A Collection of Novel Antitumor Agents That Regulate Lipid Metabolism in the Tumor Microenvironment DOI
Jiahao Zhang, Sha Xu,

Lingfeng Yue

et al.

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 27, 2024

Lipid metabolism disorder is the cause of one most significant metabolic changes in tumors. In process tumor occurrence and development, cells choose a continuous adaptation to accommodate changing environment maximum extent possible. variety tumors, uptake, production, storage lipids are generally upregulated. Tumor take advantage lipid access basic energy, biofilm components, signal molecules microenvironment required for proliferation, survival, invasion, metastasis. This Perspective briefly uncovers main processes key factors involved reprogramming, mainly related de novo synthesis fatty acids, oxidation cholesterol synthesis, regulatory factors. From medicinal chemistry perspective, agents against targets reviewed, expecting pave way promising antitumor drugs with prospects application through reprogramming.

Language: Английский

Synthesis and Bio-evaluation of Aminoferrocene-Based Anticancer Prodrugs as Potent Ferroptosis Inducers DOI

Qianer Zhang,

Xuejing Fan,

Huimei Qian

et al.

Inorganic Chemistry Frontiers, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Novel ROS-responsive N -alkylaminoferrocene (NAAF)-appended GPX4 inhibitors have been designed and prepared as potent ferroptosis-inducing prodrugs.

Language: Английский

Citations

0
An overview of GPX4-targeting TPDs for cancer therapy DOI
Xiaojuan Yang, Liqiang Wu,

Shaohong Xu

et al.

Bioorganic & Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 118, P. 118046 - 118046

Published: Dec. 15, 2024

Language: Английский

Citations

1
A Collection of Novel Antitumor Agents That Regulate Lipid Metabolism in the Tumor Microenvironment DOI
Jiahao Zhang, Sha Xu,

Lingfeng Yue

et al.

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 27, 2024

Lipid metabolism disorder is the cause of one most significant metabolic changes in tumors. In process tumor occurrence and development, cells choose a continuous adaptation to accommodate changing environment maximum extent possible. variety tumors, uptake, production, storage lipids are generally upregulated. Tumor take advantage lipid access basic energy, biofilm components, signal molecules microenvironment required for proliferation, survival, invasion, metastasis. This Perspective briefly uncovers main processes key factors involved reprogramming, mainly related de novo synthesis fatty acids, oxidation cholesterol synthesis, regulatory factors. From medicinal chemistry perspective, agents against targets reviewed, expecting pave way promising antitumor drugs with prospects application through reprogramming.

Language: Английский

Citations

0