Tuning In Vitro Cytotoxicity in Diruthenium(I) bis‐Cyclopentadienyl Complexes

Applied Organometallic Chemistry, Journal Year: 2025, Volume and Issue: 39(5)

Published: April 3, 2025

ABSTRACT A series of diruthenium(I) aminocarbyne complexes general formula [Ru 2 Cp (CO)(L)(μ‐CO){μ‐CNMe (Cy)}] + (L = NH 3 , [ ] ; Py, PPh 4 DMSO, 5 thiourea, 6 ) and (μ‐H)(CO) {μ‐CNMe (Cy)}], 7 were prepared from the tricarbonyl precursor (CO) (μ‐CO){μ‐CNMe . The reactivity vinyliminium complex (CO)(μ‐CO){μ‐η 1 :η ‐C (Ph)CHCNMe was also investigated, providing access to piano stool Ru (II) cyclopentadienyl with a five‐membered metallacyclic ligand containing sulfur. new compounds characterized by IR multinuclear NMR spectroscopy X‐ray diffraction (in three cases). solubility in water, lipophilicity, speciation – ]CF SO water/DMSO cell culture medium are regulated different monodentate ligands. Subsequently, tested vitro against human ovarian cancer cells (A2780 A2780cis) embryonic kidney (HEK293), demonstrating moderate potent cytotoxicity.

Language: Английский

Synthesis and crystallographic investigation of dicobalt tetrahedrane complexes ligated by 2-butyne-1,4-diol. In silico evaluation of their efficiency as anticancer metallodrugs

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: unknown, P. 140108 - 140108

Published: Sept. 1, 2024

Language: Английский

Synthesis and Crystallographic Investigation of a Series of Dicobalt Tetrahedrane Complexes Ligated by 2-Butyne-1,4-Diol. In Silico Evaluation of Their Efficiency as Anticancer Metallodrugs by Docking Studies

Published: Jan. 1, 2024

Language: Английский