Computational Advancements and In Vitro Evaluation in Pre-clinical Anticancer Drug Discovery and Development DOI
Utid Suriya,

Boonyarut Ladda,

Bodee Nutho

et al.

Interdisciplinary cancer research, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

Ferroptosis in Cancer Therapy: Mechanisms, Small Molecule Inducers, and Novel Approaches DOI Creative Commons

YiLin Luo,

Xin Yue Bai,

L.J. Zhang

et al.

Drug Design Development and Therapy, Journal Year: 2024, Volume and Issue: Volume 18, P. 2485 - 2529

Published: June 1, 2024

Abstract: Ferroptosis, a unique form of programmed cell death, is initiated by an excess iron accumulation and lipid peroxidation-induced damage. There growing body evidence indicating that ferroptosis plays critical role in the advancement tumors. The increased metabolic activity higher levels tumor cells make them particularly vulnerable to ferroptosis. As result, targeted induction becoming increasingly promising approach for cancer treatment. This review offers overview regulatory mechanisms ferroptosis, delves into mechanism action traditional small molecule inducers their effects on various In addition, latest progress inducing using new means such as proteolysis-targeting chimeras (PROTACs), photodynamic therapy (PDT), sonodynamic (SDT) nanomaterials summarized. Finally, this discusses challenges opportunities development ferroptosis-inducing agents, focusing discovering targets, improving selectivity, reducing toxic side effects. Keywords: inducers, molecules, PROTACs, PDT, SDT,

Language: Английский

Citations

9
Small molecule inhibitors targeting heat shock protein 90: An updated review DOI
Yulong Li, Jinyun Dong, Jiang‐Jiang Qin

et al.

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 275, P. 116562 - 116562

Published: June 4, 2024

Language: Английский

Citations

8
Heat Shock Protein 90 Interactome-Mediated Proteolysis Targeting Chimera (HIM-PROTAC) Degrading Glutathione Peroxidase 4 to Trigger Ferroptosis DOI
Jinyun Dong,

Furong Ma,

Mao-Hua Cai

et al.

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 67(18), P. 16712 - 16736

Published: Sept. 4, 2024

Targeted protein degradation (TPD) is an emerging therapeutic paradigm aimed at eliminating the disease-causing with aberrant expression. Herein, we report a new approach to inducing intracellular glutathione peroxidase 4 (GPX4) trigger ferroptosis by bridging target heat shock 90 (HSP90), termed HSP90 interactome-mediated proteolysis targeting chimera (HIM-PROTAC). Different series of HIM-PROTACs were synthesized and evaluated, two them, GDCNF-2/GDCNF-11 potently induced via HSP90-mediated ubiquitin-proteasomal GPX4 in HT-1080 cells DC

Language: Английский

Citations

6
Discovery of novel JQ1 derivatives as dual ferroptosis and apoptosis inducers for the treatment of triple-negative breast cancer DOI
Ran Ding, Lijie Tang, Daniel Zeng

et al.

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 286, P. 117275 - 117275

Published: Jan. 11, 2025

Language: Английский

Citations

0
An updated review on the role of small molecule in mediating protein degradation DOI

Zumei Wu,

Yulong Li, Jinyun Dong

et al.

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 287, P. 117370 - 117370

Published: Feb. 4, 2025

Language: Английский

Citations

0
Examining the Prognostic and Clinicopathological Significance of GPX4 in Human Cancers: A Meta-analysis DOI
Hao Wu,

Xiting Liao,

W. Huang

et al.

Free Radical Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 11

Published: March 4, 2025

Elevated levels of the enzyme GPX4 have been detected in tumor tissues, which may play a role cancer progression. We did meta-analysis eight studies encompassing 1180 individuals to evaluate importance cancer, particularly terms prognosis and clinicopathological characteristics. Research results indicate that higher were linked worse overall survival (OS) (HR = 1.47 [95%CI 1.18-1.76], p < .001). lymph node invasion (OR.69 [95% CI.44-1.10], =.12), metastasis (OR 1.58 CI.97-2.55], =.06, <.0001), advanced clinical stage III-IV (OR.82 CI.70-.96], =.001). A sensitivity study revealed general findings constant across all impact intensity. The this suggest increased are not only correlated with reduced rates for patients tumors but it also offers valuable insights regarding traits malignancy metastasis. Based on these connections, has potential serve as biomarker detection, prognosis, targeted therapy.

Language: Английский

Citations

0
Synthesis and evaluation of novel tetrahydroisoquinoline-benzo[h]chromen-4-one conjugates as dual ABCB1/CYP1B1 inhibitors for overcoming MDR in cancer DOI
Jinyun Dong, Yulong Li,

Zhiyuan Jin

et al.

Bioorganic & Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 114, P. 117944 - 117944

Published: Oct. 11, 2024

Language: Английский

Citations

3
Ferroptosis in hepatocellular carcinoma: Mechanisms and therapeutic implications DOI Open Access

Shanjie Tu,

Yisheng Zou,

Meiqi Yang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 182, P. 117769 - 117769

Published: Dec. 16, 2024

Language: Английский

Citations

2
A prospective therapeutic strategy: GPX4-targeted ferroptosis mediators DOI

Jia-Yu Qian,

Chao-Yuan Lou,

Yili Chen

et al.

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 281, P. 117015 - 117015

Published: Oct. 30, 2024

Language: Английский

Citations

1
Computational Advancements and In Vitro Evaluation in Pre-clinical Anticancer Drug Discovery and Development DOI
Utid Suriya,

Boonyarut Ladda,

Bodee Nutho

et al.

Interdisciplinary cancer research, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

Citations

0