2‐Chloroquinolinyl‐thiazolidine‐2,4‐dione Hybrids as Potential α‐Amylase Inhibitors: Synthesis, Biological Evaluations, and In Silico Studies DOI

Sheetal B. Karmur,

Monil P. Dholariya, Anil S. Patel

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(39)

Published: Oct. 1, 2024

Abstract Recently, molecular hybridization strategy has paved a way to develop novel lead compounds for the α‐amylase targeted antidiabetic therapy. In this study, we disclosed series of new hybrids thiazolidine‐2,4‐diones with 2‐chloroquinoline‐3‐yl moiety as potential agents. The structures all synthesized ( 15a–n ) were confirmed by spectroscopic studies (FT‐IR, ESI‐MS, 1 H, 13 C NMR, and elemental analysis). When in vitro evaluation these agents was carried out dose‐dependent manner, it revealed that several 15f– h , 15j, 15n endowed significant activities exhibited more than 50% inhibition at dose 50 µg/mL. Particularly, hybrid found be potent acarbose 95% IC 5.00 ± 0.18 µM under given conditions. Further, demonstrated bearing 2‐chloroquinolinyl thiazolidin‐2,4‐dione scaffolds functionalized 3‐OMe 4‐OH groups not only able effectively bind receptor site best docking score (−9.644 kcal/mol) but also possessed drug‐likenesses properties no violations Lipinski rule. Overall, study discovered 2‐chloroquinolinyl‐thiazolidine‐2,4‐diones inhibitors compound promising its further development agent.

Language: Английский

Synthesis, biological evaluation, and molecular docking of ent -sauchinone-based amide derivatives with potential anti-invasion and anti-migration activities DOI
Yanjun He, Di Xiao,

Qi‐Zhe Gong

et al.

Natural Product Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 8

Published: Feb. 3, 2025

Ent-Sauchinone is a bioactive lignan isolated from Saururus chinensis (Lour.) Baill could suppress the migration and invasion of hepatocellular carcinoma (HCC) cells. The study involves structural modification ent-sauchinone to augment its inhibitory effect on HCC progression investigate mechanisms involved. In this study, series based amide derivatives were synthesised anticancer activities evaluated against two hepatoma cell lines. Among them, compound 3 exhibited excellent resistance by reversing epithelial-mesenchymal transition (EMT) inhibiting phosphorylation signal transducer activator transcription (STAT3) expression matrix metalloproteinases (MMPs). Molecular docking results indicate that may exert liver cancer acting DNA-binding domain STAT3. These suggested be potential agent, especially for metastatic therapy.

Language: Английский

Citations

1
Expression of PPAR-γ TF by newly synthesized thiazolidine-2,4-diones to manage glycemic control: Insights from in silico, in vitro and experimental pharmacology in wistar rats DOI
Shankar Gharge, Shankar G. Alegaon, Shriram D. Ranade

et al.

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 153, P. 107966 - 107966

Published: Nov. 17, 2024

Language: Английский

Citations

7
Key molecular scaffolds in the development of clinically viable α-amylase inhibitors DOI
Rahul Pratap Singh, Jayant Sindhu,

Devender Singh

et al.

Future Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 17(3), P. 347 - 362

Published: Jan. 21, 2025

The escalating cases of type II diabetes combined with adverse side effects current antidiabetic drugs spurred the advancement innovative approaches for management postprandial glucose levels. α-Amylase is an endoamylase responsible breakdown internal α-1,4-glycosidic linkages in dietary starch, producing oligosaccharides. Subsequently, α-glucosidase degraded these oligosaccharides to monosaccharides, which are absorbed into bloodstream and become available body. inhibitors α-amylase reduced digestibility carbohydrates accompanied by delayed absorption, leading decreased blood levels after meals thus, inhibition enzyme seems be a crucial strategy improving overall glycemic control diabetic patients. present review article emphasizes therapeutic promise recently discovered potential inhibitors, highlighting their vitro, silico vivo profiles. Ultimately, we addressed contemporary challenges routes ahead search safe reliable clinical use, summarizing most recent research field.

Language: Английский

Citations

0
A highly active angiotensin I-converting enzyme inhibitory peptide KAKW designed based on the role of C-terminal residue, and its antihypertensive effects on spontaneously hypertensive rats DOI

Yangting Hu,

Dewei Xie,

Xujun Chen

et al.

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 117564 - 117564

Published: March 1, 2025

Language: Английский

Citations

0
Synthesis, in vitro and in vivo evaluation, and computational modeling analysis of thioxothiazolidine derivatives as highly potent and selective α-amylase inhibitors DOI

Anil Ravi,

Sumera Zaib,

Shabab Zahra

et al.

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 117584 - 117584

Published: April 1, 2025

Language: Английский

Citations

0
Design, synthesis, and biological evaluation of A2A adenosine receptor antagonists containing pyrrolo[2,3-d]pyrimidin-2-amine skeleton DOI
Zhi Li,

Xinzhen Fu,

Jiaqi Liu

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 108664 - 108664

Published: June 1, 2025

Language: Английский

Citations

0
Synthesis, C-N/N-N Bond Conformational Analysis and Evaluation of Naphtho[2,3-d][1,2,3]triazole-4,9-dione tethered N-acyl Hydrazones as α-Amylase Inhibitors: Insights from Molecular Modeling and ADMET Analysis DOI
Meena Devi, Jayant Sindhu, Rahul Singh

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1322, P. 140390 - 140390

Published: Oct. 16, 2024

Language: Английский

Citations

1
2‐Chloroquinolinyl‐thiazolidine‐2,4‐dione Hybrids as Potential α‐Amylase Inhibitors: Synthesis, Biological Evaluations, and In Silico Studies DOI

Sheetal B. Karmur,

Monil P. Dholariya, Anil S. Patel

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(39)

Published: Oct. 1, 2024

Abstract Recently, molecular hybridization strategy has paved a way to develop novel lead compounds for the α‐amylase targeted antidiabetic therapy. In this study, we disclosed series of new hybrids thiazolidine‐2,4‐diones with 2‐chloroquinoline‐3‐yl moiety as potential agents. The structures all synthesized ( 15a–n ) were confirmed by spectroscopic studies (FT‐IR, ESI‐MS, 1 H, 13 C NMR, and elemental analysis). When in vitro evaluation these agents was carried out dose‐dependent manner, it revealed that several 15f– h , 15j, 15n endowed significant activities exhibited more than 50% inhibition at dose 50 µg/mL. Particularly, hybrid found be potent acarbose 95% IC 5.00 ± 0.18 µM under given conditions. Further, demonstrated bearing 2‐chloroquinolinyl thiazolidin‐2,4‐dione scaffolds functionalized 3‐OMe 4‐OH groups not only able effectively bind receptor site best docking score (−9.644 kcal/mol) but also possessed drug‐likenesses properties no violations Lipinski rule. Overall, study discovered 2‐chloroquinolinyl‐thiazolidine‐2,4‐diones inhibitors compound promising its further development agent.

Language: Английский

Citations

0