Editorial: The emerging role of protein methylation/demethylation modification in disease and homeostasis

Frontiers in Molecular Biosciences, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 10, 2025

The significance of protein methylation and demethylation extends beyond basic cellular functions; they are critical in numerous biological processes, including development, differentiation, epigenetic regulation. For instance, histone is a well-studied modification that orchestrates chromatin structure gene expression, influencing identity function. Additionally, the non-histone proteins, such as transcription factors signaling molecules, further underscores complexity importance these modifications regulating activities. These not only fundamental to functions but also have profound implications more complex phenomena diseases. Understanding intricate mechanisms underlying crucial for unraveling their roles normal physiology disease pathology. As research this area progresses, it holds promise revealing potential therapeutic opportunities could transform our approach treating various proteins target, involvement chemoresistance, along with inhibitors 104 action. review addresses current challenges future directions PMT 105 combating cancer chemoresistance.

Language: Английский

Unraveling the Role of Ubiquitin-Conjugating Enzyme UBE2T in Tumorigenesis: A Comprehensive Review

Cells, Journal Year: 2024, Volume and Issue: 14(1), P. 15 - 15

Published: Dec. 26, 2024

Ubiquitin-conjugating enzyme E2 T (UBE2T) is a crucial in the ubiquitin-proteasome system (UPS), playing significant role ubiquitination of proteins and influencing wide range cellular processes, including proliferation, differentiation, apoptosis, invasion, metabolism. Its overexpression has been implicated various malignancies, such as lung adenocarcinoma, gastric cancer, pancreatic liver ovarian where it correlates strongly with disease progression. UBE2T facilitates tumorigenesis malignant behaviors by mediating essential functions DNA repair, cell cycle regulation, activation oncogenic signaling pathways. High levels expression are associated poor survival outcomes, highlighting its potential molecular biomarker for cancer prognosis. Increasing evidence suggests that acts an oncogene could serve promising therapeutic target treatment. This review aims to provide detailed overview UBE2T’s structure, functions, mechanisms involved progression well recent developments UBE2T-targeted inhibitors. Such insights may pave way novel strategies diagnosis treatment, enhancing our understanding biology supporting development innovative approaches.

Language: Английский