Unravelling drug resistance in leishmaniasis: genomic adaptations and emerging therapies DOI Creative Commons

Chandra Kanta Bhusal,

Shweta Sinha, Davinder Kaur

et al.

Frontiers in Molecular Biosciences, Journal Year: 2025, Volume and Issue: 12

Published: May 26, 2025

Leishmaniasis remains a significant global health challenge, with over billion people at risk of infection and limited effective treatment options due to escalating drug resistance. This review explores the underlying mechanisms resistance in Leishmania species, focusing on genomic plasticity as driving factor for survival adaptation. Key mechanisms, including genetic mutations, gene amplification, chromosomal rearrangements, efflux transporters, contribute parasite’s ability evade existing therapies. Advances proteomic studies have provided deeper insights into these pathways, enabling development novel therapeutic strategies. Additionally, this highlights current approaches, combination therapies potential new candidates, that address multidrug explore vulnerabilities . Understanding their clinical implications is essential developing targeted interventions improve outcomes combat leishmaniasis.

Language: Английский

Unravelling drug resistance in leishmaniasis: genomic adaptations and emerging therapies DOI Creative Commons

Chandra Kanta Bhusal,

Shweta Sinha, Davinder Kaur

et al.

Frontiers in Molecular Biosciences, Journal Year: 2025, Volume and Issue: 12

Published: May 26, 2025

Leishmaniasis remains a significant global health challenge, with over billion people at risk of infection and limited effective treatment options due to escalating drug resistance. This review explores the underlying mechanisms resistance in Leishmania species, focusing on genomic plasticity as driving factor for survival adaptation. Key mechanisms, including genetic mutations, gene amplification, chromosomal rearrangements, efflux transporters, contribute parasite’s ability evade existing therapies. Advances proteomic studies have provided deeper insights into these pathways, enabling development novel therapeutic strategies. Additionally, this highlights current approaches, combination therapies potential new candidates, that address multidrug explore vulnerabilities . Understanding their clinical implications is essential developing targeted interventions improve outcomes combat leishmaniasis.

Language: Английский

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