Expression of PPAR-γ TF by newly synthesized thiazolidine-2,4-diones to manage glycemic control: Insights from in silico, in vitro and experimental pharmacology in wistar rats
Bioorganic Chemistry,
Journal Year:
2024,
Volume and Issue:
153, P. 107966 - 107966
Published: Nov. 17, 2024
Language: Английский
PPARγ modulator predictor (PGMP_v1): chemical space exploration and computational insights for enhanced type 2 diabetes mellitus management
Molecular Diversity,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 1, 2025
Language: Английский
Design, synthesis and molecular dynamics simulations of thiazole-based hydrazones targeting MDA-MB-231 breast cancer cells
Bioorganic Chemistry,
Journal Year:
2025,
Volume and Issue:
157, P. 108306 - 108306
Published: Feb. 23, 2025
Language: Английский
Novel quinoline–imidazole derivatives as inhibitors of Mycobacterium tuberculosis : an integrated approach combining molecular dynamics and in-vitro studies
Molecular Simulation,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 19
Published: March 14, 2025
The
rationale
for
designing
and
synthesising
quinoline–imidazole
hybrids
as
antitubercular
cytotoxic
agents
stems
from
the
strategic
combination
of
two
bioactive
structural
motifs
to
create
compounds
with
enhanced
efficacy,
dual
targeting,
potential
overcome
drug
resistance
challenges
in
tuberculosis
treatment.
Herein,
we
report
design
synthesis
hybrids.
FTIR,
Mass,
1H-NMR
13C-NMR
spectral
data
characterised
synthesised
compounds.
These
were
evaluated
their
activity
against
Mycobacterium
(MTB)
H37Rv
Hep
G2,
normal
mouse
fibroblast
L929
cell
lines.
evaluation
revealed
that
compound
6
g
exhibited
promising
activities
a
MIC
value
6.26
µg/ml,
while,
6d,
h
6i
showed
moderate
MTB
inhibition.
Additionally,
6d
demonstrated
cytotoxicity
HepG2
lines
an
IC50
46.74
±
1.209
μg/ml.
Further
selected
underwent
theoretical
investigation
via
molecular
docking,
stability
assessment
MD
trajectories
quantum
computations
justify
experimental
results.
obtained
predicted
silico
indicate
act
effective
inhibitors.
Language: Английский
Pioglitazone with SGLT2 inhibitors or GLP-1 receptor agonists in patients with type 2 diabetes and non-alcoholic fatty liver disease: could the combinations of an old friend with new players yield better outcomes?
Archives of Medical Science - Atherosclerotic Diseases,
Journal Year:
2025,
Volume and Issue:
10(1), P. 1 - 15
Published: March 14, 2025
More
than
25%
of
the
adult
population
worldwide
and
approximately
50–75%
patients
with
type
2
diabetes
are
diagnosed
non-alcoholic
fatty
liver
disease.
Insulin
resistance
is
one
most
crucial
factors
underlying
its
pathogenesis
a
significant
determinant
progression
to
steatohepatitis.
The
complex
pathophysiology
disease
emphasizes
need
for
combination
treatment
strategies
drug
classes
that
target
different
cellular
pathways,
since
no
single
agent
can
control
all
mechanisms
contributing
development
evolution.
Pioglitazone,
main
thiazolidinedione
in
clinical
practice,
only
true
insulin
sensitizing
antidiabetic
our
therapeutic
armamentarium
diabetes.
Current
international
practice
guidelines
recommend
PIO
as
promising
therapy
who
experience
NASH
GLP-1
receptor
agonists
SGLT2
inhibitors
have
shown
salutary
cardiometabolic
renal
effects
diabetes,
well
beneficial
activities
those
This
review
discusses
pathophysiological
background
use
these
three
categories
It
also
explores
thoroughly
combinations
pioglitazone
either
or
inhibitors,
their
future
role
this
setting.
Language: Английский
Structure-Based Insights into Fatty Acid Modulation of Lipid-Sensing Nuclear Receptors PPARδ/γ for Glycemic Regulation
Shankar Gharge,
No information about this author
Charushila V. Balikai,
No information about this author
Sachin Gudasi
No information about this author
et al.
Aspects of Molecular Medicine,
Journal Year:
2025,
Volume and Issue:
unknown, P. 100079 - 100079
Published: March 1, 2025
Language: Английский
Unleashing the potential of traditional Chinese medicine: a computational approach to discovering drug targets utilizing the CSLN and molecular dynamics
Qi Geng,
No information about this author
Pengcheng Zhao,
No information about this author
Zhiwen Cao
No information about this author
et al.
Molecular Diversity,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 3, 2025
Language: Английский
Comprehensive Review on Anti-Obesity Effects of Plant-Derived Compounds: Evidence from 3T3-L1 Adipocytes and High-Fat Diet Models
Aspects of Molecular Medicine,
Journal Year:
2025,
Volume and Issue:
unknown, P. 100089 - 100089
Published: May 1, 2025
Language: Английский
Novel rhodanine-thiazole hybrids as potential antidiabetic agents: A structure-based drug design approach
RSC Medicinal Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 21, 2024
New
rhodanine–thiazole
clubbed
compounds
(7a–7l)
were
synthesised
and
characterised
with
various
spectroscopy
methods.
Language: Английский