Novel insights into the N 6-methyladenosine modification on circRNA in cancer DOI Creative Commons
Qingling Xu, Yi Jia, Ying Liu

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: May 19, 2025

Circular RNAs (circRNAs) are a class of non-coding (ncRNAs) generated through the reverse splicing mRNA precursors (pre-mRNAs). They possess unique loop structure and exhibit remarkable stability. CircRNAs have emerged as promising biomarkers for cancer, with specific circRNAs playing crucial roles in cancer drug discovery, treatment, resistance mechanisms. N6 methyl adenosine (m6A) represents most prevalent RNA modification eukaryotes. In 2017, researchers identified that m6A modifications also occur circRNAs, displaying characteristics. m6A-modified undergo reversible regulation mediated by enzymes involved pathways. These modified interact m6A-binding proteins, thereby influencing processes such alternative splicing, translation degradation. Some enhance their metabolism or facilitate nuclear export to cytoplasm interacting regulation. The study has gained great attention circRNA research due association various diseases. This review summarizes functional mechanisms regulated implications occurrence therapy, primary focus on genesis, regulatory mechanisms, biology diverse types cancers. Additionally, we explore potential application clinical treatment.

Language: Английский

Novel insights into the N 6-methyladenosine modification on circRNA in cancer DOI Creative Commons
Qingling Xu, Yi Jia, Ying Liu

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: May 19, 2025

Circular RNAs (circRNAs) are a class of non-coding (ncRNAs) generated through the reverse splicing mRNA precursors (pre-mRNAs). They possess unique loop structure and exhibit remarkable stability. CircRNAs have emerged as promising biomarkers for cancer, with specific circRNAs playing crucial roles in cancer drug discovery, treatment, resistance mechanisms. N6 methyl adenosine (m6A) represents most prevalent RNA modification eukaryotes. In 2017, researchers identified that m6A modifications also occur circRNAs, displaying characteristics. m6A-modified undergo reversible regulation mediated by enzymes involved pathways. These modified interact m6A-binding proteins, thereby influencing processes such alternative splicing, translation degradation. Some enhance their metabolism or facilitate nuclear export to cytoplasm interacting regulation. The study has gained great attention circRNA research due association various diseases. This review summarizes functional mechanisms regulated implications occurrence therapy, primary focus on genesis, regulatory mechanisms, biology diverse types cancers. Additionally, we explore potential application clinical treatment.

Language: Английский

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