Recent Advances in the Use of Cubosomes as Drug Carriers with Special Emphasis on Topical Applications

Journal of Lipids, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Topical drug delivery employing nanocarriers has shown prominent results in treating topical ailments, especially those confined to the skin and eyes. Conventional formulations persist with disease‐related challenges during treatment. Various nanotechnology‐driven approaches have been adopted mitigate issues associated conventional formulations. Among these, cubosomes potential applications owing their liquid crystalline structure, which aids bioadhesion, retention, sustained release, loading hydrophilic hydrophobic moieties. The phase transition behavior of glyceryl monooleate, concentration stabilizers, critical packing parameters are crucial that affect formation cubosomes. Microfluidics‐based constitute a recent advance technologies for generating stable This review covers (psoriasis, cancer, cutaneous candidiasis, acne, alopecia) eye (fungal keratitis, glaucoma, conjunctivitis, uveitis) diseases. article summarizes manufacturing biological (skin ocular barriers) must be considered encountered successful clinical outcomes. patented products examples technological advancements within cosmeceuticals support various pharmaceutical field.

Language: Английский

---

Current State of Lipid Nanoparticles (SLN and NLC) for Skin Applications

Current Pharmaceutical Design, Journal Year: 2023, Volume and Issue: 29(21), P. 1632 - 1644

Published: June 1, 2023

Abstract: The increasing knowledge on skin physiology, formulation science and nanotechnology has led to continuous improvements in cosmetics, introduction of dermocosmetics been particularly for the management disorders such as acne, eczema, psoriasis, etc. Nowadays, research focused development products which can efficiently administer active compounds target layers while minimizing side effects. use multifunctional lipid nanoparticles cosmetic dermocosmetic purposes is promising not only because biocompatible ingredients are used their composition, but also ability show enhanced penetration. Although liposomes a hallmark nanoparticles, novel systems capable encapsulating with tunable release profiles, that good stability, easy manufacture handle remains necessity. Solid (SLN) were introduced alternative formulations emulsions, polymeric whereas nanostructured carriers (NLC) developed later second-generation nanoparticles. However, both SLN NLC many inherited advantageous properties be dermal applications including provide occlusion photoprotective effect hydration, various based already market. This review provides an overview current state-of-art purposes, discuss structures preparation techniques. Their topical delivery different highlighted along examples commercialized products.

Language: Английский

---

Comprehensive review of the skin use of bakuchiol: physicochemical properties, sources, bioactivities, nanotechnology delivery systems, regulatory and toxicological concerns

Phytochemistry Reviews, Journal Year: 2024, Volume and Issue: 23(5), P. 1377 - 1413

Published: March 1, 2024

Abstract Bakuchiol is a meroterpene that has recently aroused great interest in the cosmetic and pharmaceutical industries. Its main source seeds of Psoralea corylifolia, medicinal plant native to Asia, despite having wide geographical distribution. However, this herb faces endangerment due low seed germination rates high seedling mortality. In context, review article highlights studies have focused on describing regeneration from root fragments. Subsequently, given its morphological similarity other species, technique can be used verify authenticity prevent counterfeiting also mentioned explored. Additionally, “green” extraction method for obtaining bakuchiol presented, possibility through chemical synthesis routes Furthermore, we provide an exhaustive description bakuchiol's range biological activities, with particular relevance skin. The skin bioactivities include antifungal, antibacterial, antioxidant, anti-inflammatory, antiaging, depigmenting, anticancer. physicochemical properties require benefit development innovative delivery systems allow encapsulation. These micro- nano-sized therapeutic applications, which are carefully described article. Finally, regulatory issues, metabolic considerations, toxicological concerns related use dermopharmaceutical formulations will addressed, relating not only user but environment. Graphical abstract

Language: Английский

---

Berberine HCl and diacerein loaded dual delivery transferosomes: Formulation and optimization using Box-Behnken design

ADMET & DMPK, Journal Year: 2024, Volume and Issue: unknown

Published: April 29, 2024

Introduction: Berberine is a poorly water-soluble alkaloid compound showing significant anti-inflammatory characteristics. It reduces the levels of pro-inflammatory and inflammatory cytokines, including tumour necrosis factor (TNF-????, IFN-????) interleukin (IL-23, IL-12, IL-23). Diacerein significantly splenomegaly associated with psoriasis. downregulates production TNF-α IL-12. Method: This study reported development transferosomes containing berberine HCl diacerein using film hydration method followed by optimization Box-Behnken design. Sodium deoxycholate was used as an edge activator. The impact independent variables (amount phosphatidylcholine, amount activator, sonication cycles) on dependent (particle size entrapment efficiency) examined. optimized formulation characterized for polydispersity index, vesicle size, efficiency, ζ potential, spectral analysis like Fourier transform infrared, thermal analysis, X-ray diffraction, deformability, transmission electron microscopy, antioxidant assay, in-vitro release, ex-vivo skin permeation studies. Results: had particle 110.90±2.8 nm high efficiency (89.50±1.5 91.23±1.8 diacerein). Deformability, activity were 2.44, 0.296, -13.3, 38.36 %, respectively. Optimized exhibited 82.093±0.81 % 85.02±3.81 release after 24 h dissolution study. transdermal flux 0.0224 µg cm-2 h-1 (2.24 cm coefficient) 0.0462 (4.62 coefficient), respectively, diacerein. Raman treated pig confirmed that can permeate skin. No change in condition or irritation observed BALB/c mice. Formulation stored at 4 25±2 °C / 60±5 relative humidity stable 3 months. Conclusions: Thus, results demonstrated successful efficient topical delivery effective management

Language: Английский

---

Microneedle system for tissue engineering and regenerative medicines: a smart and efficient therapeutic approach

Biofabrication, Journal Year: 2024, Volume and Issue: 16(4), P. 042005 - 042005

Published: Aug. 9, 2024

The global demand for an enhanced quality of life and extended lifespan has driven significant advancements in tissue engineering regenerative medicine. These fields utilize a range interdisciplinary theories techniques to repair structurally impaired or damaged tissues organs, as well restore their normal functions. Nevertheless, the clinical efficacy medications, materials, potent cells used at laboratory level is always constrained by technological limitations. A novel platform known adaptable microneedles been developed address abovementioned issues. offer solution localized distribution various cargos while minimizing invasiveness. Microneedles provide favorable patient compliance settings due effective administration ability painless convenient process. In this review article, we summarized most recent development microneedles, started classifying microneedle systems, advantages, fundamental properties. Subsequently, it provides comprehensive overview different types material fabricate properties ideal applications medicine, primarily focusing on preserving restoring organs. limitations perspectives have discussed concluding future therapeutic medicines.

Language: Английский

---

Novel strategies in topical delivery for psoriasis treatment: nanocarriers and energy-driven approaches

Expert Opinion on Drug Delivery, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Psoriasis is characterized by abnormal differentiation and hyperproliferation of epidermal keratinocytes. This condition presents significant challenges for effective drug delivery. In addition to overcoming the thickness skin, topical treatments must navigate complex hydrophobic hydrophilic properties skin barrier. Recent advancements in nanocarrier technologies, including energy-driven methods microneedles that penetrate stratum corneum, present promising strategies enhancing permeation through tailored physicochemical properties. A literature search was performed using databases Google Scholar, PubMed, ScienceDirect. review highlights recent studies on novel delivery psoriasis treatment, addressing current therapeutic options their limitations. We provide a comprehensive overview chemical nanoformulations explore physical improve rates. Furthermore, we discuss advantages various formulations can carry different types payloads, offering patients diverse symptom management. The covers conventional treatments, emphasizing nanoparticle design macromolecular drugs. includes Ribonucleic acid (RNA)-based therapies protect drugs from rapid clearance body. argue intelligent approaches enhance efficacy across applications while allowing precision treatment strategies, ultimately improving patient outcomes.

Language: Английский

---

Liposomes-in-Gel as the Docetaxel Delivery for the Effective Treatment of Psoriasis by Inhibiting the Proliferation of Blood Vessels

Gels, Journal Year: 2025, Volume and Issue: 11(4), P. 228 - 228

Published: March 22, 2025

Psoriasis is a chronic skin disease caused by the interaction of multiple factors that leads to abnormal growth stratum corneum cells and has been called an immortal cancer. Docetaxel trialed for treatment psoriasis due its superior ability induce apoptosis, but insolubility low bioavailability have hampered development. Here, docetaxel (DTX)-loaded liposomes-in-gel (DTX-LP-G) as transdermal delivery was investigated via modulating IL6-HIF-1α-VEGF axis. The results demonstrated DTX-LP-G cumulatively released much higher amount drug into than from DTX-loaded liposomes (DTX-LPs) gel (DTX-G). also most efficient in scavenging hydrogen peroxide free radicals vitro. In mouse model psoriasis, acted preliminary therapeutic agent terms apparent evaluation, splenomegaly, suppression MDA content tissue, down-regulated expression IL6, HIF-1α, VEGF control proliferation vessels, except less pronounced effect on corneum. addition, enrichment analysis can speculate DTX treated resisting production keratin-forming cells.

Language: Английский

---

Enhanced drug delivery with nanocarriers: a comprehensive review of recent advances in breast cancer detection and treatment

Discover Nano, Journal Year: 2024, Volume and Issue: 19(1)

Published: Sept. 7, 2024

Breast cancer (BC) remains a leading cause of morbidity and mortality among women worldwide, with triple-negative breast (TNBC) posing significant treatment challenges due to its aggressive phenotype resistance conventional therapies. Recent advancements in nanocarrier technology offer promising solutions for enhancing drug delivery, improving bioavailability, increasing accumulation at tumor sites through targeted approaches. This review delves into the latest innovations BC detection treatment, highlighting role nanocarriers like polymeric micelles, liposomes, magnetic nanoparticles overcoming limitations traditional Additionally, manuscript discusses integration cutting-edge diagnostic tools, such as multiplex PCR-Nested Next-Generation Sequencing (mPCR-NGS) blood-based biomarkers, which are revolutionizing early molecular profiling BC. The convergence these technologies not only enhances therapeutic outcomes but also paves way personalized medicine management. comprehensive underscores potential transforming emphasizes critical importance patient prognosis.

Language: Английский

---

Emerging Therapeutic Agents and Nanotechnology-Driven Innovations in Psoriasis Management

Frontiers in Bioscience-Landmark, Journal Year: 2025, Volume and Issue: 30(3)

Published: March 19, 2025

Psoriasis has been a rising concern for over decade, imposing significant challenges to individuals and society. Traditional topical therapy is non-targeted acts systemically, with associated side effects. This increases the global burden both socially economically. review covers evolution of drug molecules nanotechnology-based approaches treatment psoriasis, chronic inflammatory skin disorder no known etiology. Nanotechnology-based offer promising solutions by reducing effects, providing targeted delivery, protecting from degradation, enhancing retention, controlled release. Researchers have investigated incorporation various conventional non-conventional therapeutic agents into nanocarriers psoriasis treatment. The current understanding disease its using combined novel formulation strategies will reduce duration improve quality life in psoriatic conditions.

Language: Английский

---

Synergistic convergence of selenium and nanotechnology in dermatological therapeutics: Mechanistic insights and clinical prospects

Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 111298 - 111298

Published: May 1, 2025

Language: Английский

---