Isopropoxy benzene guanidine: A promising new weapon against enterococcal infections DOI Creative Commons

Jianxin Hu,

Yongxiang Zhang, Jinyu Yang

et al.

Journal of Integrative Agriculture, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Membrane-Targeting Amphiphilic Honokiol Derivatives Containing an Oxazole Moiety as Potential Antibacterials against Methicillin-Resistant Staphylococcus aureus DOI
Ruige Yang,

Liping Cui,

Shengnan Xu

et al.

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 11, 2024

Infections with methicillin-resistant

Language: Английский

Citations

9
Plant Flavonoids with Antimicrobial Activity against Methicillin-Resistant Staphylococcus aureus (MRSA) DOI
Shengnan Xu,

Ayue Kang,

Yue Tian

et al.

ACS Infectious Diseases, Journal Year: 2024, Volume and Issue: 10(9), P. 3086 - 3097

Published: June 4, 2024

Methicillin-resistant

Language: Английский

Citations

8
Unlocking the Antibacterial Potential of Naphthalimide–Coumarins to Overcome Drug Resistance with Antibiofilm and Membrane Disruption Ability against Escherichia coli DOI
Saurabh Gupta, Vijay Luxami, Kamaldeep Paul

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Resistance by bacteria to available antibiotics is a threat human health, which demands the development of new antibacterial agents. Considering prevailing conditions, we have developed library naphthalimide-coumarin moieties as broad-spectrum agents fight against awful drug resistance. Preliminary studies indicate that compounds

Language: Английский

Citations

1
Development of amphipathic derivatives of thymol and carvacrol as potent broad-spectrum antibacterial agents DOI
Hongbo Dong,

Yuanwei You,

Na Wang

et al.

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 276, P. 116716 - 116716

Published: July 26, 2024

Language: Английский

Citations

6
Quaternized antimicrobial peptide mimics based on harmane as potent anti-MRSA agents by multi-target mechanism covering cell wall, cell membrane and intracellular targets DOI
Jinyi Liu,

Yidan Cao,

Chenggong Xu

et al.

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 276, P. 116657 - 116657

Published: July 4, 2024

Language: Английский

Citations

5
Identification of CH2-linked quinolone-aminopyrimidine hybrids as potent anti-MRSA agents: Low resistance potential and lack of cross-resistance with fluoroquinolone antibiotics DOI

Hongxue Dai,

Yue Hu, Yiwen Zhang

et al.

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 271, P. 116399 - 116399

Published: April 11, 2024

Language: Английский

Citations

4
From Natural Products to Small Molecules: Recent Advancements in Anti-MRSA Therapeutics DOI Creative Commons
Jack W. Smith, A. LeBlanc, William M. Wuest

et al.

ACS Medicinal Chemistry Letters, Journal Year: 2025, Volume and Issue: 16(4), P. 542 - 551

Published: March 14, 2025

The urgent need for unique small molecules to treat increasing resistance in gram-positive pathogens, particularly methicillin-resistant Staphylococcus aureus, has motivated several creative research endeavors over the past decade. Recent advances have been inspired by natural products such as pleuromutilin, discovered high-throughput screens, or repurposed approved drugs like sorafenib. This microperspective spotlights bioactive compounds, ranging from molecule scaffolds, that reported recent literature, highlighting their mechanisms of action, structure-activity relationships, and future potential.

Language: Английский

Citations

0
Preparation and biological evaluation of coumarin amide derivatives bearing fluorine as potential fungicides and anticancer agents DOI Creative Commons
Xin Xiang, Yafang Chen,

Lang Wu

et al.

Arabian Journal of Chemistry, Journal Year: 2024, Volume and Issue: 17(9), P. 105872 - 105872

Published: June 12, 2024

In order to find new potential fungicides and anticancer agents, a series of coumarin amide derivatives bearing fluorine were synthesized characterized spectroscopically. Compounds A6, B11, C2 C7 confirmed by X-ray diffraction further. The antifungal bioassays against five typical pathogenic fungi showed that compound C5 exhibited more remarkable fungicidal activities Alternaria alternata (EC50 = 11.5 μg/mL), Colletotrichum gloeosporioides 18.0 Pyricularia grisea 33.8 surpassing kresoxim-methyl. Molecular docking result indicated displayed high binding affinity chitinase, which plays crucial role in degradation remodeling fungal cell walls. addition, the three cancer cells demonstrated A4 excellent growth inhibitory effect Hela with IC50 value 8.13 μM, low cytotoxicity human normal BEAS-2B. Flow cytometric analysis further significantly arrested cycle at S phase trigger apoptosis. With above interesting biological profile, these could be used as anfungicides candidates.

Language: Английский

Citations

2
Targeting bacterial phospholipids and their synthesis pathways for antibiotic discovery DOI
Meirong Song, Shang Chen, Wenhan Lin

et al.

Progress in Lipid Research, Journal Year: 2024, Volume and Issue: unknown, P. 101307 - 101307

Published: Nov. 1, 2024

Language: Английский

Citations

2
Novel Steroidal β-Carboline Derivatives as Promising Antibacterial Candidates against Methicillin-Resistant Staphylococcus aureus DOI
Haibo Huo,

Wenjia Dan,

Lirong Qin

et al.

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 283, P. 117187 - 117187

Published: Dec. 19, 2024

Language: Английский

Citations

2