant potential on-plate nanomole-scale parallel synthesis, selenium-containing DNA-encoded library (SeDEL) as well peptide protein bioconjugation. This concept aims to present origins, advancements, applications selenium(II)-nitrogen while also outlining directions future research this field.

Language: Английский

Citations

0
Organoselenium compounds beyond antioxidants DOI
Ritu Mamgain, Garima Mishra,

Saumya Kriti

et al.

Future Medicinal Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 23

Published: Dec. 22, 2024

Organoselenium chemistry has become a significant field due to its role in synthesizing numerous biologically active and therapeutic compounds. In early phase, researchers focused on designing organoselenium compounds with antioxidant properties were quite successful. last two decades, synthetic chemists shifted their focus toward synthesis of biological properties, moving beyond traditional properties. The review includes study organo-selenium as anticancer, antimicrobial, antiviral, antidiabetic, antithyroid, anti-inflammatory therapies, contributing disease treatment. This covers the medicinal applications over past 10 years, thus making it valuable resource for chemistry.

Language: Английский

Citations

0