Pyrazoles: A Master Key to Tackle Multidrug‐Resistant Acinetobacter baumannii and Its Structure Activity Relationship Studies DOI

Saraswati Sharma,

S. Krishnam Raju,

Santosh Kumar Verma

et al.

Chemical Biology & Drug Design, Journal Year: 2025, Volume and Issue: 105(3)

Published: March 1, 2025

Infections caused by Gram-negative bacteria within the ESKAPE group pose significant treatment challenges. These feature effective efflux pumps and possess lipopolysaccharides in their outer membranes, as well a thin peptidoglycan layer measuring 5-10 nm thickness. Acinetobacter baumannii (A. baumannii), bacterium, is contributor to serious infections acquired hospitals communities, representing substantial risk human health. This bacterium has developed resistance nearly all existing antibiotics, past 50 years, no new antibacterial class been introduced for treating A. infections, highlighting an urgent necessity development of antibacterials. The unique structural framework adaptable features pyrazole ring attract researchers develop antibiotics. present study outlines advancements made over last decade pyrazole-containing derivatives that exhibit wide range activity against various bacterial strains. Specifically, we discuss effectiveness diverse multidrug-resistant strains explore aspects structure-activity relationship (SAR). compilation data could serve excellent platform designing developing pyrazole-based small molecules target growth baumannii.

Language: Английский

A systematic review on the anti-microbial activities and structure-activity relationship (SAR) of quinoxaline derivatives DOI

Sri Mounika Bellapukonda,

Rani Bandela,

Anuradha Singampalli

et al.

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 289, P. 117472 - 117472

Published: March 3, 2025

Language: Английский

Citations

1
Pyrazoles: A Master Key to Tackle Multidrug‐Resistant Acinetobacter baumannii and Its Structure Activity Relationship Studies DOI

Saraswati Sharma,

S. Krishnam Raju,

Santosh Kumar Verma

et al.

Chemical Biology & Drug Design, Journal Year: 2025, Volume and Issue: 105(3)

Published: March 1, 2025

Infections caused by Gram-negative bacteria within the ESKAPE group pose significant treatment challenges. These feature effective efflux pumps and possess lipopolysaccharides in their outer membranes, as well a thin peptidoglycan layer measuring 5-10 nm thickness. Acinetobacter baumannii (A. baumannii), bacterium, is contributor to serious infections acquired hospitals communities, representing substantial risk human health. This bacterium has developed resistance nearly all existing antibiotics, past 50 years, no new antibacterial class been introduced for treating A. infections, highlighting an urgent necessity development of antibacterials. The unique structural framework adaptable features pyrazole ring attract researchers develop antibiotics. present study outlines advancements made over last decade pyrazole-containing derivatives that exhibit wide range activity against various bacterial strains. Specifically, we discuss effectiveness diverse multidrug-resistant strains explore aspects structure-activity relationship (SAR). compilation data could serve excellent platform designing developing pyrazole-based small molecules target growth baumannii.

Language: Английский

Citations

0